Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Iwasaki, A, Hatakeyama, M, Liu, Q, Orimoto, A, Fukuda, T, Kitaoka, T et al.. Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds. Carbohydr Polym. 2025;359 :123593. doi: 10.1016/j.carbpol.2025.123593. PubMed PMID:40306767 .
  2. Umapathy, VR, Natarajan, PM, Swamikannu, B. Regenerative Strategies in Dentistry: Harnessing Stem Cells, Biomaterials and Bioactive Materials for Tissue Repair. Biomolecules. 2025;15 (4):. doi: 10.3390/biom15040546. PubMed PMID:40305324 .
  3. Janbaz, P, Behzadpour, F, Ghanadan, K. Evaluation of the Structural, Biological, and Bone Induction Properties of Sol-Gel-Derived Lithium-Doped 68S Bioactive Glass-An in Vitro Study on Human Dental Pulp Stem Cells. Clin Exp Dent Res. 2025;11 (3):e70139. doi: 10.1002/cre2.70139. PubMed PMID:40304308 .
  4. Surisaeng, T, Wisitrasameewong, W, Champaiboon, C, Sa-Ard-Iam, N, Chanamuangkon, T, Thongnuek, P et al.. BMP-2 mRNA-transfected BMSCs promote superior calvarial bone regeneration. Sci Rep. 2025;15 (1):15022. doi: 10.1038/s41598-025-99979-6. PubMed PMID:40301548 .
  5. Wen, C, Chen, X, Lai, L. Identifying metabolic biomarkers and pathways in pulpitis: a metabolomic study using ultra-high-performance liquid chromatography/orbitrap mass spectrometry. J Appl Oral Sci. 2025;33 :e20240428. doi: 10.1590/1678-7757-2024-0428. PubMed PMID:40298663 .
  6. Gultekin, SE, Arslan Bozdag, L, Odenthal, M, Dienes, HP. Epigenetic Regulation of Dental Follicle Stem Cells in Odontogenic Regeneration. J Cell Mol Med. 2025;29 (9):e70541. doi: 10.1111/jcmm.70541. PubMed PMID:40296331 PubMed Central PMC12037698.
  7. Sleep, SL, Ranjit, E, Gunter, J, Hryciw, DH, Arany, P, George, R et al.. Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study. J Biophotonics. 2025; :e70051. doi: 10.1002/jbio.70051. PubMed PMID:40294940 .
  8. Naidu, P, Das, M, Hansda, S, Prateeksha, P, Howlader, MSI, Siraj, MA et al.. Mechanisms of Ellagic Acid (EA)-Mediated Osteogenic Differentiation of Human Dental Pulp-Derived Stem Cells. ACS Omega. 2025;10 (15):15229-15242. doi: 10.1021/acsomega.4c10642. PubMed PMID:40290905 PubMed Central PMC12019503.
  9. Ma, S, Yao, S, Li, Y, Yang, Y, Tong, T, Zheng, H et al.. A pH-Responsive Polyetheretherketone Implant Modified with a Core-Shell Metal-Organic Framework to Promote Antibacterial and Osseointegration Abilities. Biomater Res. 2025;29 :0188. doi: 10.34133/bmr.0188. PubMed PMID:40290761 PubMed Central PMC12022397.
  10. Anselmi, C, Mendes Soares, IP, Chang, S, Cardoso, LM, de Carvalho, ABG, Dal-Fabbro, R et al.. Quercetin-calcium hydroxide scaffolds modulate dental pulp stem cell response in vitro under a simulated inflammatory environment. Int Endod J. 2025; :. doi: 10.1111/iej.14243. PubMed PMID:40285990 .
  11. Garg, N, Krishna, R, Urs, AB, Kumar, P, Augustine, J. A systematic review on the molecular pathways of Ameloblastic carcinoma when compared to Ameloblastoma. Expert Rev Mol Diagn. 2025; :1-13. doi: 10.1080/14737159.2025.2499180. PubMed PMID:40285826 .
  12. Paraš, S, Petrović, B, Mitić, D, Lazarević, M, Popović Bajić, M, Živković, M et al.. Three-Dimensional-Printed Bone Grafts for Simultaneous Bone and Cartilage Regeneration: A Promising Approach to Osteochondral Tissue Engineering. Pharmaceutics. 2025;17 (4):. doi: 10.3390/pharmaceutics17040489. PubMed PMID:40284484 PubMed Central PMC12030389.
