Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Raman, N, Nordin, F, Imran, SAM, Md Sabri, BA, Susanti, D, Noordin, KBAA et al.. Knowledge and attitude of Malaysian university students towards regenerative medicine therapy and their clinical implications: a cross-sectional study. Front Genet. 2026;17 :1804348. doi: 10.3389/fgene.2026.1804348. PubMed PMID:42578174 PubMed Central PMC13456652.
  2. Han, K, Cho, YS, Takahashi, M, Zhou, X, Dobson, HE, Hutchings, K et al.. Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy. Nat Nanotechnol. 2026; :. doi: 10.1038/s41565-026-02235-9. PubMed PMID:42575976 .
  3. Li, M, Wen, Y, Ding, Y, Tian, W, Guo, S. An immunomodulatory hydrogel encapsulating dental follicle stem cell-derived small extracellular vesicles promotes neutrophil clearance and periodontal bone regeneration. Biomaterials. 2026;337 :124522. doi: 10.1016/j.biomaterials.2026.124522. PubMed PMID:42574960 .
  4. Ito, Y, Dong, S, Kato, H, Zhou, Z, Wang, L, Hirofuji, Y et al.. Gain-of-function mutation of type 2 ryanodine receptor attenuates dopaminergic neuron development associated with Ca2+ overload-triggered oxidative damage in mitochondria. Biochem Biophys Res Commun. 2026;833 :154416. doi: 10.1016/j.bbrc.2026.154416. PubMed PMID:42574940 .
  5. Chen, H, Wang, R, Wang, S, Zheng, X, Ma, R, Wu, J et al.. Enhanced Biological Performance of Fractal Geometry Design on Titanium for Dental Implant Application: An In Vitro Study. ACS Biomater Sci Eng. 2026;12 (8):4236-4248. doi: 10.1021/acsbiomaterials.6c00628. PubMed PMID:42573490 .
  6. Usami, FM, Arata, M, Kato, K, Shi, D, Oka, S, Yang, Y et al.. Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds. Proc Natl Acad Sci U S A. 2026;123 (32):e2605383123. doi: 10.1073/pnas.2605383123. PubMed PMID:42550897 .
  7. Devi, JD, Bottu, K, Sekar, R, Logeswari, J. Identification and characterization of stem cells in three different oral structures by immunohistochemistry. An in vitro study. J Oral Maxillofac Pathol. 2026;30 (2):270-279. doi: 10.4103/jomfp.jomfp_116_26. PubMed PMID:42569711 PubMed Central PMC13450922.
  8. Basu Roy, R, Azariah, EDS, Deepak, C, Punnoose, AM, Paramesh, V. A comparative study of clonogenic potential of primary cells from dental pulp and gingiva in an individual. J Oral Maxillofac Pathol. 2026;30 (2):280-286. doi: 10.4103/jomfp.jomfp_377_25. PubMed PMID:42569699 PubMed Central PMC13450929.
  9. Liu, H, Chen, C, Li, M, Häkkinen, L, Hieawy, A, Wei, X et al.. An innate defense regulator peptide modulates the inflamed pulp microenvironment and promotes pulp repair. Bioact Mater. 2026;66 :1133-1149. doi: 10.1016/j.bioactmat.2026.06.050. PubMed PMID:42569337 PubMed Central PMC13449987.
  10. Zhou, Y, Luo, X, Xiao, L. Melatonin attenuates peri-implantitis by promoting HAT1-mediated succinylation of p65 to inhibit p65 nuclear translocation. Mol Immunol. 2026;198 :40-49. doi: 10.1016/j.molimm.2026.08.004. PubMed PMID:42567060 .
  11. Zhao, ST, Zhang, YW, Pan, YH, Yan, XZ. 3D-BMSC Spheroids Enhance Bone Repair Associated with H-Type Vessels and Immunomodulation. Tissue Eng Part A. 2026; :19373341261473151. doi: 10.1177/19373341261473151. PubMed PMID:42563599 .
  12. Pirimoğlu, B, Keskin, C, Yüce, M, Keskin, M, Nuhoğlu, Z, Albayrak, E et al.. Comparison of periapical cyst- and dental pulp-derived mesenchymal stem cells: an in vitro study on proliferation, differentiation, migration, and odontogenic potential. In Vitro Cell Dev Biol Anim. 2026; :. doi: 10.1007/s11626-026-01234-3. PubMed PMID:42562997 .
  13. McKay, LK, Vann, CG, Bain, JR, Kuang, S, Newgard, CB, White, JP et al.. Metabolomics-guided isolation of myogenic progenitor cells for improved transplantation. Am J Physiol Cell Physiol. 2026; :. doi: 10.1152/ajpcell.00337.2026. PubMed PMID:42562799 .
