Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Isolation methods of exosomes derived from dental stem cells. Int J Oral Sci. 2025;17 (1):50. doi: 10.1038/s41368-025-00370-y. PubMed PMID:40523888 .
  2. Yue, Z, Gong, W, Chu, H, Li, Y. PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis. Tissue Eng Regen Med. 2025; :. doi: 10.1007/s13770-025-00723-y. PubMed PMID:40522441 .
  3. Shekatkar, M, Kheur, S, Deshpande, S, Sakhare, S, Sanap, A, Kharat, A et al.. Enhancing angiogenesis through secretomes: Insights from scratch wound assay. J Oral Biol Craniofac Res. 2025;15 (4):789-798. doi: 10.1016/j.jobcr.2025.05.008. PubMed PMID:40520763 PubMed Central PMC12167018.
  4. Anuar Shariff, K, Patera Nugraha, A, Hafedh Mohammed Mohammed, A, Bagus Narmada, I, Gusti Aju Wahju Ardani, I, Faradilla Ramadhani, N et al.. Osteoinductivity performance dicalcium phosphate dihydrate-coated porous β-tricalcium phosphate granules in adipose-derived mesenchymal stem cells. Dent Mater J. 2025; :. doi: 10.4012/dmj.2024-310. PubMed PMID:40518314 .
  5. Zhuang, Z, Han, C, Cai, M, Li, M, Lin, S, Chen, L et al.. The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.026. PubMed PMID:40518112 .
  6. Hodjat, M, Khan, F, Mohammadpour, H, Asadi, N. Restoring impaired osteogenic differentiation of diabetic rat stromal cells using epigenetic inhibitors. Adv Med Sci. 2025; :. doi: 10.1016/j.advms.2025.06.001. PubMed PMID:40517812 .
  7. Wang, S, Zhuang, D, Xu, Q, Hou, D, Feng, T, Guo, J et al.. Biomaterial-enhanced delivery of stem cell-derived exosomes for skin inflammatory diseases: Mechanisms and therapeutic advances. Int J Biol Macromol. 2025; :145213. doi: 10.1016/j.ijbiomac.2025.145213. PubMed PMID:40516725 .
  8. Dong, Q, Zhang, H, Zhang, Q, Fei, X, Ruan, J, He, L et al.. Dimethyloxalylglycine regulates osteogenesis of dental pulp stem cells through PI3K/AKT signaling pathways. Tissue Cell. 2025;96 :103012. doi: 10.1016/j.tice.2025.103012. PubMed PMID:40516134 .
  9. Huang, S, Wu, Y, Zhao, H, Song, K, Liu, Y, Mao, J et al.. Advancements in bone organoids: perspectives on construction methodologies and application strategies. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.011. PubMed PMID:40513657 .
  10. Peng, H, Tan, J, Li, X. Loading curcumin on titanium nanotubes to improve surface biological activity. Biomed Mater. 2025; :. doi: 10.1088/1748-605X/ade488. PubMed PMID:40513615 .
  11. Aratikatla, A, Arcot, S, Gupta, M, Gupta, A. Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review. Indian J Orthop. 2025;59 (6):710-719. doi: 10.1007/s43465-024-01275-4. PubMed PMID:40511361 PubMed Central PMC12151939.
  12. Fujii, Y, Yoshida, T, Sato, A, Ikehata, M, Hatori, A, Chikazu, D et al.. Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling. Regen Ther. 2025;30 :100-106. doi: 10.1016/j.reth.2025.05.006. PubMed PMID:40511256 PubMed Central PMC12159295.
  13. Mieszkowska, A, Martocq, L, Koptyug, A, Surmeneva, MA, Surmenev, RA, Naderi, J et al.. Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111514. PubMed PMID:40508757 PubMed Central PMC12157878.
  14. Farjaminejad, R, Farjaminejad, S, Garcia-Godoy, F. Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111475. PubMed PMID:40508718 PubMed Central PMC12157830.
  15. Lai, SY, Lin, SI, Chang, CW, Shen, YR, Mine, Y, Lin, ZC et al.. Comparative Evaluation of Dental Clinical Surface Treatments for Polyetheretherketone with Airborne-Particle Abrasion, Hydrofluoric Acid Etching, and Handheld Nonthermal Plasma Activation on Long-Term Bond Performance. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111448. PubMed PMID:40508691 PubMed Central PMC12157909.
