Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Yang, Y, Wang, Y, Miao, Y, Luo, Z, Niu, L, Liu, R et al.. R-Loops Mediated Odontogenic Differentiation of hDPSCs by Activating the cGAS-STING Pathway Under Inflammatory Microenvironment. Oral Dis. 2026; :. doi: 10.1111/odi.70379. PubMed PMID:42286959 .
  2. Greaney, AM, Orr, JC, Moore, SKL, Ikonomou, L, Weiss, DJ, Ryan, AL et al.. 20 years of Progress in Stem Cells, Cell Therapy, and Bioengineering in Lung Biology and Diseases. Am J Respir Cell Mol Biol. 2026; :. doi: 10.1093/ajrcmb/aanag126. PubMed PMID:42286350 .
  3. Liang, C, Liu, Z, Li, J, Han, C, Gao, Y, Zhou, B et al.. Human CD24+ dental papilla cells are competent seed cells for dentin-pulp regeneration via BMP2/SIRT1 axis. Nat Commun. 2026; :. doi: 10.1038/s41467-026-74348-7. PubMed PMID:42285987 .
  4. Zhang, N, Huang, Q, Shen, S, Tu, J, Yang, W, Huang, C et al.. Preliminary study on the effect of compressive stress on the angiogenic ability of dental pulp cells. Tissue Cell. 2026;103 :103670. doi: 10.1016/j.tice.2026.103670. PubMed PMID:42284732 .
  5. Noorbakhsh, SAA, Pourmohammadi-Nejad, F, Pirsadeghi, A, Yousefi-Ahmadipour, A. Comparative Analysis of Stemness and Differentiation Gene Expression in Mesenchymal Stem Cells from Permanent and Deciduous Teeth: An In Vitro Study to Evaluate Implications for Regenerative Dentistry. Biochem Genet. 2026; :. doi: 10.1007/s10528-026-11411-4. PubMed PMID:42283766 .
  6. Muthusamy, M, George, B, Alexander, D, Sen, S, Janya, S, Rajanna, BD et al.. Stem cell-based scaffolds using dental pulp and adipose-derived stem cells in periodontal regeneration: Evidence from preclinical or clinical studies. Bioinformation. 2026;22 (4):2015-2019. doi: 10.6026/973206300222015. PubMed PMID:42282350 PubMed Central PMC13252327.
  7. Dutta, BSV, Shete, O, Venkataramani, A, Nemane, A, Kharade, PP, T S, P et al.. Human mesenchymal stem cell differentiation on bioactive glass-coated implants. Bioinformation. 2026;22 (4):2533-2538. doi: 10.6026/973206300222533. PubMed PMID:42282328 PubMed Central PMC13252332.
  8. Zeppieri, M, Capobianco, M, Visalli, F, Khouyyi, M, Gagliano, C, Cappellani, F et al.. Stem cell transplantation in head and neck oncology: Integrating oncologic treatment and maxillofacial reconstruction. World J Transplant. 2026;16 (2):117675. doi: 10.5500/wjt.v16.i2.117675. PubMed PMID:42281868 PubMed Central PMC13248171.
  9. Suciu, TS, Bran, S, Berindan-Neagoe, I, Raduly, L, Zanoaga, O, Budisan, L et al.. Comparative Effects of Escherichia coli vs. Porphyromonas gingivalis Lipopolysaccharides on Osteogenic Differentiation and the Expression of lncRNAs in Periodontal Ligament Stem Cells. Int J Mol Sci. 2026;27 (11):. doi: 10.3390/ijms27115006. PubMed PMID:42278535 .
  10. Askari, N, Yahyapour, A, Bayat, M, Hosseini, SS. Pistacia atlantica subsp. mutica essencial oil enhances proliferation and telomerase activity in senescent mesenchymal stem cells. BMC Complement Med Ther. 2026; :. doi: 10.1186/s12906-026-05331-4. PubMed PMID:42277759 .
  11. Yu, L, Xia, K, Wang, Y, Hu, Z, Liu, J, Zou, S et al.. HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation. Stem Cell Reports. 2026; :102955. doi: 10.1016/j.stemcr.2026.102955. PubMed PMID:42276061 .