  13. Sillmann, YM, Eber, P, Orbeta, E, Wilde, F, Gross, AJ, Guastaldi, FPS et al.. Milestones in Mandibular Bone Tissue Engineering: A Systematic Review of Large Animal Models and Critical-Sized Defects. J Clin Med. 2025;14 (8):. doi: 10.3390/jcm14082717. PubMed PMID:40283548 PubMed Central PMC12027812.
  14. Boisen, IM, Krarup Knudsen, N, Nielsen, JE, Kooij, I, Bagger, ML, Kaludjerovic, J et al.. Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications. Elife. 2025;13 :. doi: 10.7554/eLife.95545. PubMed PMID:40279260 PubMed Central PMC12029210.
  15. Stieger, RB, Lilaj, B, Hönigl, GP, Pock, S, Cvikl, B. Flow Cytometry Illuminates Dental Stem Cells: a Systematic Review of Immunomodulatory and Regenerative Breakthroughs. Stem Cell Rev Rep. 2025; :. doi: 10.1007/s12015-025-10883-y. PubMed PMID:40279028 .
  16. Zhao, HR, Zhao, JZ, Zhao, N, Xue, LF, Xu, YX, Yue, J et al.. CA1 induced dental follicle stem cells co-culture with dental pulp stem cells and loaded three-dimensional printed PCL/β-TCP scaffold: a novel strategy for alveolar cleft bone regeneration. J Mater Sci Mater Med. 2025;36 (1):37. doi: 10.1007/s10856-025-06889-0. PubMed PMID:40278949 PubMed Central PMC12031973.
  17. Seciu-Grama, AM, Lazăr, SE, Petrescu, S, Mocioiu, OC, Crăciunescu, O, Atkinson, I et al.. Impact of Vitamin D3 Functionalization on the Osteogenic Capacity of Bioinspired 3D Scaffolds Based on Ce-Doped Bioactive Glass and Spongia Agaricina. J Funct Biomater. 2025;16 (4):. doi: 10.3390/jfb16040141. PubMed PMID:40278249 PubMed Central PMC12027579.
  18. Mitic, DD, Milosevic Markovic, MS, Jovanovic, ID, Mancic, DD, Orhan, K, Jokanovic, VR et al.. A Biomimetic Approach to Diode Laser Use in Endodontic Treatment of Immature Teeth: Thermal, Structural, and Biological Analysis. Biomimetics (Basel). 2025;10 (4):. doi: 10.3390/biomimetics10040216. PubMed PMID:40277616 PubMed Central PMC12025333.
  19. Kim, H, Williams, SJ, Colombo, JS. Characterization of Fibronectin-Adherent, Non-Fibronectin-Adherent, and Explant-Derived Human Dental Pulp Stem Cell Populations. Dent J (Basel). 2025;13 (4):. doi: 10.3390/dj13040159. PubMed PMID:40277489 PubMed Central PMC12026221.
  20. Yu, L, Yang, F, Li, C, Ruan, J, Wang, J. Poly(amidoamine) Dendrimers as PotentialTherapeutic Agents for Conservative Treatment of Irreversible Pulpitis. J Endod. 2025; :. doi: 10.1016/j.joen.2025.04.007. PubMed PMID:40274259 .
  21. Zhang, Q, Yi, Y, Chen, T, Ai, Y, Chen, Z, Liu, G et al.. M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis. J Nanobiotechnology. 2025;23 (1):311. doi: 10.1186/s12951-025-03390-2. PubMed PMID:40270025 PubMed Central PMC12020034.
  22. Budi, HS, Handajani, J, Amir, LR, Soekanto, SA, Ulfa, NM, Wulansari, SA et al.. Nanoemulgel Development of Stem Cells from Human Exfoliated Deciduous Teeth-Derived Conditioned Medium as a Novel Nanocarrier Growth Factors. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1806963. PubMed PMID:40267955 .