  16. Mosca Balma, A, Pedraza, R, Orrico, C, Meinardi, S, Genova, T, Gautier di Confiengo, G et al.. Poly(ε-Caprolactone)/Sodium Bicarbonate/β-Tricalcium Phosphate Composites: Surface Characterization and Early Biological Response. Materials (Basel). 2025;18 (11):. doi: 10.3390/ma18112600. PubMed PMID:40508598 PubMed Central PMC12155874.
  17. Patel, T, Mešić, J, Meretzki, S, Bronshtein, T, Brlek, P, Kivity, V et al.. Therapeutic Potential and Mechanisms of Mesenchymal Stem Cells in Coronary Artery Disease: Narrative Review. Int J Mol Sci. 2025;26 (11):. doi: 10.3390/ijms26115414. PubMed PMID:40508220 PubMed Central PMC12156323.
  18. Dipalma, G, Marinelli, G, Palumbo, I, Guglielmo, M, Riccaldo, L, Morolla, R et al.. Mesenchymal Stem Cells in Oral and Maxillofacial Surgery: A Systematic Review of Clinical Applications and Regenerative Outcomes. J Clin Med. 2025;14 (11):. doi: 10.3390/jcm14113623. PubMed PMID:40507385 PubMed Central PMC12155250.
  19. Zhao, Y, He, J, Liang, C, Hong, M, Liao, L, Su, X et al.. G-CSF/laponite/collagen composite inducing stem cells of apical papilla homing for dental pulp regeneration. Dent Mater. 2025; :. doi: 10.1016/j.dental.2025.06.001. PubMed PMID:40506328 .
  20. Yu, JL, Yang, C, Liu, L, Lin, A, Guo, SJ, Tian, WD et al.. Optimal good manufacturing practice-compliant production of dental follicle stem cell sheet and its application in Sprague-Dawley rat periodontitis. World J Stem Cells. 2025;17 (5):104116. doi: 10.4252/wjsc.v17.i5.104116. PubMed PMID:40503360 PubMed Central PMC12149792.
  21. Jiang, YS, Wei, WS, Xie, DT, Guo, G. Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging. World J Stem Cells. 2025;17 (5):101638. doi: 10.4252/wjsc.v17.i5.101638. PubMed PMID:40503359 PubMed Central PMC12149794.
  22. Mito, M, Tsuchiya, A, Ishii, S, Tonouchi, T, Furuyama, K, Jinbo, R et al.. Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice. Biochem Biophys Rep. 2025;42 :102061. doi: 10.1016/j.bbrep.2025.102061. PubMed PMID:40503100 PubMed Central PMC12152499.
  23. Vohra, M, Maiti, S, Shah, KK, Raju, L, Nallaswamy, D, Eswaramoorthy, R et al.. Influence of L-arginine on hydroxyapatite-based ovine bone graft - An in vitro evaluation of surface characteristics and cell viability. Dent Res J (Isfahan). 2025;22 :19. doi: 10.4103/drj.drj_263_24. PubMed PMID:40502445 PubMed Central PMC12155389.
  24. Wang, Y, Zhu, L, Liu, H, Jin, S, Wu, X, Wu, T et al.. Prim-O-Glucosylcimifugin Repairs Diabetic Tendon Injury by Rescuing Tendon Stem/Progenitor Cell Hypofunction Through AMPK Pathway Activation. Adv Healthc Mater. 2025; :e2501239. doi: 10.1002/adhm.202501239. PubMed PMID:40500937 .
  25. Pires, RS, Santos, MS, Miguel, F, da Silva, CL, Silva, JC. Electrical Stimulation of Oral Tissue-Derived Stem Cells: Unlocking New Potential for Dental and Periodontal Regeneration. Cells. 2025;14 (11):. doi: 10.3390/cells14110840. PubMed PMID:40498016 PubMed Central PMC12155425.
  26. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Mechanistic insights into dental stem cells-derived exosomes in regenerative endodontics. Int Endod J. 2025; :. doi: 10.1111/iej.14269. PubMed PMID:40497413 .
  27. Zhang, Q, He, P, Shi, S, Xu, Q, Granquist, EJ, Winkelstein, BA et al.. Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration. J Nanobiotechnology. 2025;23 (1):434. doi: 10.1186/s12951-025-03515-7. PubMed PMID:40495198 PubMed Central PMC12150548.
  28. Wang, Z, Wang, M, Luo, Z, Fu, Y, Zhu, X, Li, D et al.. VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation. Int Dent J. 2025;75 (4):100850. doi: 10.1016/j.identj.2025.100850. PubMed PMID:40494210 .