  14. Gu, T, Song, W, Pan, Y, Yi, J, Xu, T, Xu, K et al.. OTUB1 Promotes Odontogenesis in Dental Pulp Stem Cells by Mediating TPM1 Deubiquitination and Activating Autophagy. Int Dent J. 2026;76 (5):109814. doi: 10.1016/j.identj.2026.109814. PubMed PMID:42561883 .
  15. Bahrami, R, Pourhajibagher, M, Bahador, A. Photobiomodulation Therapy and Wnt/β-Catenin Signaling in Periodontal Ligament Stem Cells: is there a Mechanistic Link Accelerating Orthodontic Tooth Movement?. Stem Cell Rev Rep. 2026; :. doi: 10.1007/s12015-026-11208-3. PubMed PMID:42560434 .
  16. Bose, S, Robertson, SF, Kushram, P, Dernell, W, Goodman, SB, Bandyopadhyay, A et al.. Design and Manufacturing of Multifunctional Hydroxyapatite-Coated Ti6Al4V Implants With Cissus quadrangularis. J Biomed Mater Res A. 2026;114 (8):e70135. doi: 10.1002/jbm.a.70135. PubMed PMID:42557725 .
  17. Wang, M, Wang, L, Wang, J, Gao, S, Li, G, Tang, C et al.. Ckb-Cryab-Drp1 axis enhances BMSC osteogenic differentiation and mouse alveolar bone healing through mitochondrial fission modulation. Stem Cells Transl Med. 2026;15 (8):. doi: 10.1093/stcltm/szag056. PubMed PMID:42556330 PubMed Central PMC13441178.
  18. Rong, Q, Guo, Y, Wang, T, Tan, X. Synergistic regulation of hDPSC-iPSCs by tetrahedral DNA nanostructures for dentin-pulp complex regeneration. Stem Cells Transl Med. 2026;15 (8):. doi: 10.1093/stcltm/szag052. PubMed PMID:42556323 PubMed Central PMC13441177.
  19. Ke, LAT, Nguyen, AN, Pham, NM, Dang, LP, Tran, HYT, Vo, QD et al.. Therapeutic Applications of Induced Pluripotent Stem Cell Technology in Kidney Disease: A Systematic Review and Meta-Analysis. Kidney Dis (Basel). 2026;12 (1):693-710. doi: 10.1159/000553106. PubMed PMID:42553915 PubMed Central PMC13436944.
  20. Mokhtari, H, Fakhri, E, Sadrhaghighi, A, Eslami, H, Amirsaadat, S, Behrouzpour, E et al.. Laser-induced modulation of root dentin surface for growth factor release and enhanced stem cell response. Lasers Med Sci. 2026;41 (1):. doi: 10.1007/s10103-026-04971-9. PubMed PMID:42550280 PubMed Central PMC13437569.
  21. Ravichandran, S, Kumaravadivel, K, Vishwanath, S, Raj, BJ, Mathew, S, Thangaraj, DN et al.. Direct effect of nitrofurantoin on dental pulp stem cell viability and odontoblastic differentiation potential. J Conserv Dent Endod. 2026;29 (7):717-721. doi: 10.4103/JCDE.JCDE_192_26. PubMed PMID:42549323 PubMed Central PMC13432219.
  22. Stangl, FK, Huth, KC, Högg, C. Cytotoxicity of released monomers, additives, and ions from bioactive dental liners in human dental pulp stem cells. Dent Mater. 2026; :. doi: 10.1016/j.dental.2026.07.021. PubMed PMID:42547345 .
  23. Liu, H, Zhou, L, Ye, J, Song, D, Cao, R, Luo, R et al.. High-throughput design of 3D hybrid stem cell spheroids loaded with zinc-doped urchin-like hydroxyapatite and their osteopromotive bionics. Biofabrication. 2026; :. doi: 10.1088/1758-5090/ae9403. PubMed PMID:42546772 .
  24. Rahimpour, S, Azizi, A, Hodjat, M, Vahedi, M. Effects of 660 and 940nm Low-Level Laser Irradiation on Viability and Proliferation of Stem Cells from Human Exfoliated Deciduous Teeth. Front Dent. 2026;23 :7. doi: 10.18502/fid.v23i7.21236. PubMed PMID:42542800 PubMed Central PMC13428510.
  25. Mottaghi, M, Attaran Khorasani, A, Samadian, S, Farshbaf, A, Mohareri, M, Ahrari, F et al.. Recent Bioengineering Strategies and Clinical Applications in Dentistry of Oral and Maxillofacial Organoids. Int Dent J. 2026;76 (5):109777. doi: 10.1016/j.identj.2026.109777. PubMed PMID:42541860 PubMed Central PMC13453469.