  23. Belludi, SA, Shaik, S, Pradhan, N, Rema, S. Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report. J Adv Periodontol Implant Dent. 2025;17 (1):54-58. doi: 10.34172/japid.025.3502. PubMed PMID:40265038 PubMed Central PMC12010481.
  24. Hu, M, Wu, L, Wei, E, Pan, X, Zhu, Q, Xiuyun, X et al.. Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway. Stem Cell Res Ther. 2025;16 (1):201. doi: 10.1186/s13287-025-04320-7. PubMed PMID:40264229 PubMed Central PMC12016470.
  25. Hammad, M, Dugué, J, Maubert, E, Baugé, C, Boumédiene, K. Decellularized apple hypanthium as a plant-based biomaterial for cartilage regeneration in vitro: a comparative study of progenitor cell types and environmental conditions. J Biol Eng. 2025;19 (1):38. doi: 10.1186/s13036-025-00502-2. PubMed PMID:40264116 PubMed Central PMC12012941.
  26. Wang, L, Liu, T, Zhang, W, Liu, H, Qi, Y, Li, M et al.. BMAL1-downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway. J Periodontol. 2025; :. doi: 10.1002/JPER.24-0497. PubMed PMID:40259757 .
  27. Acharya, JR, Kumar, S, Girdhar, GA, Patel, S, Parekh, NH, Patadiya, HH et al.. 3D Bioprinting: Shaping the Future of Periodontal Tissue Regeneration and Disease Management. Cureus. 2025;17 (4):e82432. doi: 10.7759/cureus.82432. PubMed PMID:40255528 PubMed Central PMC12007905.
  28. Al Hamwi, G, Alnouri, MW, Verdonck, S, Leonczak, P, Chaki, S, Frischbutter, S et al.. Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. Signal Transduct Target Ther. 2025;10 (1):128. doi: 10.1038/s41392-025-02209-8. PubMed PMID:40254631 PubMed Central PMC12010006.
  29. Ku, D, Yang, Y, Park, Y, Jang, D, Lee, N, Lee, YK et al.. SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases. Cell Rep. 2025;44 (5):115588. doi: 10.1016/j.celrep.2025.115588. PubMed PMID:40253699 .
  30. Takahara, S, Ohkura, N, Yoshiba, N, Baldeon-Gutierrez, R, Gomez-Kasimoto, S, Edanami, N et al.. Influence of Tooth Maturity on Healing Outcomes in Regenerative Endodontics. J Dent Res. 2025; :220345251325826. doi: 10.1177/00220345251325826. PubMed PMID:40251757 .
  31. Karimi, M, Sheibani Pour, M, Etemadi, A, Karimi, MA, Hodjat, M, Chiniforush, N et al.. The photobiomodulation effects of continuous and pulsed blue diode laser on proliferation and osteogenic differentiation of periodontal ligament stem cells. Photochem Photobiol. 2025; :. doi: 10.1111/php.14104. PubMed PMID:40251753 .
  32. Ding, Y, Ran, Y. OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2. BMC Oral Health. 2025;25 (1):595. doi: 10.1186/s12903-025-05927-1. PubMed PMID:40251583 PubMed Central PMC12008942.
  33. Raik, S, Kaur, B, Kumar, S, Rattan, V, Kumar, N, Bhattacharyya, S et al.. Secretome Derived From Mesenchymal Stem Cells Cultured as Monolayer Show Enhanced Bone Regeneration Compared to Secretome From 3D Spheroid - Clues From the Proteome. Adv Healthc Mater. 2025; :e2500885. doi: 10.1002/adhm.202500885. PubMed PMID:40249147 .
  34. Liu, Y, Peng, Y, Chen, L, Xiang, Y, Zhang, X, Song, J et al.. Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane. Int J Oral Sci. 2025;17 (1):33. doi: 10.1038/s41368-024-00345-5. PubMed PMID:40246878 PubMed Central PMC12006293.
  35. Wang, X, Wang, L, Zhou, L, Chen, L, Shi, J, Ge, J et al.. NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming. Int J Oral Sci. 2025;17 (1):34. doi: 10.1038/s41368-025-00362-y. PubMed PMID:40246825 PubMed Central PMC12006529.