  12. El Hajj, S, Gorin, C, Ntaté, MB, Lesieur, R, Casas, E, Chaussain, C et al.. SHEDs and BMSCs exhibit distinct lineage preferences in HUVECs dynamic spheroid co-cultures: vascular versus osteogenic commitment. Bioeng Transl Med. 2026;11 (3):e70091. doi: 10.1002/btm2.70091. PubMed PMID:42272959 PubMed Central PMC13247431.
  13. Luo, Y, Qin, Q, She, W, Wang, X, Li, X, Shu, C et al.. Dental Pulp Stem Cell-Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway. Cell Prolif. 2026; :e70248. doi: 10.1111/cpr.70248. PubMed PMID:42272134 .
  14. Tavoosi, S, Rahgozar, S, Ahmadvand, M, Jarahian, M, Azadmanesh, K. Ex vivo evaluation of Newcastle disease virus to enhance natural killer cell function against acute myeloid leukemia cells. Sci Rep. 2026; :. doi: 10.1038/s41598-026-56211-3. PubMed PMID:42270693 .
  15. Sekiya, I, Ozeki, N, Koga, H, Kurokouchi, K, Takahashi, S, Uchida, S et al.. Synovial mesenchymal stem cell-augmented meniscal repair for flap tears: A phase III multicenter clinical trial. J Orthop Sci. 2026; :. doi: 10.1016/j.jos.2026.05.011. PubMed PMID:42270542 .
  16. Torizal, FG, Tirtadani, Y, Gunady, AV, Mohamed, EMA, Angelius, C. Dialysis bioreactor enables high-density, serum-free expansion of dental pulp-derived mesenchymal stromal cells with enhanced secretome. Cytotherapy. 2026;28 (8):102820. doi: 10.1016/j.jcyt.2026.102820. PubMed PMID:42269277 .
  17. Zhang, L, Tang, K, Zhao, X, Du, Y. Enamel Matrix Derivative in Dental Pulp Regeneration: Biological Basis, Mechanistic Insights, and Translational Considerations. Stem Cells Int. 2026;2026 :5777572. doi: 10.1155/sci/5777572. PubMed PMID:42266834 PubMed Central PMC13243867.
  18. Rahimi, S, Khoshnazar, SM, Derakhshani, A, Shahrokhi, N. Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats. Animal Model Exp Med. 2026; :. doi: 10.1002/ame2.70207. PubMed PMID:42265831 .
  19. Ouyang, W, Rajan, SM, Xie, H, Yan, Z, Fawzy, A. Tideglusib-loaded hyaluronic acid hydrogels enhance odontogenic differentiation with adjunct low-intensity focused ultrasound. Dent Mater. 2026; :. doi: 10.1016/j.dental.2026.06.003. PubMed PMID:42264973 .
  20. Zhu, R, Zhang, Z, Zhu, J, Ren, Y, Pei, Y, Li, Y et al.. Comparative Analysis of a Novel Rat Bone Augmentation Model for Guided Bone Regeneration With Barrier Membranes. Clin Implant Dent Relat Res. 2026;28 (3):e70165. doi: 10.1111/cid.70165. PubMed PMID:42263778 .
  21. Shayya, G, Chassande, O, Kawtharany, L, Cretet-Rodeschini, C, Miyara, M, Raymond, AA et al.. Development of 3D in vitro mineralized bone model to reproduce dental implants osseointegration process. Biofabrication. 2026; :. doi: 10.1088/1758-5090/ae7b06. PubMed PMID:42263747 .
  22. Hlaing, KS, Shan, AP, Tamboon, E, Leelahavanichkul, A, Amornphimoltham, P. Rapamycin Targets Cancer Stem Cells to Decrease Cisplatin Resistance in a Head and Neck Cancer Mouse Xenograft Model. J Oral Pathol Med. 2026; :. doi: 10.1111/jop.70156. PubMed PMID:42261974 .
  23. Xing, Y, Su, J, Lin, Y, Huang, N, Zhang, S, Zhou, Y et al.. Senescent BMSC-Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin-Mediated Mitophagy in Macrophages. Aging Cell. 2026;25 (6):e70575. doi: 10.1111/acel.70575. PubMed PMID:42257494 PubMed Central PMC13244667.