  29. Rajasekar, V, Abdalla, MM, Neelakantan, P, Yiu, CKY. Cellular dynamics and signalling mechanisms in dentine repair: A narrative review. Int Endod J. 2025; :. doi: 10.1111/iej.14261. PubMed PMID:40491185 .
  30. Murugesan, A, Ravi, S, Ekambaram, M, Balakrishnan, S, Indrapriyadharshini, K. Tumor hypoxia and cancer stem cell markers expression in oral squamous cell carcinoma- An Immunohistochemical analysis. Indian J Pathol Microbiol. 2025; :. doi: 10.4103/ijpm.ijpm_174_24. PubMed PMID:40485407 .
  31. Velhal, K, Sah, P, Raut, R, Yamgar, R, Naidu, R, Kalra, P et al.. A novel approach: inclusion complex-capped gold nanoparticles for paclitaxel delivery in triple-negative breast cancer. Med Oncol. 2025;42 (7):243. doi: 10.1007/s12032-025-02805-2. PubMed PMID:40483654 .
  32. Takahashi, G, Maeda, M, Shinozaki, K, Harada, G, Ito, S, Miyaoka, Y et al.. High-throughput robotic isolation of human iPS cell clones reveals frequent homozygous induction of identical genetic manipulations by CRISPR-Cas9. Stem Cell Res Ther. 2025;16 (1):295. doi: 10.1186/s13287-025-04414-2. PubMed PMID:40483517 PubMed Central PMC12145606.
  33. Liang, S, Du, S, Zheng, Y, Xia, D, Zhou, Y. Biodegradable Zn-xY alloys with enhanced osteogenesis and angiogenesis effects for bone implant applications. Acta Biomater. 2025; :. doi: 10.1016/j.actbio.2025.05.048. PubMed PMID:40482983 .
  34. Qin, TX, Zhu, YY, Ng, WH, Ng, SK, Chek, MF, Tang, KD et al.. Adipocytes promote cancer stemness properties in oral squamous cell carcinoma through C3/C3AR axis and sphingolipid metabolism. Cancer Lett. 2025;628 :217848. doi: 10.1016/j.canlet.2025.217848. PubMed PMID:40482908 .
  35. Shan, C, Wang, W, Lu, H, Wang, K, Wang, T, Zhang, Z et al.. A spatially organized Cd24a+/Pax9+ stem cell core governs postnatal tooth establishment. Sci Adv. 2025;11 (23):eadu5653. doi: 10.1126/sciadv.adu5653. PubMed PMID:40479070 PubMed Central PMC12143388.
  36. Tian, J, Lou, Y, Li, M, Duan, Y, Liu, H, Chen, C et al.. Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism. Bioact Mater. 2025;51 :179-196. doi: 10.1016/j.bioactmat.2025.04.034. PubMed PMID:40475085 PubMed Central PMC12137177.
  37. Li, Y, Wang, X, Weng, S, Xia, C, Meng, X, Yang, C et al.. Cardiomyocyte pyroptosis inhibited by dental pulp-derived mesenchymal stem cells via the miR-19a-3p/IRF-8/MAPK pathway in ischemia-reperfusion. Chin Med J (Engl). 2025; :. doi: 10.1097/CM9.0000000000003623. PubMed PMID:40474332 .
  38. Al-Masoody, AH, Asadi, N, Mohammadpour, H, Hodjat, M, Kashi, TSJ. Effects of combining hyaluronic acid hydrogel with injectable platelet rich fibrin on apical papilla stem cells proliferation and differentiation. BMC Oral Health. 2025;25 (1):913. doi: 10.1186/s12903-025-06236-3. PubMed PMID:40474136 PubMed Central PMC12142928.
  39. Saini, M, Paliwal, J, Sharma, V, Gupta, N, Meena, KK, Singhal, P et al.. Influence of PEEK surface modification with titanium for improving osseointegration: an in vitro study. Sci Rep. 2025;15 (1):19801. doi: 10.1038/s41598-025-05214-7. PubMed PMID:40473857 PubMed Central PMC12141525.
  40. Ramesh, P, Pena, R, Morrissey, JM, Moskwa, N, Tubbesing, K, Zhang, X et al.. Cryoelectrospun elastin-alginate scaffolds as potential cell delivery vehicles for mesenchymal stromal cell therapy. Sci Rep. 2025;15 (1):19847. doi: 10.1038/s41598-025-03822-x. PubMed PMID:40473688 PubMed Central PMC12141519.
  41. Wang, X, Dong, C, Lamichhane, B, Thapa, S, Zhang, Y, Gupta, S et al.. Din Oversees Mesenchymal Stem Cell Homeostasis in Mouse Incisors. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-6568233/v1. PubMed PMID:40470223 PubMed Central PMC12136219.
