Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Shen, Y, Wang, L, Guo, Z, Wang, J, Zhang, R, Tang, C et al.. METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs. Cell Signal. 2025; :111873. doi: 10.1016/j.cellsig.2025.111873. PubMed PMID:40381973 .
  2. Nan, DN, Praneetpong, N, Bulanawichit, W, Chantarangsu, S, Everts, V, Ferreira, JN et al.. Biomechanical force-primed periodontal ligament stem cells exhibit a tolerance effect against bacterial inflammation. J Dent. 2025; :105820. doi: 10.1016/j.jdent.2025.105820. PubMed PMID:40381879 .
  3. He, F, Zhu, J, Zeng, X, Jiang, L, Zhang, L. Effects of Porphyromonas gingivalis lipopolysaccharide on the behavior of human dental pulp stem cells in vitro and their inflammation-related transcriptomics profile. Arch Oral Biol. 2025;176 :106295. doi: 10.1016/j.archoralbio.2025.106295. PubMed PMID:40381466 .
  4. Zhang, XH, He, YD, Wang, H, Cao, Y, Ying, SQ, Liu, JN et al.. Development-Inspired Biomimetic Cell-Niche Coaggregates Safeguard Tooth Stem Cell-Based Functional Tissue Regeneration. Adv Healthc Mater. 2025; :e2501550. doi: 10.1002/adhm.202501550. PubMed PMID:40376872 .
  5. Wang, Y, Tu, M, Gao, H, Deng, S. Impacts of Circular RNAs on the Osteogenic Differentiation of Dental Stem Cells. Stem Cells Int. 2025;2025 :8338337. doi: 10.1155/sci/8338337. PubMed PMID:40376229 PubMed Central PMC12081154.
  6. Assoratgoon, I, Nowwarote, N, Phothichailert, S, Dissanayaka, WL, Samaranayake, LP, Osathanon, T et al.. Unravelling the role of interleukin-6 in regulating dental stem cell behaviour: a scoping review. BMC Oral Health. 2025;25 (1):732. doi: 10.1186/s12903-025-06097-w. PubMed PMID:40375224 PubMed Central PMC12082909.
  7. Ubara, Y, Kono, K, Hoshino, J, Wada, T, Wake, A, Ohashi, K et al.. Trend of treatment strategy for amyloid light-chain amyloidosis: a-single center experience. Clin Exp Nephrol. 2025; :. doi: 10.1007/s10157-025-02696-7. PubMed PMID:40372551 .
  8. Dallos Ortega, M, Aveyard, J, Magdy Abdelgawad, R, El-Gendy, R, Ciupa, A, Whetnall, D et al.. Antimicrobial 3D printed gelatin scaffolds for root canal disinfection in regenerative endodontics procedures. Biomater Sci. 2025; :. doi: 10.1039/d5bm00440c. PubMed PMID:40372258 .
  9. Dadhich, P, Pal, P, Dogra, N, Srivas, PK, Das, B, Das, S et al.. Calcium Phosphate Apatite Filament Co-Wrapped With Perforated Electrospun Sheet of Phosphorylated Chitosan-A Bioinspired Approach Toward Bone Graft Substitute. J Biomed Mater Res B Appl Biomater. 2025;113 (5):e35589. doi: 10.1002/jbm.b.35589. PubMed PMID:40371991 .
  10. Li, L, Wu, J, Liu, L, Zhang, P, Zhang, Y, Zhou, Z et al.. Photothermal Antibacterial Effect of Gold Nanostars Coating on Titanium Implant and Its Osteogenic Performance. Int J Nanomedicine. 2025;20 :5983-5999. doi: 10.2147/IJN.S519183. PubMed PMID:40370805 PubMed Central PMC12075448.
  11. Cheng, D, Yuan, X, Ma, Z, Lin, X, Zhu, Z, Wang, J et al.. Canonical Wnt Pathway Enhanced Dental Pulp Mesenchymal Stem Cells-Mediated Cementum Regeneration. J Oral Rehabil. 2025; :. doi: 10.1111/joor.14001. PubMed PMID:40369784 .
  12. Dong, R, Li, M, Gu, XF, Gao, H, Wei, Z, Qi, H et al.. The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2. J Transl Med. 2025;23 (1):540. doi: 10.1186/s12967-025-06569-1. PubMed PMID:40369630 PubMed Central PMC12080044.
  13. Shimizu, T, Miyoshi, M, Kakinuma, S, Tsuchiya, J, Yamane, D, Watakabe, K et al.. Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids. Cell Rep. 2025; :115675. doi: 10.1016/j.celrep.2025.115675. PubMed PMID:40367952 .
