Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Patel, T, Henna, F, Sharif, I, Javed, I, Mustafa, F, Sharif, H et al.. A narrative review on the therapeutic potential of stem cells in neurodegenerative diseases: advances, insights, and challenges. Ann Med Surg (Lond). 2026;88 (2):1441-1453. doi: 10.1097/MS9.0000000000004490. PubMed PMID:41675725 PubMed Central PMC12889343.
  2. Liu, K, Tian, Y, Mu, R, Wang, X, Xin, M, Ding, H et al.. Graphene oxide coating on two-dimensional glass substrates and three-dimensional zirconia scaffolds for bone tissue regeneration. Mater Today Bio. 2026;37 :102852. doi: 10.1016/j.mtbio.2026.102852. PubMed PMID:41675674 PubMed Central PMC12887784.
  3. Amemiya, T, Ouchi, T, Kimura, H, Okuyama, K, Phan, TQ, Iwamoto, T et al.. Enhanced nerve regeneration after transplantation of NCAM-positive neural crest-like cells derived from human iPSC. Inflamm Regen. 2026; :. doi: 10.1186/s41232-026-00409-5. PubMed PMID:41673753 .
  4. Sarra, G, Parsaei, S, Gomes, MP, Lin, YC, Pedroni, AC, Raval, D et al.. Sfrp4 Is Required for Proper Dental Formation and Stem Cell Regulation. J Dent Res. 2026; :220345261416408. doi: 10.1177/00220345261416408. PubMed PMID:41673565 .
  5. Dong, H, Guan, L, Zhong, J, Lai, F, Lin, L, Li, M et al.. Circ_015350 Mediates Odonto/osteogenic Differentiation in Different Stem Cells. J Dent Res. 2026; :220345251407609. doi: 10.1177/00220345251407609. PubMed PMID:41673513 .
  6. Mendes Soares, IP, Liepman, O, Anselmi, C, Chang, S, Hebling, J, Dal-Fabbro, R et al.. Hesperetin modulates osteoprogenitor cells and macrophages under zoledronic acid and inflammatory stress. Arch Oral Biol. 2026;185 :106538. doi: 10.1016/j.archoralbio.2026.106538. PubMed PMID:41671744 .
  7. Luong, NP, Kim, KH, Kook, JE, Seol, YJ. Bone regenerative capacity of the newly synthesized material QG3030: an in vitro and in vivo study. J Periodontal Implant Sci. 2025; :. doi: 10.5051/jpis.2502920146. PubMed PMID:41667139 .
  8. Li, CS, Zhang, X, Liu, H, Feng, Y, Wang, L, Zhou, M et al.. Transgenic high expression of EphB4 in canine periodontal ligament stem cells modulates osteogenic differentiation and migration in cPDLSCs. Biomed Eng Online. 2026; :. doi: 10.1186/s12938-026-01533-6. PubMed PMID:41664138 .
  9. Montero-Del-Toro, JA, Serralta-Interian, AA, Torres-Romero, JC, Rojas-Herrera, R, Rodas-Junco, BA. Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications. Mol Biol Rep. 2026;53 (1):372. doi: 10.1007/s11033-026-11536-0. PubMed PMID:41661344 .
  10. Yan, X, Li, X, Zhang, Q, He, X, Chen, Q, Mai, S et al.. Magnesium-doped bioactive glass enhances bone regeneration by reversing replicative senescence of human dental pulp stem cells in bone defect therapy. Regen Biomater. 2026;13 :rbaf105. doi: 10.1093/rb/rbaf105. PubMed PMID:41660064 PubMed Central PMC12872399.
  11. Ricardo, S, Kamano, Y, Saito, M, Bagio, DA, Julianto, I, Margono, A et al.. Wharton's jelly mesenchymal stem cell-derived exosomes promote odontogenic differentiation of dental pulp stem cells: A cell-free strategy for regenerative endodontics. J Conserv Dent Endod. 2026;29 (1):20-25. doi: 10.4103/JCDE.JCDE_644_25. PubMed PMID:41660034 PubMed Central PMC12880776.