  42. Lu, X, Liu, Y, Dai, L, Cheng, B, Li, Y. EGFL6 Promotes Angiogenesis and Odontogenesis in Pulp Regeneration via MAPK Signaling Pathways. Curr Stem Cell Res Ther. 2025; :. doi: 10.2174/011574888X362657250528171158. PubMed PMID:40468928 .
  43. Chen, S, Huang, G, Guo, Z, Guo, Z, Cao, C, Zhao, G et al.. Tumor-associated Schwann cells promote salivary adenoid cystic carcinoma stem-like reprogramming via IGF2/IGF1R induced histone H3 lysine 18 lactylation. Cancer Lett. 2025;628 :217847. doi: 10.1016/j.canlet.2025.217847. PubMed PMID:40466903 .
  44. Tangrodchanapong, T, Jiso, A, Changkaew, P, Khachonkham, S, Thongsuk, A, Chodchavanchai, T et al.. Radioprotective effects of asiaticoside and asiatic acid in neural stem cells derived from human stem cells from apical papilla through increasing dose-reduction factor and their lowering effects on SH-SY5Y cell viability. PLoS One. 2025;20 (6):e0325480. doi: 10.1371/journal.pone.0325480. PubMed PMID:40465752 PubMed Central PMC12136317.
  45. Wang, Y, Wang, H, Tan, J, Cao, Z, Wang, Q, Wang, H et al.. Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases. Mol Biomed. 2025;6 (1):34. doi: 10.1186/s43556-025-00277-4. PubMed PMID:40465163 PubMed Central PMC12137892.
  46. Hu, J, Zhao, L, Liu, X, Xu, L, Zhao, H. Exploring research hotspots and trends in periodontal regeneration from 2000 to 2023: a bibliometric analysis. Saudi Dent J. 2025;37 (4-6):15. doi: 10.1007/s44445-025-00023-0. PubMed PMID:40464866 PubMed Central PMC12137857.
  47. Shao, J, Xu, W, Tao, N, Du, H, He, Z, Wang, L et al.. Hepatocyte Growth Factor-Modified Dental Pulp Stem Cells Potentially Regulate Novel Renal Fibrosis-Associated Gene via PI3K/AKT/GSK3β Pathway to Alleviate Renal Fibrosis. Hum Gene Ther. 2025; :. doi: 10.1089/hum.2025.044. PubMed PMID:40462757 .
  48. Di, T, Wang, L, Feng, C, Xu, J, Shao, B, Cheng, B et al.. ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling. Stem Cell Res Ther. 2025;16 (1):283. doi: 10.1186/s13287-025-04382-7. PubMed PMID:40462244 PubMed Central PMC12135250.
  49. Jiang, Y, Zhang, Z, Ren, K, Zhou, S, Qiao, Y, Huang, W et al.. Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations. J Biol Eng. 2025;19 (1):52. doi: 10.1186/s13036-025-00524-w. PubMed PMID:40462207 PubMed Central PMC12135596.
  50. Khokhani, P, Warmink, K, Kruyt, M, Weinans, H, Gawlitta, D. Mixtures of PRR Ligands Partly Mimic the Immunomodulatory Response of γi Staphylococcus aureus, Enhancing Osteogenic Differentiation of Human Mesenchymal Stromal Cells. Stem Cells Int. 2025;2025 :1445520. doi: 10.1155/sci/1445520. PubMed PMID:40458752 PubMed Central PMC12127128.
  51. Wang, B, Kong, Y, Dong, H, Lai, F, Guo, Z, Lin, L et al.. Exosomal circ_0003057 promotes osteo/odontogenic differentiation of hDPSCs by binding with EIF4A3 through upregulated parental gene ANKH. Int Endod J. 2025; :. doi: 10.1111/iej.14262. PubMed PMID:40457889 .
  52. Kato, T, Ogura, Y, Kamae, C, Yeh, TW, Okano, T, Take, J et al.. Centralized rapid genetic diagnosis of combined immunodeficiency in Japan. Pediatr Int. 2025;67 (1):e70085. doi: 10.1111/ped.70085. PubMed PMID:40457861 PubMed Central PMC12130913.
  53. Gultekin, SE, von Brandenstein, M, Baris, E, Atak Secen, I, Arslan Bozdag, L, Goebel, H et al.. The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker. Oral Dis. 2025; :. doi: 10.1111/odi.15396. PubMed PMID:40457691 .