  14. Zamorano, M, Aguilar-Gallardo, C, Lugo, A, Jimenez, L, Farias, JG, Mantalaris, A et al.. Engineering an Integrated Bioprocess to Produce Human Dental Pulp Stem Cell-Alginate-Based Bone Organoids. Int J Mol Sci. 2025;26 (9):. doi: 10.3390/ijms26094348. PubMed PMID:40362585 PubMed Central PMC12073084.
  15. Ni, Z, Cai, L, Tsai, IC, Ding, W, Tian, C, Li, D et al.. NAT10 Regulates LPS-Induced Inflammation via Stabilization of N4-Acetylated PTX3 mRNA in Human Dental Pulp Stem Cells. Int J Mol Sci. 2025;26 (9):. doi: 10.3390/ijms26094325. PubMed PMID:40362562 PubMed Central PMC12072506.
  16. Liu, J, Chen, Y, Li, Z, Li, Z, Lyu, F, Wang, F et al.. Human dental pulp stem cells attenuate airway inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting the pyroptosis pathway. Stem Cell Res Ther. 2025;16 (1):240. doi: 10.1186/s13287-025-04368-5. PubMed PMID:40361181 PubMed Central PMC12076901.
  17. Park, S, Kim, JE, Lee, J, Kim, W, Choi, W, Lee, MC et al.. Bioimplant-on-a-Chip for Facile Investigation of Periodontal Ligament Formation on Biogenic Hydroxyapatite/Ti6Al4 V Implants. ACS Appl Mater Interfaces. 2025; :. doi: 10.1021/acsami.5c04687. PubMed PMID:40359253 .
  18. Atia, GA, Abdal Dayem, A, Taher, ES, Alghonemy, WY, Cho, SG, Aldarmahi, AA et al.. Urine-derived stem cells: a sustainable resource for advancing personalized medicine and dental regeneration. Front Bioeng Biotechnol. 2025;13 :1571066. doi: 10.3389/fbioe.2025.1571066. PubMed PMID:40357329 PubMed Central PMC12066649.
  19. Zhang, Q, Cao, S, Zhang, M, Wu, D, Zhang, C, Li, J et al.. Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway. Int Dent J. 2025;75 (4):100819. doi: 10.1016/j.identj.2025.03.028. PubMed PMID:40354696 .
  20. Brümmer, N, Doll-Nikutta, K, Schadzek, P, Mikolai, C, Kampmann, A, Wirth, D et al.. Better models, better treatment? a systematic review of current three dimensional (3D) in vitro models for implant-associated infections. Front Bioeng Biotechnol. 2025;13 :1569211. doi: 10.3389/fbioe.2025.1569211. PubMed PMID:40352353 PubMed Central PMC12061920.
  21. Maleki, L, Fattahi, B, Razavi, SM, Shekarian, M, Eskandari, S. CD44 and EPCAM expression in pleomorphic adenoma and mucoepidermoid carcinoma: An immunohistochemical method. Dent Res J (Isfahan). 2025;22 :16. doi: 10.4103/drj.drj_545_24. PubMed PMID:40351859 PubMed Central PMC12063989.
  22. Ma, Y, Ghosh, S, Kong, X, Kalimuthu, S, Pudipeddi, A, Okuro, K et al.. Nanoscale bismuth infused bioadhesive gelatin methacryloyl electrospun mats demonstrate excellent antibiofilm activity and biocompatibility. Int J Biol Macromol. 2025;312 :144103. doi: 10.1016/j.ijbiomac.2025.144103. PubMed PMID:40350112 .
  23. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Glucagon-Like Peptide 1 Receptor Agonists (GLP-1RAs) Improve Periodontal and Peri-Implant Health in Type 2 Diabetes Mellitus. J Periodontal Res. 2025; :. doi: 10.1111/jre.13410. PubMed PMID:40348599 .
  24. Pilbauerova, N, Dasi, D, De Souza Araujo, IJ, Huang, GT. An in vitro tube model for cell biocompatibility study of capping materials for regenerative endodontics. J Endod. 2025; :. doi: 10.1016/j.joen.2025.04.018. PubMed PMID:40348362 .
  25. Sedek, EM, Holiel, AA. Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges. Tissue Eng Regen Med. 2025; :. doi: 10.1007/s13770-025-00725-w. PubMed PMID:40347432 .
  26. Garcia-de-Albeniz, N, Müller, DW, Mücklich, F, Ginebra, MP, Jiménez-Piqué, E, Mas-Moruno, C et al.. Tailoring Cell Behavior and Antibacterial Properties on Zirconia Biomaterials through Femtosecond Laser-Induced Micropatterns and Nanotopography. ACS Appl Mater Interfaces. 2025; :. doi: 10.1021/acsami.4c22433. PubMed PMID:40347147 .