  12. Hadi, S, Widyastuti, W, Ratnasari, D, Amtha, R. Novel acemannan-integrated bioceramic for enhancing human dental pulp stem cell viability and transforming growth factor beta-1 release in pulp regeneration. J Conserv Dent Endod. 2026;29 (1):31-35. doi: 10.4103/JCDE.JCDE_910_25. PubMed PMID:41660021 PubMed Central PMC12880772.
  13. Hazrati, P, Alanazi, A, Alrmali, AE, Galindo-Fernandez, P, Kassem, H, Kaigler, D et al.. Clinical stem cell therapy in oral and craniofacial bone regeneration: a systematic review and meta-analysis. Front Bioeng Biotechnol. 2026;14 :1677400. doi: 10.3389/fbioe.2026.1677400. PubMed PMID:41658988 PubMed Central PMC12876186.
  14. Dixit, S, Shayeb, MA, Kathayat, G, Rokaya, D. Clinical translation of 3D bioprinting in oral and maxillofacial reconstruction: Recent progress and future directions. J Oral Biol Craniofac Res. 2026;16 (2):101401. doi: 10.1016/j.jobcr.2026.01.005. PubMed PMID:41658370 PubMed Central PMC12877813.
  15. Asgary, S, Shamszadeh, S. Immunomodulatory and angiogenic strategies in vital pulp therapy: a systematic review of scaffold-based, scaffold-free, and cell-laden interventions. Clin Oral Investig. 2026;30 (2):73. doi: 10.1007/s00784-025-06737-z. PubMed PMID:41656373 .
  16. Anaya-Sampayo, LM, Garcia-Robayo, DA, Roa, NS, Rodriguez-Lorenzo, LM, Martinez-Cardozo, C. Lyophilized L-PRF enhances the bioactivity and rheological properties of 3D-printed and bioprinted scaffolds containing Dental pulp stem cells. Dent Mater. 2026; :. doi: 10.1016/j.dental.2026.01.013. PubMed PMID:41656139 .
  17. Liu, L, Li, J, Sun, B, Han, C, Shi, S, Ma, G et al.. Osteogenic efficacy of partially demineralized dentin block in dental implant rehabilitation following alveolar ridge augmentation. J Stomatol Oral Maxillofac Surg. 2026; :102742. doi: 10.1016/j.jormas.2026.102742. PubMed PMID:41654303 .
  18. Chandramouli, A, Babu, R, Gopal, K, Sri Manjari, R, Kaliannagounder, VK, Park, CH et al.. Antibacterial alginate hydrogel coated composite bone cement beads to treat osteomyelitis and regeneration. Int J Biol Macromol. 2026; :150761. doi: 10.1016/j.ijbiomac.2026.150761. PubMed PMID:41654041 .
  19. Vignolo, SM, Roth, DM, Fraga, MAA, Wu, L, Cosgrove, JA, Athirasala, A et al.. Engineering bioinspired, high-density collagen microgels with tunable intrafibrillar mineralization for accelerated osteogenesis in vitro and bone regeneration in vivo. Acta Biomater. 2026; :. doi: 10.1016/j.actbio.2026.02.003. PubMed PMID:41651322 .
  20. Ding, S, Shi, Y. Long Noncoding RNA SATB1-AS1 Suppresses Inflammatory Response and Injury in Dental Pulp Stem Cells Through the miR-15a-5p/E2F3 Axis. Int Dent J. 2026;76 (2):109412. doi: 10.1016/j.identj.2026.109412. PubMed PMID:41650832 .
  21. Li, M, Liu, X, Xu, J, Zhou, Q, Wang, Z. EXO-VNN2 derived from 3D-cultured DPSCs enhances the inflammatory response of PDLSCs and suppresses bone regeneration in periodontitis. Stem Cell Res Ther. 2026; :. doi: 10.1186/s13287-026-04922-9. PubMed PMID:41645264 .
  22. Antonio-Ríos, G, Ribas-Aparicio, RM, Leyva-Gómez, G, Soldevila, G, Dueñas, KAE, Trejo-Iriarte, CG et al.. The Impact of Large-Scale Expansion on the Functional Properties of Mesenchymal Stem Cells. Stem Cell Rev Rep. 2026; :. doi: 10.1007/s12015-026-11068-x. PubMed PMID:41644937 .