  54. Alauti, RY, Mukhtar, AH, Alasqah, M, Alenazi, MH, Gufran, K. Efficacy of Different Concentrations of Melatonin on Cultured Human Periodontal Ligament Stem Cells. Med Sci Monit Basic Res. 2025;31 :e948551. doi: 10.12659/MSMBR.948551. PubMed PMID:40457609 PubMed Central PMC12144917.
  55. Lin, L, Dong, H, Lai, F, Zhang, J, Wang, B, Lv, X et al.. circ_0002456/FUS interaction inhibits NF-κB signaling to attenuate DNA damage and inflammatory responses in hDPSCs. Stem Cell Res Ther. 2025;16 (1):276. doi: 10.1186/s13287-025-04391-6. PubMed PMID:40457486 PubMed Central PMC12131344.
  56. Liu, Y, Liu, Y, Ye, Z, Wang, X, Li, J, Mei, PL et al.. Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps. Stem Cell Res Ther. 2025;16 (1):272. doi: 10.1186/s13287-025-04407-1. PubMed PMID:40457321 PubMed Central PMC12131630.
  57. Zhang, Y, Si, C, Yang, C, Wang, A, Yu, B. Porphyromonas gingivalis induced DNA oxidative stress damage by iron overload to deplete CTCF expression and prevent osteogenic differentiation of periodontal ligament stem cells. J Mol Histol. 2025;56 (3):182. doi: 10.1007/s10735-025-10467-7. PubMed PMID:40455363 .
  58. Ma, Y, Yang, L, Gao, Y, Bian, J, Chen, Y, Xie, H et al.. 10-MDP in dentin bonding: a novel role in pulp protection via modulation of dental pulp stem cell behavior. Clin Oral Investig. 2025;29 (6):326. doi: 10.1007/s00784-025-06389-z. PubMed PMID:40455111 .
  59. Balfaki, M, Salimi, E. Revolutionary Regeneration Therapy Utilizing Dental Stem Cells and State-of-the-Art Nanotechnology Devices to Heal Injured Teeth and Tissues. Avicenna J Med Biotechnol. 2025;17 (2):83-97. doi: 10.18502/ajmb.v17i2.18559. PubMed PMID:40453915 PubMed Central PMC12123186.
  60. Chansaenroj, J, Nowwarote, N, Sawangmake, C, Thanyasrisung, P, Khlongwanitchakul, K, Srisa, C et al.. Influence of Osteopontin-Coated Surface on Osteoblast Behaviour Relevant to Dental Implant Integration. Int J Dent. 2025;2025 :9929498. doi: 10.1155/ijod/9929498. PubMed PMID:40453761 PubMed Central PMC12124924.
  61. de Souza, JR, Rahimnejad, M, Soares, IPM, Anselmi, C, de Oliveira, PHC, Dos Reis-Prado, AH et al.. 3D Printing β-TCP-laden GelMA/Alginate Interpenetrating-Polymer-Network Biomaterial Inks for Bone Tissue Engineering. Bioprinting. 2025;49 :. doi: 10.1016/j.bprint.2025.e00413. PubMed PMID:40453455 PubMed Central PMC12121956.
  62. Park, S, Pascal, AB, Eisig, SB, Feng, M, Jeong, HJ, Zhu, E et al.. Icariin-Releasing 3-Dimensionally Printed Scaffolds for Alveolar Cleft Reconstruction. Biomater Res. 2025;29 :0199. doi: 10.34133/bmr.0199. PubMed PMID:40452886 PubMed Central PMC12123084.
  63. Hsin, J, Yazejian, RM, Pajanoja, C, Kerosuo, L. Shared and individual expression patterns of pluripotency genes in the developing chick embryo during neurulation and beyond. Differentiation. 2025;144 :100866. doi: 10.1016/j.diff.2025.100866. PubMed PMID:40449070 .
  64. Rahman, IU, Khan, MTM, Ali, Z, Ahmad, S, Shahid, M, Zafar, S et al.. Thalidomide confers therapeutic benefit in beta thalassemia patients by enhancing hemoglobin and hematopoietic gene expression: A non-randomized clinical trial. Blood Cells Mol Dis. 2025;113-114 :102936. doi: 10.1016/j.bcmd.2025.102936. PubMed PMID:40446669 .
  65. Tang, Q, Li, L, Li, Y, Wang, A, Li, H, Wang, L et al.. Distinct BMP-smad signaling outputs confer diverse functions in dental mesenchyme. Development. 2025; :. doi: 10.1242/dev.204563. PubMed PMID:40446216 .