  26. Selenou, C, Brioude, F, Sudre, L, Pham, A, Netchine, I, Sobrier, ML et al.. Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models. Epigenetics. 2026;21 (1):2690360. doi: 10.1080/15592294.2026.2690360. PubMed PMID:42531143 PubMed Central PMC13432853.
  27. Tosa, I, Kitagawa, W, Kheyfets, B, Yoon, H, Salinas, MA, Stipano, E et al.. A single-cell transcriptomic atlas identifies hierarchical skeletal progenitors and zonal patterning in mouse mandibular cartilage. Cell Rep. 2026;45 (8):117743. doi: 10.1016/j.celrep.2026.117743. PubMed PMID:42531128 .
  28. Shichkin, VP, Shinzawa, M, Filipp, D, Antica, M, Delfino, DV. Editorial: Thymus research and development: a new look at the past, current knowledge, and future perspectives. Front Immunol. 2026;17 :1919476. doi: 10.3389/fimmu.2026.1919476. PubMed PMID:42529630 PubMed Central PMC13417988.
  29. Miwa, Y, Tsuji, N, Hoshi, K, Hikita, A. Macrophages Primed with Hyaluronic Acid Promote Bone Regeneration in Mouse Peri-Implantitis Model. Tissue Eng Part A. 2026; :19373341261473146. doi: 10.1177/19373341261473146. PubMed PMID:42528327 .
  30. Leite, AA, DA Silva, LC, Borgato, GB, Kowalski, LP, Dos Santos-Silva, AR, Lopes, MA et al.. Cephaeline Disrupts Cancer Stem Cell Pathways to Enhance Chemotherapy Response in Oral Squamous Cell Carcinoma Cells. Anticancer Res. 2026;46 (8):4239-4250. doi: 10.21873/anticanres.18283. PubMed PMID:42527078 .
  31. Yushkov, AV, Kuvshinova, EA, Bulygina, IN, Zakharova, VA, Saryglar, RY, Vakhrushev, IV et al.. Comparative study of the bioactive PLGA/CaP composites: the influence of 3D structure on inflammatory and osteoinductive properties. Biomed Mater. 2026; :. doi: 10.1088/1748-605X/ae9233. PubMed PMID:42526496 .
  32. Phlinyos, T, Phothichailert, S, Osathanon, T, Sukarawan, W. Extracellular calcium regulates the reciprocal osteogenic and adipogenic commitment of Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs). Arch Oral Biol. 2026;191 :106697. doi: 10.1016/j.archoralbio.2026.106697. PubMed PMID:42526140 .
  33. Ostapets, SV, Kosareva, OS, Drovosekov, MN, Nikitenko, EV, Surovtseva, MA, Kim, II et al.. Bone Defect Regeneration Using Mesenchymal Stem Cells from Bichat's Fat Pad. Sovrem Tekhnologii Med. 2026;18 (3):39-45. doi: 10.17691/stm2026.18.3.04. PubMed PMID:42524326 PubMed Central PMC13411062.
  34. Sirous, S, Chalmers, JC, Li, PY, Subhani, Y, Hernandez-Kapila, YL. Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly. Periodontol 2000. 2026; :. doi: 10.1111/prd.70062. PubMed PMID:42522905 .
  35. Sanaa, D, Elbattawy, W, Hassan, A, Magdeldin, S, Mokhtar, M, Abdelmoneim, TK et al.. Vitamins A- and C-augmented platelet-rich fibrin in periodontal intraosseous defects: A randomized clinical trial. J Periodontol. 2026; :. doi: 10.1002/jper.70173. PubMed PMID:42522415 .
  36. Duan, S, Su, Q, Yang, H, Hu, X, Zhang, A, Hu, T et al.. Histone acetylation promotes FKBP5 to increase reparative dentin formation in pulp repair. Stem Cells Transl Med. 2026;15 (8):. doi: 10.1093/stcltm/szag047. PubMed PMID:42522268 PubMed Central PMC13415464.
  37. Abbireddy, S, Joseph, J, Bagga, B, Shukla, S. Mesenchymal stem cell-derived conditioned medium demonstrates antifungal activity against ocular isolates of Candida albicans and Aspergillus flavus: a proof-of-concept study. Exp Eye Res. 2026;271 :111185. doi: 10.1016/j.exer.2026.111185. PubMed PMID:42521071 .
  38. Montoya, AG, Breulmann, LR, Tağman, RG, Kuckelkorn, C, Fischer, H. Acoustic droplet ejection enables the transfer of induced pluripotent stem cells in ultra-high concentrations while preserving their pluripotency. Biomed Mater. 2026;21 (4):. doi: 10.1088/1748-605X/ae91c1. PubMed PMID:42520840 .