  24. Jos Erry, HW, Margono, A, Bagio, DA, Suniarti, DF, Kusuma, I, Budi, HS et al.. Regenerative Potential of Exosomes from 3D Spheroid-Cultured Stem Cells Compared with 2D Culture in Dentin-Pulp Regeneration: A Systematic Review. Clin Cosmet Investig Dent. 2026;18 :614885. doi: 10.2147/CCIDE.S614885. PubMed PMID:42256838 PubMed Central PMC13242206.
  25. Chang, S, Anselmi, C, Mendes Soares, I, Cardoso, LM, Dos Reis-Prado, AH, de Carvalho, ABG et al.. Coaxial electrospinning of poly(ɛ-caprolactone)/gelatin core-shell biodegradable implants for localized delivery of metronidazole and dexamethasone for periodontal applications. Front Bioeng Biotechnol. 2026;14 :1770271. doi: 10.3389/fbioe.2026.1770271. PubMed PMID:42256719 PubMed Central PMC13237788.
  26. Chirico, M, Pisanu, ME, Mari, E, Manganelli, V, Pulcini, F, Lancia, L et al.. NMR metabolomics assessment of neural commitment of human dental pulp-derived stem cells. Front Mol Biosci. 2026;13 :1735166. doi: 10.3389/fmolb.2026.1735166. PubMed PMID:42256314 PubMed Central PMC13236527.
  27. Ahmad, P, Estrin, NE, Miron, RJ. Extracellular Vesicles in Regenerative Dentistry. J Dent Res. 2026; :220345261448514. doi: 10.1177/00220345261448514. PubMed PMID:42253004 .
  28. Yamashita, D, Shikano, Y, Hayashi, K, Saitou, M, Fujita, M, Irahara, M et al.. Changing Discourse on In Vitro Gametogenesis: Expectation, Scientific Reality, and the Ethics of Hype. Monash Bioeth Rev. 2026; :. doi: 10.1007/s40592-026-00295-0. PubMed PMID:42247096 .
  29. Sato, M, Saito, T, Komiya, Y, Noda, S, Tagawa, Y, Yamamoto, A et al.. Reciprocal Regulation of GLI1 and GLI3 Fine Tunes the Pathogenic Behavior of Synovial Fibroblasts in Rheumatoid Arthritis. Int J Rheum Dis. 2026;29 (6):e70690. doi: 10.1111/1756-185x.70690. PubMed PMID:42246142 PubMed Central PMC13238299.
  30. Mu, Q, Lu, H, Li, P, Wang, B, Lin, L, Chen, Y et al.. Extracellular vesicles derived from stem cells of human exfoliated deciduous teeth alleviate pulpitis through attenuation of mitochondrial dysfunction. Stem Cell Res Ther. 2026; :. doi: 10.1186/s13287-026-05078-2. PubMed PMID:42243964 .
  31. Salehi, MS, Ashjazadeh, N, Mohammadi, Y, Ghorbani, N, Ashayerizadeh, A, Jafarzadeh Shirazi, MR et al.. Comparative gene expression analysis of nestin-expressing hair follicle-derived cells. Sci Rep. 2026; :. doi: 10.1038/s41598-026-56299-7. PubMed PMID:42243416 .
  32. Zhang, T, Nagasawa, M, Koide, H, Kooanantkul, C, Nila, T, Uoshima, K et al.. Recruitment of Rat Bone Marrow-Derived Cells to Dental Implants Immediately After Installation. J Oral Implantol. 2026;52 (3):176-184. doi: 10.1563/aaid-joi-D-24-00234. PubMed PMID:42242694 .
  33. Carganico, A, Levrini, L, Zecca, PA, Mosca, A, Deppieri, A, Saran, S et al.. Biocompatibility of Orthodontic Aligner Materials in the Digital Workflow: A Quantitative In Vitro Comparison of Thermoformed, Directly Printed, and Polyamide-12 Systems. J Dent. 2026; :106812. doi: 10.1016/j.jdent.2026.106812. PubMed PMID:42242613 .
  34. Yang, F, Zhang, Z, Qiu, X, Lv, H. The Effect of miR-129-5p on the Proliferation and Osteogenic Differentiation of Human Dental Pulp Stem Cells. Int Dent J. 2026;76 (4):109653. doi: 10.1016/j.identj.2026.109653. PubMed PMID:42242011 .