  27. Gu, X, Wei, W, Wu, C, Sun, J, Wu, X, Shen, Z et al.. Profiling and functional characterization of long noncoding RNAs during human tooth development. Int J Oral Sci. 2025;17 (1):38. doi: 10.1038/s41368-025-00375-7. PubMed PMID:40346090 PubMed Central PMC12064826.
  28. Saito, R, Hasebe, M, Hara, T, Tanegashima, K. Expression cloning of cell surface receptors for the CpG oligodeoxynucleotide/CXCL14 complex. Biochem Biophys Res Commun. 2025;768 :151954. doi: 10.1016/j.bbrc.2025.151954. PubMed PMID:40345012 .
  29. Zhang, Y, Zhang, Y, Chen, Y, Wu, W, Sun, J, Zhang, X et al.. Impact of intercellular adhesion molecule 1-positive dental pulp stem cells in deep caries progression. Int Endod J. 2025; :. doi: 10.1111/iej.14248. PubMed PMID:40343788 .
  30. Jiang, W, Duan, S, Li, W, Yan, H, Si, C, Xu, N et al.. PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration. Front Bioeng Biotechnol. 2025;13 :1578410. doi: 10.3389/fbioe.2025.1578410. PubMed PMID:40343206 PubMed Central PMC12058851.
  31. Song, GJ, Oh, SH, Lee, JH, Lee, M, Hwang, HS, Koh, JT et al.. Photo-curable layered double hydroxide-hyaluronic acid-composite hydrogels with multifunctional properties for growth factor-free bone regeneration. Int J Biol Macromol. 2025; :143980. doi: 10.1016/j.ijbiomac.2025.143980. PubMed PMID:40339864 .
  32. Recka, N, Simons, A, Cornell, RA, Van Otterloo, E. Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification. J Invest Dermatol. 2025; :. doi: 10.1016/j.jid.2025.04.008. PubMed PMID:40339790 .
  33. Behzadi, P, Wendling, AA, Cuevas, RA, Crane, A, Chu, CC, Moorhead, WJ 3rd et al.. Rapamycin Reduces Arterial Mineral Density and Promotes Beneficial Vascular Remodeling in a Murine Model of Severe Medial Arterial Calcification. Am J Physiol Heart Circ Physiol. 2025; :. doi: 10.1152/ajpheart.00530.2024. PubMed PMID:40338175 .
  34. Rossi, A, Ferrari, G, Galli, V, Bonacini, M, Carnevale, G, Pisciotta, A et al.. Immunomodulatory effects of dental pulp stem cells on lymphocytes and monocytes from patients with rheumatoid arthritis. Clin Exp Rheumatol. 2025;43 (5):809-814. doi: 10.55563/clinexprheumatol/l64k20. PubMed PMID:40338061 .
  35. Yang, S, Liu, J, Khe, JS, Lu, AJH, Lim, V. Emerging insights into mesenchymal stem cells and exosome-based therapies for liver injury. Biomol Biomed. 2025; :. doi: 10.17305/bb.2025.12144. PubMed PMID:40338014 .
  36. Aga, N, McGregor, S, Jones, S, Ellis, I, Tatullo, M, Hassan, MEM et al.. EFFICACY OF STEM CELLS IN ENDODONTIC REGENERATION: A SYSTEMATIC REVIEW. J Evid Based Dent Pract. 2025;25 (2):102125. doi: 10.1016/j.jebdp.2025.102125. PubMed PMID:40335194 .
  37. Cecilia, PH, Narmada, IB, Ridwan, RD, Ernawati, DS, Bramantoro, T, Rianti, D et al.. Adipose-Derived Mesenchymal Stem Cell Osteodifferentiation after Exposure to Beta-Tricalcium Phosphate Bioceramic Granules with 300 to 600 and 600 to 1,000 µm Sizes. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1806964. PubMed PMID:40334681 .
  38. Aliaga-Gálvez, R, Gutiérrez, MF, Valenzuela, B, Geraldeli, S, Abuna, G, Inostroza, C et al.. The Incorporation of Copper-Doped Bioactive Glass Nanoparticles into Resin Composites Improves Their Biological, Mechanical and Adhesive Properties. J Adhes Dent. 2025;27 :103-114. doi: 10.3290/j.jad.c_2014. PubMed PMID:40331405 PubMed Central PMC12057575.