  36. Soe, ZC, Nan, DN, Wahyudi, R, Vongsutilers, V, Kamolratanakul, P, Everts, V et al.. Asiaticoside Loaded Nanosponges Hydrogel Has an Anti-inflammatory Effect and Promotes Human Dental Pulp Regeneration. J Endod. 2025; :. doi: 10.1016/j.joen.2025.04.004. PubMed PMID:40246141 .
  37. Hajialigol, A, Azizi, G, Alan, MS, Soltani, A, Arabian, Z, Tamiji, M et al.. Dominant-negative versus Gain-of-function STAT3 Defects: A Systematic Review on Epidemiological, Clinical, Immunological and Molecular Aspects. J Allergy Clin Immunol Pract. 2025; :. doi: 10.1016/j.jaip.2025.04.014. PubMed PMID:40246075 .
  38. Fernández-Pérez, AG, Herrera-González, A, López-Naranjo, EJ, Martínez-Álvarez, IA, Uribe-Rodríguez, D, Ramírez-Arreola, DE et al.. Extracellular Vesicles from Different Mesenchymal Stem Cell Types Exhibit Distinctive Surface Protein Profiling and Molecular Characteristics: A Comparative Analysis. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26073393. PubMed PMID:40244251 PubMed Central PMC11989379.
  39. Musílková, J, Beran, M, Sedlář, A, Slepička, P, Bartoš, M, Kolská, Z et al.. Composite Polylactide/Polycaprolactone Foams with Hierarchical Porous Structure for Pre-Vascularized Tissue Engineering. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072974. PubMed PMID:40243624 PubMed Central PMC11988939.
  40. Palazzo, E, Lotti, R, Quadri, M, Pincelli, C, Marconi, A. IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory Phenotype. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072989. PubMed PMID:40243580 PubMed Central PMC11988555.
  41. Srimaneepong, V, Trachoo, V, Phothichailert, S, Srithanyarat, SS, Mahanonda, R, Norbert, H et al.. Evaluating Surface Properties and Cellular Responses to Surface-Treated Different Triple Periodic Minimal Surface L-PBF Ti6Al4V Lattices for Biomedical Devices. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072960. PubMed PMID:40243578 PubMed Central PMC11988758.
  42. Yang, H, Yuan, F, Song, J, Huang, Y, Shan, Z, Fan, Z et al.. m6A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072920. PubMed PMID:40243520 PubMed Central PMC11988903.
  43. Lin, TY, Mishra, VK, Dubey, R, Chaturvedi, TP, Narayan, SA, Fang, HW et al.. Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025; :. doi: 10.5507/bp.2025.008. PubMed PMID:40242907 .
  44. Del Vecchio, V, Sanchez-Pajares, IR, Panda, SK, Rehman, A, De Falco, V, Nigam, A et al.. Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma. Sci Rep. 2025;15 (1):13137. doi: 10.1038/s41598-025-98003-1. PubMed PMID:40240816 PubMed Central PMC12003764.
  45. Kandettu, A, Ghosal, J, Tharayil, JS, Kuthethur, R, Mallya, S, Narasimhamurthy, RK et al.. Inhibition of mitochondrial genome-encoded mitomiR-3 contributes to ZEB1 mediated GPX4 downregulation and pro-ferroptotic lipid metabolism to induce ferroptosis in breast cancer cells. Free Radic Biol Med. 2025;234 :151-168. doi: 10.1016/j.freeradbiomed.2025.04.019. PubMed PMID:40239722 .
  46. Manokawinchoke, J, Limraksasin, P, Limjeerajarus, CN, Limjeerajarus, N, Samaranayake, LP, Egusa, H et al.. Mechanical Force Induces Osteogenic Differentiation of Murine Induced Pluripotent Stem Cells via TGF-β Signalling. Orthod Craniofac Res. 2025; :. doi: 10.1111/ocr.12933. PubMed PMID:40238110 .
  47. Wu, W, Xu, Z, Zhang, Y, Zhang, X, Huang, X, Xie, Z et al.. KLF6-mediated glutamine metabolism governs odontogenic differentiation and matrix mineralization of dental pulp stem cells. Stem Cell Res Ther. 2025;16 (1):179. doi: 10.1186/s13287-025-04308-3. PubMed PMID:40234972 PubMed Central PMC12001474.
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