  39. Zhuang, Z, Wang, P, Liu, Y, Song, L, Zhang, X, Ouyang, H et al.. Rational design of immunological programs for functional regenerative niches. Mater Today Bio. 2026;39 :103451. doi: 10.1016/j.mtbio.2026.103451. PubMed PMID:42518696 PubMed Central PMC13382434.
  40. Liu, X, Li, X, Yue, Y, Zheng, Y, Huang, W, Niu, J et al.. Selection of a novel MSC-targeted aptamer Pt-1 and its functionalized hydrogel for tissue regeneration. Mater Today Bio. 2026;39 :103410. doi: 10.1016/j.mtbio.2026.103410. PubMed PMID:42518693 PubMed Central PMC13382431.
  41. Mussin, NM, Tamadon, A, Mahdipour, M, Zhilisbayeva, KR, Kurmanalina, MA, Baspakova, A et al.. Stem cell and extracellular vesicle therapies for wound healing: An umbrella review of predominantly diabetic and preclinical evidence. Cell Transplant. 2026;35 :9636897261452345. doi: 10.1177/09636897261452345. PubMed PMID:42517600 PubMed Central PMC13420067.
  42. Vieira da Silveira, AB, Silva Oliveira, BL, Passucci Ambrósio, EC, Bergamo, MTOP, Pessoa, AS, Godoy Iano, F et al.. Effects of Bioactive Cements on the Cytotoxicity, Migration, Alkaline Phosphatase Activity, and Mineralization of SHED. Curr Stem Cell Res Ther. 2026; :. doi: 10.2174/011574888X473368260716202447. PubMed PMID:42517393 .
  43. Mekhemar, M, Hassanein, FEA, Abou-Bakr, A. Beyond receptor activation: biased toll-like receptor signaling in periodontal inflammation and regeneration. Front Immunol. 2026;17 :1852272. doi: 10.3389/fimmu.2026.1852272. PubMed PMID:42516396 PubMed Central PMC13402438.
  44. Altamimi, A, Ba-Armah, I, Alqarni, H, Almutairi, N, Altamimi, Y, Alenizy, M et al.. Novel Metformin-Containing Antibacterial Composite for Root Caries Restorations. Materials (Basel). 2026;19 (14):. doi: 10.3390/ma19142963. PubMed PMID:42513701 PubMed Central PMC13412206.
  45. Alqarni, A, Hosmani, J, Alqahtani, AMA, Assiri, HA, Meer, RM, Patil, S et al.. An Integrative Bioinformatics Framework Prioritises a Gingival Mesenchymal Stem Cell Paracrine Apoptosis-ROS Axis in HPV-Negative Oral Squamous Cell Carcinoma: Preliminary Experimental Support and Repurposable-Drug Hypotheses. Int J Mol Sci. 2026;27 (14):. doi: 10.3390/ijms27146480. PubMed PMID:42511823 PubMed Central PMC13411614.
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  48. Nedorubova, IA, Basina, VP, Meglei, AY, Sapelnikova, MG, Kulakov, AA, Goldshtein, DV et al.. Angiogenic and Regenerative Potential of Plasma-Based and Plasma-Free Platelet Concentrates Obtained via Different Fractionation and Activation Methods. Bioengineering (Basel). 2026;13 (7):. doi: 10.3390/bioengineering13070821. PubMed PMID:42510486 PubMed Central PMC13404599.
  49. Huang, D, Guo, H, Guan, W, Zheng, F, Liu, C, Shi, C et al.. The Interaction Between the Central Nervous System and Dental Tissues: Hypothetical Dental Interoception Inferred From Skeletal Interoception. J Oral Rehabil. 2026; :. doi: 10.1111/joor.70279. PubMed PMID:42508973 .
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  51. Zhang, J, Kawamoto, C, Yago, R, Sano, H, Minowa, F, Islam, A et al.. A Multimodal Assessment of a New Self-Adhering Flowable Composite: Dental Pulp Stem Cell Viability and Bond Strength. J Funct Biomater. 2026;17 (7):. doi: 10.3390/jfb17070314. PubMed PMID:42506540 PubMed Central PMC13413257.
  52. Yang, D, Luo, Y, Huang, F, Hu, L, Deng, X, Zhang, S et al.. Hyperpolarization by Optogenetic Activation of NpHR Channels Promotes Osteogenic Differentiation of Human Dental Follicle Stem Cells. Membranes (Basel). 2026;16 (7):. doi: 10.3390/membranes16070230. PubMed PMID:42506195 PubMed Central PMC13414404.
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