  39. Wang, Y, Fang, C, Mao, LB, Feng, YH, Meng, YF, Wang, HC et al.. A novel Liesegang-patterned mineralized hydrogel drives bone regeneration with microstructure control. Mater Today Bio. 2025;32 :101775. doi: 10.1016/j.mtbio.2025.101775. PubMed PMID:40331154 PubMed Central PMC12053635.
  40. Tajpara, P, Sobkowiak, MJ, Healy, K, Naud, S, Gündel, B, Halimi, A et al.. Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids. Front Immunol. 2025;16 :1553034. doi: 10.3389/fimmu.2025.1553034. PubMed PMID:40330456 PubMed Central PMC12053177.
  41. Parisay, I, Moodi, M, Boskabady, M, Bagheri, H, Salari, R, Hoseinzadeh, M et al.. Physical and drug- releasing properties of a cement containing simvastatin (SimCeram). BMC Oral Health. 2025;25 (1):684. doi: 10.1186/s12903-025-06045-8. PubMed PMID:40325441 PubMed Central PMC12051323.
  42. Jeon, HH, Salas, MCC, Park, K, Fisher, L, Ha, S, Palmer, C et al.. Comparison of the bone remodeling in the midpalatal suture during maxillary expansion between young and middle-aged mice. Bone. 2025;197 :117512. doi: 10.1016/j.bone.2025.117512. PubMed PMID:40324615 .
  43. Tomalka, JA, Owings, A, Galeas-Pena, M, Ziegler, CGK, Robinson, TO, Wichman, TG et al.. Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection. FASEB J. 2025;39 (9):e70600. doi: 10.1096/fj.202403195R. PubMed PMID:40322970 .
  44. Shen, D, Li, Y, Shi, J, Zhang, T, Nie, JJ, Chen, D et al.. Biodegradable Zn-Li-Mn alloy to achieve optimal strength and ductility for bone implants. Acta Biomater. 2025; :. doi: 10.1016/j.actbio.2025.04.056. PubMed PMID:40318745 .
  45. Hu, Y, Wang, Y, Liu, Y, Dai, J, Wang, J, Ju, C et al.. Injectable laponite nanocomposite hydrogel with synergistic antibacterial and odontogenic activity for endodontic regeneration. Colloids Surf B Biointerfaces. 2025;253 :114745. doi: 10.1016/j.colsurfb.2025.114745. PubMed PMID:40318397 .
  46. Khaseb, S, Kohansal Vajari, M, Soufi Zomorrod, M, Rezai Rad, M, Ajami, M, Ajami, M et al.. Effect of fibrin on the expression of adhesion molecules (ICAM-1, ITGAV, and ITGB3) in unrestricted somatic stem cells. Hematol Transfus Cell Ther. 2025;47 (2):103827. doi: 10.1016/j.htct.2025.103827. PubMed PMID:40315755 .
  47. Ding, R, Chen, C, Wang, L, Wang, Y, Chai, Z, He, S et al.. Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation. Int Dent J. 2025;75 (4):100783. doi: 10.1016/j.identj.2025.02.022. PubMed PMID:40315698 .
  48. Hu, Y, Huang, G, Dai, Z, Yang, R, Zhang, Y, Zhang, Y et al.. Artificial Cell-Derived Vesicles: Extracellular Vesicle Mimetics for Chondrocyte Restoration in TMJOA Therapy. Int J Nanomedicine. 2025;20 :5393-5405. doi: 10.2147/IJN.S508449. PubMed PMID:40313864 PubMed Central PMC12044611.
  49. Margono, A, Pratiwi, RS, Nofarina, AD, Npa, DA, Maharti, ID, Rosseti, R et al.. Biocompatibility and Bioactivity Evaluation of Novel Calcium Silicate-Based Sealer: In Vitro Study on Human Dental Pulp Stem Cells. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1802566. PubMed PMID:40311629 .
  50. Al Shehadat, S, Rani, A, Shehadat, OA, Abou Neel, EA, Yadadi, SS, Al-Rawi, N et al.. Investigating the Effects of Bead Formation on the Physicochemical and Biological Properties of Electrospun Poly(lactic-co-glycolic Acid) (PLGA) Membranes: A Comparative Analysis. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1804885. PubMed PMID:40311626 .
  51. Sharma, R, Holtzman, NG, Pusic, I, Cutler, CS, Treister, N, Mehta, RS et al.. Belumosudil reduces oral chronic graft-versus-host disease tissue inflammation and fibrosis: a ROCKstar companion study. Blood Adv. 2025; :. doi: 10.1182/bloodadvances.2025016170. PubMed PMID:40311075 .