  35. Ukon, Y, Hakui, H, Hosoya, S, Morita, K, Mae, H, Kanie, Y et al.. Unapproved regenerative medicine for spinal cord injury in Japan. Regen Ther. 2026;32 :101132. doi: 10.1016/j.reth.2026.101132. PubMed PMID:42238824 PubMed Central PMC13226842.
  36. Dam, B, Ajnabi, J, Saha, T, Shrivastava, A, Badarinathan, K, Hegde, A et al.. Mindin-mediated αM-integrin endocytosis activates STAT3 to maintain keratinocyte stemness. Cell Commun Signal. 2026; :. doi: 10.1186/s12964-026-02970-5. PubMed PMID:42237193 .
  37. Kutnyanszky, M, Stephens, P, Mead, B. Small extracellular vesicles promote cell survival and neuritogenesis in vitro in a manner dependent on dosage and cell of origin. Sci Rep. 2026; :. doi: 10.1038/s41598-026-53763-2. PubMed PMID:42236787 .
  38. Li, C, Zhang, Z, Yang, Z, Liu, T, He, X, Li, B et al.. OCT4-driven PER1 activation promotes odontogenic differentiation in senescent SCAP spheres. Int J Oral Sci. 2026;18 (1):. doi: 10.1038/s41368-026-00444-5. PubMed PMID:42236493 PubMed Central PMC13234415.
  39. Myint, YYK, Liu, A, Gao, J, Hatasa, M, Srithanyarat, SS, Iwata, T et al.. hsa-let-7c-3p Restrains the Proliferation-to-Osteogenesis Transition of Human Periodontal Ligament Mesenchymal Stem/Stromal Cells via NT5E. Stem Cell Rev Rep. 2026; :. doi: 10.1007/s12015-026-11160-2. PubMed PMID:42230452 .
  40. Sukarawan, W, Phothichailert, S, Kornsuthisopon, C, Rochanavibhata, S, Nantakeeratipat, T, Hiran-Us, S et al.. Latistat-2 modulates apoptosis and differentiation of human dental pulp stem cells. Odontology. 2026; :. doi: 10.1007/s10266-026-01438-9. PubMed PMID:42230423 .
  41. Abedanzadeh, M, Amiri, MA, Mohammadi, M, Ghatei, K, Daneshi, SS, Tanideh, N et al.. Photo-crosslinked methacrylated hyaluronic acid-iPRF hydrogel-based microneedles for accelerated wound repair. Int J Biol Macromol. 2026;370 :152846. doi: 10.1016/j.ijbiomac.2026.152846. PubMed PMID:42229655 .
  42. GBD 2023 Diarrhoeal Disease and Enteric Infectious Diseases Collaborators. Global burden of enteric infectious diseases, diarrhoeal diseases, and corresponding aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet Infect Dis. 2026; :. doi: 10.1016/S1473-3099(26)00194-5. PubMed PMID:42229499 .
  43. Li, H, Yu, N, Liu, H, Zhu, Z, Li, X, Si, C et al.. A Wet-and-Dry Research Model: Unveiling Biomechanics in Odontoblast Polarization. Int Endod J. 2026; :. doi: 10.1111/iej.70188. PubMed PMID:42227345 .
  44. Wang, H, Liu, J, Yang, X, Koohi-Moghadam, M, Gao, S, Han, Y et al.. Optimal Hypoxia Mimetic Small Molecules for Enhancing Angiogenic Properties of Stem Cells From Human Exfoliated Deciduous Teeth. Int Endod J. 2026; :. doi: 10.1111/iej.70191. PubMed PMID:42227314 .
  45. Wang, X, Liu, X, Wu, G, Wang, H, Yu, K, Liu, Y et al.. Development of a novel GAK solution for efficient hypothermic preservation of NK cell viability and anti-tumor function. Stem Cell Res Ther. 2026; :. doi: 10.1186/s13287-026-05083-5. PubMed PMID:42226278 .
  46. Bojnordi, MN, Hamidabadi, HG, Bagheri-Mohammadi, S, Saeednia, S, Kazemi, K. Clay/chitosan/poly(vinyl alcohol) nanofiber scaffold promotes differentiation of human dental pulp stem cells toward cholinergic and motor neuron subtypes. Cell Tissue Bank. 2026;27 (3):. doi: 10.1007/s10561-026-10225-3. PubMed PMID:42223721 .