  66. Takeshova, T, Kurmanalina, M, Aitmukhanbetova, A, Mussin, NM, Tanideh, N, Tamadon, A et al.. Bioactive Glass in Dentistry: A Bibliometric Analysis of Trends, Impact, and Future Directions. Tissue Eng Part B Rev. 2025; :. doi: 10.1089/ten.teb.2025.0016. PubMed PMID:40444334 .
  67. Wang, LJ, Zhou, J, Zhou, CC. [Research progress in mitochondrial regulation of osteogenic and odontogenic differentiation of dental-derived mesenchymal stem cells]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2025;60 (6):662-668. doi: 10.3760/cma.j.cn112144-20250116-00022. PubMed PMID:40443322 .
  68. Hayashi, K, Teramoto, E, Taleb Alashkar, AN, Lou, Z, Moriyama, M, Ishikawa, K et al.. Antibacterial and Angiogenic Copper Phosphate-Modified Carbonate Apatite Honeycomb Plugs for Enhanced Gingival and Alveolar Bone Regeneration. ACS Appl Mater Interfaces. 2025;17 (23):33340-33356. doi: 10.1021/acsami.5c01022. PubMed PMID:40442031 .
  69. Wang, YN, Liu, S. Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia. BMC Oral Health. 2025;25 (1):823. doi: 10.1186/s12903-025-06218-5. PubMed PMID:40437476 PubMed Central PMC12117928.
  70. Rungruang, P, Sroyraya, M, Sansri, V. Protective Role of Whey Protein Isolate on MPP+-Induced Differentiation of SH-SY5Y Cells by Modulating the Nrf2 Antioxidant Pathway. Molecules. 2025;30 (10):. doi: 10.3390/molecules30102207. PubMed PMID:40430379 PubMed Central PMC12114080.
  71. Oliveira, M, Angelova, L, Avdeev, G, Grenho, L, Fernandes, MH, Daskalova, A et al.. Femtosecond Laser-Engineered β-TCP Scaffolds: A Comparative Study of Green-Synthesized AgNPs vs. Ion Doping Against S. aureus for Bone Regeneration. Int J Mol Sci. 2025;26 (10):. doi: 10.3390/ijms26104888. PubMed PMID:40430028 PubMed Central PMC12112484.
  72. Bocachica-Adorno, AL, Aponte-Ramos, AY, Rivera-Fuentes, PS, Espinosa-Ponce, NP, Arroyo-Cruz, LV, Ling, T et al.. Ergosterol Peroxide Disrupts Triple-Negative Breast Cancer Mitochondrial Function and Inhibits Tumor Growth and Metastasis. Int J Mol Sci. 2025;26 (10):. doi: 10.3390/ijms26104588. PubMed PMID:40429733 PubMed Central PMC12111164.
  73. Hsieh, KP, Naruphontjirakul, P, Chen, JH, Ko, CS, Lin, CW, Su, WT et al.. Incorporation of Zinc Oxide Nanoparticles Biosynthesized from Epimedium brevicornum Maxim. into PCL Nanofibers to Enhance Osteogenic Differentiation of Periodontal Ligament Stem Cells. Materials (Basel). 2025;18 (10):. doi: 10.3390/ma18102295. PubMed PMID:40429032 PubMed Central PMC12113110.
  74. Lee, H, Kim, JH, Lee, HJ, Park, JB. Impact of Dexamethasone on Three-Dimensional Stem Cell Spheroids: Morphology, Viability, Osteogenic Differentiation. Medicina (Kaunas). 2025;61 (5):. doi: 10.3390/medicina61050871. PubMed PMID:40428829 PubMed Central PMC12113056.
  75. Cao, Y, Wang, Y, Xia, D. Investigating the Associations Between Hmga2 Overexpression, R-Loop Reduction, and Bone Loss in Aging Mice. Medicina (Kaunas). 2025;61 (5):. doi: 10.3390/medicina61050820. PubMed PMID:40428778 PubMed Central PMC12113323.
  76. Du, Z, Feng, L, Zhang, Y, Peng, X, Zhang, S, Zhao, R et al.. Route of Application and Dose Evaluation of Dental Pulp Stem Cells for the Treatment of Sialadenitis Caused by Sjögren's Syndrome: A Preclinical Study. Biomedicines. 2025;13 (5):. doi: 10.3390/biomedicines13051068. PubMed PMID:40426896 PubMed Central PMC12109166.
  77. Ishikawa, K, Tani, S, Sakai, N, Kudo, Y, Horiuchi, H, Kimura-Suda, H et al.. Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling. Bone Res. 2025;13 (1):56. doi: 10.1038/s41413-025-00433-0. PubMed PMID:40425548 PubMed Central PMC12116787.