  52. Li, Y, Jiang, B, Wu, Z, Ma, Z, Qiu, L, Cui, W et al.. Engineering fibroblast with reprogramming and spheronization for bone defect repair. Bioact Mater. 2025;50 :414-431. doi: 10.1016/j.bioactmat.2025.04.021. PubMed PMID:40309255 PubMed Central PMC12041790.
  53. Iwasaki, A, Hatakeyama, M, Liu, Q, Orimoto, A, Fukuda, T, Kitaoka, T et al.. Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds. Carbohydr Polym. 2025;359 :123593. doi: 10.1016/j.carbpol.2025.123593. PubMed PMID:40306767 .
  54. Umapathy, VR, Natarajan, PM, Swamikannu, B. Regenerative Strategies in Dentistry: Harnessing Stem Cells, Biomaterials and Bioactive Materials for Tissue Repair. Biomolecules. 2025;15 (4):. doi: 10.3390/biom15040546. PubMed PMID:40305324 PubMed Central PMC12025071.
  55. Janbaz, P, Behzadpour, F, Ghanadan, K. Evaluation of the Structural, Biological, and Bone Induction Properties of Sol-Gel-Derived Lithium-Doped 68S Bioactive Glass-An in Vitro Study on Human Dental Pulp Stem Cells. Clin Exp Dent Res. 2025;11 (3):e70139. doi: 10.1002/cre2.70139. PubMed PMID:40304308 PubMed Central PMC12042117.
  56. Surisaeng, T, Wisitrasameewong, W, Champaiboon, C, Sa-Ard-Iam, N, Chanamuangkon, T, Thongnuek, P et al.. BMP-2 mRNA-transfected BMSCs promote superior calvarial bone regeneration. Sci Rep. 2025;15 (1):15022. doi: 10.1038/s41598-025-99979-6. PubMed PMID:40301548 PubMed Central PMC12041208.
  57. Mante, N, Undale, V, Sanap, A, Bhonde, R, Tambe, P, Bansode, M et al.. Disease microenvironment preconditioning: An evolving approach to improve therapeutic efficacy of human mesenchymal stromal cells. Int Immunopharmacol. 2025;157 :114701. doi: 10.1016/j.intimp.2025.114701. PubMed PMID:40300358 .
  58. Wen, C, Chen, X, Lai, L. Identifying metabolic biomarkers and pathways in pulpitis: a metabolomic study using ultra-high-performance liquid chromatography/orbitrap mass spectrometry. J Appl Oral Sci. 2025;33 :e20240428. doi: 10.1590/1678-7757-2024-0428. PubMed PMID:40298663 PubMed Central PMC12061451.
  59. Gultekin, SE, Arslan Bozdag, L, Odenthal, M, Dienes, HP. Epigenetic Regulation of Dental Follicle Stem Cells in Odontogenic Regeneration. J Cell Mol Med. 2025;29 (9):e70541. doi: 10.1111/jcmm.70541. PubMed PMID:40296331 PubMed Central PMC12037698.
  60. Sleep, SL, Ranjit, E, Gunter, J, Hryciw, DH, Arany, P, George, R et al.. Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study. J Biophotonics. 2025; :e70051. doi: 10.1002/jbio.70051. PubMed PMID:40294940 .
  61. Naidu, P, Das, M, Hansda, S, Prateeksha, P, Howlader, MSI, Siraj, MA et al.. Mechanisms of Ellagic Acid (EA)-Mediated Osteogenic Differentiation of Human Dental Pulp-Derived Stem Cells. ACS Omega. 2025;10 (15):15229-15242. doi: 10.1021/acsomega.4c10642. PubMed PMID:40290905 PubMed Central PMC12019503.
  62. Ma, S, Yao, S, Li, Y, Yang, Y, Tong, T, Zheng, H et al.. A pH-Responsive Polyetheretherketone Implant Modified with a Core-Shell Metal-Organic Framework to Promote Antibacterial and Osseointegration Abilities. Biomater Res. 2025;29 :0188. doi: 10.34133/bmr.0188. PubMed PMID:40290761 PubMed Central PMC12022397.
  63. Anselmi, C, Mendes Soares, IP, Chang, S, Cardoso, LM, de Carvalho, ABG, Dal-Fabbro, R et al.. Quercetin-calcium hydroxide scaffolds modulate dental pulp stem cell response in vitro under a simulated inflammatory environment. Int Endod J. 2025; :. doi: 10.1111/iej.14243. PubMed PMID:40285990 .
  64. Garg, N, Krishna, R, Urs, AB, Kumar, P, Augustine, J. A systematic review on the molecular pathways of Ameloblastic carcinoma when compared to Ameloblastoma. Expert Rev Mol Diagn. 2025; :1-13. doi: 10.1080/14737159.2025.2499180. PubMed PMID:40285826 .