  23. Silva, P, Garrido, M, Tapia, HA, Ormeño, D, Benito, S, Segura, J et al.. Histatin-1 promotes the expression of markers associated with odontoblastic differentiation in the dental pulp and apical papilla. Sci Rep. 2026; :. doi: 10.1038/s41598-026-38578-5. PubMed PMID:41644616 .
  24. Park, JJ, Seo, E, Gwak, H, Lee, S, Kim, J, Lee, J et al.. Application of Adipose-Derived Mesenchymal Stem Cell 3D Spheroid, Microblock, as a Skin Regeneration Therapy. Eur J Pharmacol. 2026; :178637. doi: 10.1016/j.ejphar.2026.178637. PubMed PMID:41643832 .
  25. Hao, J, Zakershahrak, M, Ly, P, Le, AD, Yu, W, Gates, JC et al.. Stromal cells contribute to progression, recurrence, and metastasis in oral squamous cell carcinoma: a call for therapy. J Transl Med. 2026; :. doi: 10.1186/s12967-026-07786-y. PubMed PMID:41639847 .
  26. Wei, X, Shen, J, Dai, H, Wu, Z, Zheng, X, Xu, Z et al.. 3D-printed PCL scaffolds functionalized with GelMA for sustained delivery of human dental follicle stem cell-derived conditioned medium in bone regeneration. Colloids Surf B Biointerfaces. 2026;262 :115486. doi: 10.1016/j.colsurfb.2026.115486. PubMed PMID:41638003 .
  27. Lnu, N, Pandya, M, Luan, J, Ding, Y, Luan, X, Diekwisch, TG et al.. The Enamel Matrix Protein Amelogenin is Essential for Enamel Mineral Transport and Deposition. Stem Cells Dev. 2026; :15473287261418985. doi: 10.1177/15473287261418985. PubMed PMID:41636099 .
  28. Qin, Z, You, J, Wu, Q, Maimaiti, A, Li, J, Wang, Q et al.. A Self-Adaptive Periodontal Ecosystem Engineered With Molybdenum-Based Nanozyme-Embedded Composite Hydrogel for Microenvironment-Responsive Precision Therapy. Adv Mater. 2026; :e22859. doi: 10.1002/adma.202522859. PubMed PMID:41635061 .
  29. Gao, R, Ma, T, Wang, R, Yin, Y, Li, R, Wang, D et al.. [Anti-inflammatory effects of cell membrane vesicle-mediated delivery of small interfering RNA targeting tumor necrosis factor-α on dental pulp stem cells]. Beijing Da Xue Xue Bao Yi Xue Ban. 2026;58 (1):22-29. doi: 10.19723/j.issn.1671-167X.2026.01.003. PubMed PMID:41633581 PubMed Central PMC12872366.
  30. Fadhila, O, Ridwan, RD, Yastuti, WTP, Yuliati,, Diyatri, I, Margaretha, SA et al.. Application of an MTT-Based Colorimetric Assay to Evaluate SHED Metabolites in Inhibiting Oral Bacteria Growth. Eur J Dent. 2026; :. doi: 10.1055/s-0045-1812497. PubMed PMID:41633372 .
  31. Jo, BS, Lee, DW, Lee, JY, Seok, S, Kim, YB, Lee, JY et al.. A Multifunctional β-Defensin-3 Mimetic Peptide Modulates Host-Biofilm Interactions and Reduces Bone Loss in Periodontitis. J Periodontal Res. 2026; :. doi: 10.1111/jre.70079. PubMed PMID:41631454 .
  32. Kocaayan, SG, Pulat, G, Cevik, Z, Enhos, S. Osteogenic Differentiation on Nonthermal Atmospheric Plasma-Treated versus SLActive® Titanium and Titanium-Zirconium Implants: An In Vitro Comparative Study. Niger J Clin Pract. 2026;29 (1):30-42. doi: 10.4103/njcp.njcp_534_25. PubMed PMID:41631304 .