  78. Zhang, Y, Zheng, H, Zhao, Y, Du, C, Zhang, J, Liu, J et al.. Deciphering the Distinct Roles of Molecular and Supramolecular Chirality in Osteogenic Differentiation of Mesenchymal Stem Cells in 3D Hydrogels. ACS Nano. 2025;19 (22):20564-20577. doi: 10.1021/acsnano.5c00875. PubMed PMID:40425514 .
  79. Suh, HN, Ji, JY, Heo, JS. Metformin-Enhanced Secretome from Periodontal Ligament Stem Cells Promotes Functional Recovery in an Inflamed Periodontal Model: In Vitro Study. J Funct Biomater. 2025;16 (5):. doi: 10.3390/jfb16050177. PubMed PMID:40422841 PubMed Central PMC12112599.
  80. Maher, S, Ignjatović, NL, Lazarević, M, Petrović, S, Žekić, A, Losic, D et al.. Combined Effects of Dual-Scale Modified Surface with Micro- and Nanostructures on the Cellular Biocompatibility, Osteoinduction, and Antibacterial Properties of Titanium Implants. J Funct Biomater. 2025;16 (5):. doi: 10.3390/jfb16050157. PubMed PMID:40422822 PubMed Central PMC12111884.
  81. Zheng, P, Jia, Q, Li, Z, Jiang, HB, Zhou, L. Enhanced osteogenic and angiogenic capabilities of adipose-derived stem cells in fish collagen scaffolds for treatment of femoral head osteonecrosis. Sci Rep. 2025;15 (1):18300. doi: 10.1038/s41598-025-03015-6. PubMed PMID:40419685 PubMed Central PMC12106632.
  82. Suzuki, M, Kamitakahara, M, Kihara, W, Xie, C, Kato, H, Fukawa, Y et al.. Osteotropic properties of mesenchymal stromal cells generated in Masquelet's induced membrane technique. Sci Rep. 2025;15 (1):18304. doi: 10.1038/s41598-025-02576-w. PubMed PMID:40419580 PubMed Central PMC12106703.
  83. Aljabri, MY, Alhazmi, YA, Elsayyad, SA, Saber, SM, Shamel, M. Gingival Stem Cell-Conditioned Media and Low-Level Laser Therapy Enhance Periodontal Ligament Stem Cells Function by Upregulating Wnt and TGF-β Pathway Components: An In Vitro Study. Clin Exp Dent Res. 2025;11 (3):e70151. doi: 10.1002/cre2.70151. PubMed PMID:40417964 PubMed Central PMC12104865.
  84. Heo, SC, Shin, HW, Lee, DJ, Garcia-Godoy, F, Keum, BR, Kwon, YH et al.. Tartaric acid-branched polyethyleneimine carbon dots promote repair of bone defect via osteogenic differentiation. Regen Biomater. 2025;12 :rbaf030. doi: 10.1093/rb/rbaf030. PubMed PMID:40416649 PubMed Central PMC12098262.
  85. Thornton, JR, Capurro, A, Harwood, S, Henderson, TC, Unsworth, A, Görtler, F et al.. Screening of candidate analgesics using a patient-derived human iPSC model of nociception identifies putative compounds for therapeutic treatment. Clin Transl Med. 2025;15 (5):e70339. doi: 10.1002/ctm2.70339. PubMed PMID:40415465 PubMed Central PMC12104564.
  86. Yang, Y, Hu, X, Jing, M, Zhu, X, Liu, X, Tan, W et al.. Osteomodulin modulates the inflammatory responses via the interleukin-1 receptor 1/nuclear factor-κB signaling pathway in dental pulpitis. Int J Oral Sci. 2025;17 (1):41. doi: 10.1038/s41368-025-00369-5. PubMed PMID:40414936 PubMed Central PMC12104430.
  87. Fu, Y, Okawa, H, Vinaikosol, N, Mori, S, Limraksasin, P, Nattasit, P et al.. Shaking culture attenuates circadian rhythms in induced pluripotent stem cells during osteogenic differentiation through the TEAD-Fbxl3-CRY axis. Cell Death Discov. 2025;11 (1):252. doi: 10.1038/s41420-025-02533-6. PubMed PMID:40413171 PubMed Central PMC12103599.
  88. Sherif, MA, Anter, E, Graetz, C, El-Sayed, KF. Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2025;25 (1):772. doi: 10.1186/s12903-025-06115-x. PubMed PMID:40410805 PubMed Central PMC12100897.