  65. Paraš, S, Petrović, B, Mitić, D, Lazarević, M, Popović Bajić, M, Živković, M et al.. Three-Dimensional-Printed Bone Grafts for Simultaneous Bone and Cartilage Regeneration: A Promising Approach to Osteochondral Tissue Engineering. Pharmaceutics. 2025;17 (4):. doi: 10.3390/pharmaceutics17040489. PubMed PMID:40284484 PubMed Central PMC12030389.
  66. Sillmann, YM, Eber, P, Orbeta, E, Wilde, F, Gross, AJ, Guastaldi, FPS et al.. Milestones in Mandibular Bone Tissue Engineering: A Systematic Review of Large Animal Models and Critical-Sized Defects. J Clin Med. 2025;14 (8):. doi: 10.3390/jcm14082717. PubMed PMID:40283548 PubMed Central PMC12027812.
  67. Zhu, Y, Ge, X, Chen, Z, Chen, T, Wu, Y, Wen, H et al.. METTL3-m6A methylase regulates the osteo-/odontogenic potential of stem cells from apical papilla via NFIC in apical periodontitis. Exp Cell Res. 2025;448 (2):114576. doi: 10.1016/j.yexcr.2025.114576. PubMed PMID:40280320 .
  68. Boisen, IM, Krarup Knudsen, N, Nielsen, JE, Kooij, I, Bagger, ML, Kaludjerovic, J et al.. Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications. Elife. 2025;13 :. doi: 10.7554/eLife.95545. PubMed PMID:40279260 PubMed Central PMC12029210.
  69. Stieger, RB, Lilaj, B, Hönigl, GP, Pock, S, Cvikl, B. Flow Cytometry Illuminates Dental Stem Cells: a Systematic Review of Immunomodulatory and Regenerative Breakthroughs. Stem Cell Rev Rep. 2025; :. doi: 10.1007/s12015-025-10883-y. PubMed PMID:40279028 .
  70. Zhao, HR, Zhao, JZ, Zhao, N, Xue, LF, Xu, YX, Yue, J et al.. CA1 induced dental follicle stem cells co-culture with dental pulp stem cells and loaded three-dimensional printed PCL/β-TCP scaffold: a novel strategy for alveolar cleft bone regeneration. J Mater Sci Mater Med. 2025;36 (1):37. doi: 10.1007/s10856-025-06889-0. PubMed PMID:40278949 PubMed Central PMC12031973.
  71. Seciu-Grama, AM, Lazăr, SE, Petrescu, S, Mocioiu, OC, Crăciunescu, O, Atkinson, I et al.. Impact of Vitamin D3 Functionalization on the Osteogenic Capacity of Bioinspired 3D Scaffolds Based on Ce-Doped Bioactive Glass and Spongia Agaricina. J Funct Biomater. 2025;16 (4):. doi: 10.3390/jfb16040141. PubMed PMID:40278249 PubMed Central PMC12027579.
  72. Mitic, DD, Milosevic Markovic, MS, Jovanovic, ID, Mancic, DD, Orhan, K, Jokanovic, VR et al.. A Biomimetic Approach to Diode Laser Use in Endodontic Treatment of Immature Teeth: Thermal, Structural, and Biological Analysis. Biomimetics (Basel). 2025;10 (4):. doi: 10.3390/biomimetics10040216. PubMed PMID:40277616 PubMed Central PMC12025333.
  73. Kim, H, Williams, SJ, Colombo, JS. Characterization of Fibronectin-Adherent, Non-Fibronectin-Adherent, and Explant-Derived Human Dental Pulp Stem Cell Populations. Dent J (Basel). 2025;13 (4):. doi: 10.3390/dj13040159. PubMed PMID:40277489 PubMed Central PMC12026221.
  74. Yu, L, Yang, F, Li, C, Ruan, J, Wang, J. Poly(amidoamine) Dendrimers as Potential Therapeutic Agents for Conservative Treatment of Irreversible Pulpitis. J Endod. 2025; :. doi: 10.1016/j.joen.2025.04.007. PubMed PMID:40274259 .
  75. Zhang, Q, Yi, Y, Chen, T, Ai, Y, Chen, Z, Liu, G et al.. M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis. J Nanobiotechnology. 2025;23 (1):311. doi: 10.1186/s12951-025-03390-2. PubMed PMID:40270025 PubMed Central PMC12020034.