  33. Tsutsumi, H, Chiba, T, Fujii, Y, Matsushima, T, Kimura, T, Kanai, A et al.. Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells. Elife. 2026;14 :. doi: 10.7554/eLife.104768. PubMed PMID:41627310 PubMed Central PMC12863719.
  34. Patil, S, Pawar, M, Kharat, A, Mante, N, Panamgipalli, S, Kheur, S et al.. Effect of Baicalein on Odontogenic Differentiation of Dental Pulp Stem Cells: An In Vitro Study. Int J Clin Pediatr Dent. 2026;19 (1):92-99. doi: 10.5005/jp-journals-10005-3455. PubMed PMID:41624368 PubMed Central PMC12855021.
  35. Tobita, M, Masubuchi, Y, Ogata, Y, Mitani, A, Kikuchi, T, Hayashi, JI et al.. Efficacy and safety of autologous adipose-derived stem cells combined with platelet-rich plasma for periodontal regeneration: a multicenter, randomized, open-label, parallel-group comparative trial. Regen Ther. 2026;31 :101062. doi: 10.1016/j.reth.2026.101062. PubMed PMID:41624073 PubMed Central PMC12855574.
  36. Cadelano, F, Giannasi, C, Rossi, N, Della Morte, E, Niada, S, Talò, G et al.. Evaluation of MSC-Secretome Effects in an Ex Vivo Compartmentalized Osteochondral Interface Model. Stem Cells Int. 2026;2026 :3275855. doi: 10.1155/sci/3275855. PubMed PMID:41624062 PubMed Central PMC12860394.
  37. Pokharel, E, Kim, TY, Rana, B, Jang, JH, Lee, JH, An, SY et al.. Thiamet-G facilitates reparative dentin formation via modulating O-GlcNAcylation and inflammation. Front Physiol. 2025;16 :1739168. doi: 10.3389/fphys.2025.1739168. PubMed PMID:41624019 PubMed Central PMC12855040.
  38. Sui, H, Wu, Z, Xiong, Z, Zhang, H, Heng, BC, Zhou, J et al.. Spatiotemporal application of small molecules in fracture healing. Biomater Transl. 2025;6 (4):416-436. doi: 10.12336/bmt.24.00087. PubMed PMID:41623945 PubMed Central PMC12852077.
  39. Varghese, MG, Valliaveettil, TG, Puthanpurakkalkizhakkethil Kamalamma, B, Varghese, N, Dalvi, YB, Thomas, NG et al.. Development and evaluation of a fish skin-derived acellular dermal matrix for diabetic wound healing: In vitro and in vivo assessment. J Biomater Appl. 2026; :8853282261422121. doi: 10.1177/08853282261422121. PubMed PMID:41616380 .
  40. Zhang, L, Xu, X, Tao, D, Li, X, Niu, P, Gong, X et al.. Primary cilia in growth plates orchestrate long bone development. Fundam Res. 2025;5 (5):2368-2381. doi: 10.1016/j.fmre.2025.04.014. PubMed PMID:41613437 PubMed Central PMC12848162.
  41. Chen, J, Di, J, Yu, Q, Xiao, H, Wang, T, He, L et al.. Strontium-doped hydroxyapatite microspheres loaded with iloprost promote dentin-pulp complex regeneration. Front Bioeng Biotechnol. 2025;13 :1726285. doi: 10.3389/fbioe.2025.1726285. PubMed PMID:41613153 PubMed Central PMC12847251.
  42. Wang, R, Cheng, Y, Chen, H, Shan, W, Qiao, Y, Wu, J et al.. SHED-exosome-functionalized degradable fibrous coatings: Immunomodulatory engineering of titanium implant interfaces. Colloids Surf B Biointerfaces. 2026;262 :115479. doi: 10.1016/j.colsurfb.2026.115479. PubMed PMID:41610645 .
  43. Arunratanothai, T, Chuenjitwongsa, S, Tavedhikul, K, Sumrejkanchanakij, P, Fakhruddin, KS, Samaranayake, L et al.. Global Trends in Non-Technical Skills Research in Dental Education: Bibliometric Review and a Curricular Case Study. Int J Dent. 2026;2026 :8633389. doi: 10.1155/ijod/8633389. PubMed PMID:41608111 PubMed Central PMC12835188.