  47. Bosso, M, Moraes, ÂM. Characterization of Thermoresponsive Methylcellulose-Based Injectable Hydrogels Incorporating 58S Bioactive Glass for Non-Load-Bearing Bone Regeneration. ACS Omega. 2026;11 (20):29843-29857. doi: 10.1021/acsomega.6c00586. PubMed PMID:42222794 PubMed Central PMC13216992.
  48. Ahmad, A. Plasticity in Cancer Cells: The Master Engine of Therapeutic Resistance and Tumor Evolution. Curr Mol Med. 2026; :. doi: 10.2174/0115665240472692260521045539. PubMed PMID:42220158 .
  49. Ahmad, P, Sculean, A, Miron, RJ. Understanding exosomes in regenerative dentistry. Periodontol 2000. 2026; :. doi: 10.1111/prd.70054. PubMed PMID:42220016 .
  50. Kimura, M, Okita, Y, Iwabuchi, E, Hong, X, Ichikawa, Y, Elhinnawi, MA et al.. Effect of the Mutual Interaction of GPNMB and LPAR1 on Cellular Motility and Tumorigenicity in Mammary Epithelial Cells. Pathol Int. 2026;76 (6):e70134. doi: 10.1111/pin.70134. PubMed PMID:42219803 .
  51. Hortu, I, Kandemir Demirci, G, Şimşek, B, Eroğlu, E, Germiyan, ÖS, Gökhan, A et al.. Dental pulp-derived mesenchymal stem cells reduce lesion progression in a rat model of endometriosis. Sci Rep. 2026; :. doi: 10.1038/s41598-026-52416-8. PubMed PMID:42218212 .
  52. Li, T, Shen, Z, Liu, J, Zhang, Z, Ren, H, Chen, L et al.. PIEZO1 mediates orthodontic tension force-induced alveolar bone remodeling via the Ca²⁺/YAP-TAZ pathway in periodontal ligament stem cells. J Transl Med. 2026; :. doi: 10.1186/s12967-026-08330-8. PubMed PMID:42216208 .
  53. Shidara, S, Desai, KM, Mizoguchi, T. LepR+ skeletal stem/progenitor cells in craniofacial tissues. J Oral Biosci. 2026;68 (4):100791. doi: 10.1016/j.job.2026.100791. PubMed PMID:42215009 .
  54. Vatanpour, M, Hashemi, J, Toursavadkouhi, S, Barikrou, N, Kaghazloo, P. Effect of low-level laser on adhesion of undifferentiated mesenchymal stem cells to human dentin: An ex-vivo study. Photodiagnosis Photodyn Ther. 2026; :105529. doi: 10.1016/j.pdpdt.2026.105529. PubMed PMID:42214732 .
  55. Benton Swanson, W, Douglas, L, Woodbury, SM, Albright, J, Pan, H, Omi-Sugihara, M et al.. A tissue engineering approach to regenerate the cranial suture skeletal stem cell niche with a multicompartment biomaterial scaffold. Bone Res. 2026;14 (1):. doi: 10.1038/s41413-026-00539-z. PubMed PMID:42209469 PubMed Central PMC13219457.
  56. Juman, O, Leite, ML. Inflammatory Modulation and Odontogenic Responses of Riboflavin-loaded Hydrogel Applied for Regenerative Endodontics. J Endod. 2026; :. doi: 10.1016/j.joen.2026.05.008. PubMed PMID:42208760 .
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  58. Qiao, X, Liu, K, Tang, J, Du, J, Sun, Q, Deng, S et al.. A multifunctional nanotherapeutic strategy based on exosome-liposome hybrid nanoparticles for comprehensive periodontitis management. J Nanobiotechnology. 2026; :. doi: 10.1186/s12951-026-04602-z. PubMed PMID:42204732 .
  59. Bojnordi, MN, Bagheri-Mohammadi, S, Hamidabadi, HG. Preconditioning of human dental pulp stem cells by H2O2 promote functional recovery in a rat spinal cord contusion injury model. Anat Cell Biol. 2026; :. doi: 10.5115/acb.25.066. PubMed PMID:42203667 .
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