  76. Budi, HS, Handajani, J, Amir, LR, Soekanto, SA, Ulfa, NM, Wulansari, SA et al.. Nanoemulgel Development of Stem Cells from Human Exfoliated Deciduous Teeth-Derived Conditioned Medium as a Novel Nanocarrier Growth Factors. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1806963. PubMed PMID:40267955 .
  77. Belludi, SA, Shaik, S, Pradhan, N, Rema, S. Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report. J Adv Periodontol Implant Dent. 2025;17 (1):54-58. doi: 10.34172/japid.025.3502. PubMed PMID:40265038 PubMed Central PMC12010481.
  78. Hu, M, Wu, L, Wei, E, Pan, X, Zhu, Q, Xiuyun, X et al.. Sildenafil promotes osteogenic differentiation of human mesenchymal stem cells and inhibits bone loss by affecting the TGF-β signaling pathway. Stem Cell Res Ther. 2025;16 (1):201. doi: 10.1186/s13287-025-04320-7. PubMed PMID:40264229 PubMed Central PMC12016470.
  79. Hammad, M, Dugué, J, Maubert, E, Baugé, C, Boumédiene, K. Decellularized apple hypanthium as a plant-based biomaterial for cartilage regeneration in vitro: a comparative study of progenitor cell types and environmental conditions. J Biol Eng. 2025;19 (1):38. doi: 10.1186/s13036-025-00502-2. PubMed PMID:40264116 PubMed Central PMC12012941.
  80. Wang, L, Liu, T, Zhang, W, Liu, H, Qi, Y, Li, M et al.. BMAL1-downregulation drives PANoptosis and the osteogenic differentiation impairment of PDLSCs by ERK/AP-1 signaling pathway. J Periodontol. 2025; :. doi: 10.1002/JPER.24-0497. PubMed PMID:40259757 .
  81. Acharya, JR, Kumar, S, Girdhar, GA, Patel, S, Parekh, NH, Patadiya, HH et al.. 3D Bioprinting: Shaping the Future of Periodontal Tissue Regeneration and Disease Management. Cureus. 2025;17 (4):e82432. doi: 10.7759/cureus.82432. PubMed PMID:40255528 PubMed Central PMC12007905.
  82. Al Hamwi, G, Alnouri, MW, Verdonck, S, Leonczak, P, Chaki, S, Frischbutter, S et al.. Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models. Signal Transduct Target Ther. 2025;10 (1):128. doi: 10.1038/s41392-025-02209-8. PubMed PMID:40254631 PubMed Central PMC12010006.
  83. Ku, D, Yang, Y, Park, Y, Jang, D, Lee, N, Lee, YK et al.. SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases. Cell Rep. 2025;44 (5):115588. doi: 10.1016/j.celrep.2025.115588. PubMed PMID:40253699 .
  84. Takahara, S, Ohkura, N, Yoshiba, N, Baldeon-Gutierrez, R, Gomez-Kasimoto, S, Edanami, N et al.. Influence of Tooth Maturity on Healing Outcomes in Regenerative Endodontics. J Dent Res. 2025; :220345251325826. doi: 10.1177/00220345251325826. PubMed PMID:40251757 .
  85. Karimi, M, Sheibani Pour, M, Etemadi, A, Karimi, MA, Hodjat, M, Chiniforush, N et al.. The photobiomodulation effects of continuous and pulsed blue diode laser on proliferation and osteogenic differentiation of periodontal ligament stem cells. Photochem Photobiol. 2025; :. doi: 10.1111/php.14104. PubMed PMID:40251753 .
  86. Ding, Y, Ran, Y. OGA promotes human dental pulp stem cell senescence and inhibits mitophagy by inhibition of O-GlcNAcylation of KLF2. BMC Oral Health. 2025;25 (1):595. doi: 10.1186/s12903-025-05927-1. PubMed PMID:40251583 PubMed Central PMC12008942.
  87. Raik, S, Kaur, B, Kumar, S, Rattan, V, Kumar, N, Bhattacharyya, S et al.. Secretome Derived From Mesenchymal Stem Cells Cultured as Monolayer Show Enhanced Bone Regeneration Compared to Secretome From 3D Spheroid - Clues From the Proteome. Adv Healthc Mater. 2025; :e2500885. doi: 10.1002/adhm.202500885. PubMed PMID:40249147 .
  88. Liu, Y, Peng, Y, Chen, L, Xiang, Y, Zhang, X, Song, J et al.. Single-cell sequencing systematically analyzed the mechanism of Emdogain on the restoration of delayed replantation periodontal membrane. Int J Oral Sci. 2025;17 (1):33. doi: 10.1038/s41368-024-00345-5. PubMed PMID:40246878 PubMed Central PMC12006293.