  89. Guerrero, J, Maevskaia, E, Pfister, P, Dominguez, AP, Ghayor, C, Bhattacharya, I et al.. Mineralized osteoblast-derived exosomes and 3D-printed ceramic-based scaffolds for enhanced bone healing: A preclinical exploration. Acta Biomater. 2025; :. doi: 10.1016/j.actbio.2025.05.051. PubMed PMID:40409510 .
  90. Tanegashima, K, Esashi, E, Ishida, K, Kotaki, A, Iwase, R, Hasebe, M et al.. CXCL14 is an essential modulator of TLR9 agonist-induced antitumor immune responses. J Immunol. 2025; :. doi: 10.1093/jimmun/vkaf080. PubMed PMID:40404173 .
  91. Azarsina, M, Arany, P, Marques, MM, Abrahamse, H, Dehghani, N, Azarsina, S et al.. Photobiomodulation for stem cell modulation and regenerative medicine -WALT position paper 2025. J Dent. 2025;159 :105832. doi: 10.1016/j.jdent.2025.105832. PubMed PMID:40403870 .
  92. Kumar, R, Das, S, Minka, W, Reiter, C, Pereira, R, Fuhrmann, D et al.. The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis. Bone. 2025;198 :117539. doi: 10.1016/j.bone.2025.117539. PubMed PMID:40403823 .
  93. Hassan, A, Elbattawy, W, Sanaa, D, Nawwar, A, Magdeldin, S, Mokhtar, M et al.. Retinol-Augmented PRF Versus PRF Alone in Periodontal Regeneration: A Randomized Clinical Trial. J Periodontal Res. 2025; :. doi: 10.1111/jre.13404. PubMed PMID:40400285 .
  94. Liu, Y, Dissanayaka, WL, Yiu, C. Therapeutic implications of mitochondrial transfer on stem cell fate in regenerative medicine. J Transl Med. 2025;23 (1):568. doi: 10.1186/s12967-025-06472-9. PubMed PMID:40399970 PubMed Central PMC12093763.
  95. Moon, HK, Han, SJ, Li, CY, Won, JE, Shim, JS. Cytotoxicity evaluation of dental cements containing resin: Effects of the degree of conversion on cellular responses. J Prosthodont Res. 2025; :. doi: 10.2186/jpr.JPR_D_24_00299. PubMed PMID:40399069 .
  96. Jalahi, M, Shahijani, S, Jalahi, A, Hosseini, M, Farzam, M, Dehghanian, AR et al.. Evaluation of the healing effect of kappa-carrageenan combined with dental pulp stem cell-derived exosomes on induced knee osteoarthritis in male rats. Knee. 2025;56 :11-21. doi: 10.1016/j.knee.2025.04.020. PubMed PMID:40398309 .
  97. Zeng, X, He, P. Spatio-Temporal Regulation of IGFs in Enamel Development: Molecular Mechanisms From Ameloblast Polarity to Mineralization Homeostasis. Stem Cells Int. 2025;2025 :9665706. doi: 10.1155/sci/9665706. PubMed PMID:40395978 PubMed Central PMC12092154.
  98. Zhang, R, Zhang, J, Liu, L, Wei, T, Qin, Y, Jiang, C et al.. Compressive Force Inhibits Osteogenic Differentiation of Dental Follicle Stem Cells Through Biglycan/Bone Morphogenetic Protein2/Smad1 Signaling Pathway. Stem Cells Dev. 2025;34 (11-12):240-248. doi: 10.1089/scd.2025.0041. PubMed PMID:40395190 .
  99. Talebi, A, Razi, S, Talebi, S, Nourbakhsh, N, Talebi, H, Soroushzadeh, S et al.. Growth and size of stem cells from human exfoliated deciduous teeth cultured in platelet lysate vs. fetal bovine serum for regenerative applications. Eur J Med Res. 2025;30 (1):407. doi: 10.1186/s40001-025-02670-9. PubMed PMID:40394651 PubMed Central PMC12093836.
  100. Peng, X, Zhao, L, Wang, J, Zhang, Y, Liu, Z, Wang, K et al.. Melatonin Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction Through Ameliorating NAD+ Homeostasis of hDPSCs for Cell-Based Therapy. J Pineal Res. 2025;77 (3):e70058. doi: 10.1111/jpi.70058. PubMed PMID:40391773 .
Search PubMed
Email Us

or call: (844) MY-OOTHY

Copyright 2019, OOTHY LLC
a service of GeneCell International

>