  89. Wang, X, Wang, L, Zhou, L, Chen, L, Shi, J, Ge, J et al.. NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming. Int J Oral Sci. 2025;17 (1):34. doi: 10.1038/s41368-025-00362-y. PubMed PMID:40246825 PubMed Central PMC12006529.
  90. Soe, ZC, Nan, DN, Wahyudi, R, Vongsutilers, V, Kamolratanakul, P, Everts, V et al.. Asiaticoside-Loaded Nanosponges Hydrogel Has an Anti-inflammatory Effect and Promotes Human Dental Pulp Regeneration. J Endod. 2025; :. doi: 10.1016/j.joen.2025.04.004. PubMed PMID:40246141 .
  91. Hajialigol, A, Azizi, G, Seifi Alan, M, Soltani, A, Arabian, Z, Tamiji, M et al.. Dominant-Negative Versus Gain-of-Function STAT3 Defects: A Systematic Review on Epidemiological, Clinical, Immunological, and Molecular Aspects. J Allergy Clin Immunol Pract. 2025; :. doi: 10.1016/j.jaip.2025.04.014. PubMed PMID:40246075 .
  92. Fernández-Pérez, AG, Herrera-González, A, López-Naranjo, EJ, Martínez-Álvarez, IA, Uribe-Rodríguez, D, Ramírez-Arreola, DE et al.. Extracellular Vesicles from Different Mesenchymal Stem Cell Types Exhibit Distinctive Surface Protein Profiling and Molecular Characteristics: A Comparative Analysis. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26073393. PubMed PMID:40244251 PubMed Central PMC11989379.
  93. Musílková, J, Beran, M, Sedlář, A, Slepička, P, Bartoš, M, Kolská, Z et al.. Composite Polylactide/Polycaprolactone Foams with Hierarchical Porous Structure for Pre-Vascularized Tissue Engineering. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072974. PubMed PMID:40243624 PubMed Central PMC11988939.
  94. Palazzo, E, Lotti, R, Quadri, M, Pincelli, C, Marconi, A. IL-17 Ligand and Receptor Family Members Are Differentially Expressed by Keratinocyte Subpopulations and Modulate Their Differentiation and Inflammatory Phenotype. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072989. PubMed PMID:40243580 PubMed Central PMC11988555.
  95. Srimaneepong, V, Trachoo, V, Phothichailert, S, Srithanyarat, SS, Mahanonda, R, Norbert, H et al.. Evaluating Surface Properties and Cellular Responses to Surface-Treated Different Triple Periodic Minimal Surface L-PBF Ti6Al4V Lattices for Biomedical Devices. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072960. PubMed PMID:40243578 PubMed Central PMC11988758.
  96. Yang, H, Yuan, F, Song, J, Huang, Y, Shan, Z, Fan, Z et al.. m6A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla. Int J Mol Sci. 2025;26 (7):. doi: 10.3390/ijms26072920. PubMed PMID:40243520 PubMed Central PMC11988903.
  97. Lin, TY, Mishra, VK, Dubey, R, Chaturvedi, TP, Narayan, SA, Fang, HW et al.. Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2025; :. doi: 10.5507/bp.2025.008. PubMed PMID:40242907 .
  98. Del Vecchio, V, Sanchez-Pajares, IR, Panda, SK, Rehman, A, De Falco, V, Nigam, A et al.. Xanthohumol modulate autophagy and ER stress to counteract stemness and enhance cisplatin efficacy in head and neck squamous cell carcinoma. Sci Rep. 2025;15 (1):13137. doi: 10.1038/s41598-025-98003-1. PubMed PMID:40240816 PubMed Central PMC12003764.
  99. Kandettu, A, Ghosal, J, Tharayil, JS, Kuthethur, R, Mallya, S, Narasimhamurthy, RK et al.. Inhibition of mitochondrial genome-encoded mitomiR-3 contributes to ZEB1 mediated GPX4 downregulation and pro-ferroptotic lipid metabolism to induce ferroptosis in breast cancer cells. Free Radic Biol Med. 2025;234 :151-168. doi: 10.1016/j.freeradbiomed.2025.04.019. PubMed PMID:40239722 .
  100. Manokawinchoke, J, Limraksasin, P, Limjeerajarus, CN, Limjeerajarus, N, Samaranayake, LP, Egusa, H et al.. Mechanical Force Induces Osteogenic Differentiation of Murine Induced Pluripotent Stem Cells via TGF-β Signalling. Orthod Craniofac Res. 2025; :. doi: 10.1111/ocr.12933. PubMed PMID:40238110 .
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