  44. Ahmad, P, Siddiqui, DA, Bianchi-Smak, J, Farshidfar, N, Estrin, N, Miron, RJ et al.. Effects of Periodontal-Specific Exosomes and rhBMP2 on Osteogenic Behaviour and Differentiation of BMSCs. J Cell Mol Med. 2026;30 (3):e71039. doi: 10.1111/jcmm.71039. PubMed PMID:41606422 PubMed Central PMC12852057.
  45. Pardo-Díaz, C, Cochinski, G, Moreira, P, Nascimento, FD, Souza Chiari, MDE, de Sousa Gomes Costa, JL et al.. Bioactive and antibacterial universal adhesives containing ZnO/Cu and bioactive glass nanoparticles. J Dent. 2026;167 :106524. doi: 10.1016/j.jdent.2026.106524. PubMed PMID:41605315 .
  46. Liu, B, Du, Y, Wang, M, Zhang, Z, Yin, W, Hu, Y et al.. Effects of the Dental Implant Surface Topography and Macrophage Polarisation on Osteogenesis and Angiogenesis. Int Dent J. 2026;76 (2):109398. doi: 10.1016/j.identj.2025.109398. PubMed PMID:41604948 PubMed Central PMC12873591.
  47. Kim, YK, Kim, SY, Jang, YS, Lee, MH. pH-Responsive mPEG-PLGA/Dexamethasone Coatings for Corrosion Control and Osteo-Immune Modulation of Biodegradable Magnesium. Polymers (Basel). 2026;18 (2):. doi: 10.3390/polym18020303. PubMed PMID:41599597 PubMed Central PMC12846112.
  48. Muresan, CG, Mirica, IC, Forray, A, Petrescu, N, Soritau, O, Gherman, LM et al.. Vitamin D-Loaded Chitosan Nanostructures for Bone Regeneration: A Combined In Vitro and In Vivo Evaluation in an Osteoporotic Rat Model. Medicina (Kaunas). 2025;62 (1):. doi: 10.3390/medicina62010073. PubMed PMID:41597359 PubMed Central PMC12843211.
  49. Policiquio, BO, Fonseca, VG, Santos Costa, G, de Souza, JG, Celia Martinez Ibañez, O, Ribeiro, OG et al.. Human Dental Pulp Stem Cells Modulate Acute Inflammation Kinetics in the AIRmax Murine Model by Sustained TNF-Alpha Suppression and Transient Homing. Cells. 2026;15 (2):. doi: 10.3390/cells15020189. PubMed PMID:41597263 PubMed Central PMC12839598.
  50. Chuah, BH, Law, JX, Leong, XF, Pang, KL, Farm, YR, Razali, M et al.. Safety Assessment of Extracellular Vesicle-Based Therapy in Regenerative Dentistry. Int J Mol Sci. 2026;27 (2):. doi: 10.3390/ijms27020798. PubMed PMID:41596446 PubMed Central PMC12841310.
  51. Nakano, M, Fujii, Y, Matsui-Chujo, Y, Nishimaki, K, Miyazaki, Y, Torii, Y et al.. Enhanced Bone Regeneration by Scaffold-Free Three-Dimensional Constructs of Human Dental Pulp Stem Cells in a Rat Mandibular Defect Model. Int J Mol Sci. 2026;27 (2):. doi: 10.3390/ijms27020651. PubMed PMID:41596303 PubMed Central PMC12841011.
  52. Ochiiwa, H, Wakasa, T, Kataoka, Y, Ando, K, Oki, E, Maehara, Y et al.. IAP Antagonists Selectively Eliminate Therapy-Induced Senescent Cancer Cells via TNFα-Independent Apoptosis. Cancer Sci. 2026; :. doi: 10.1111/cas.70329. PubMed PMID:41591304 .
  53. Jungbluth, H, Lalaouni, D, Winter, J, Jepsen, S, Kraus, D. Differential Expression of S100A Genes in hDPSCs Following Stimulation with Two Hydraulic Calcium Silicate Cements: A Laboratory Investigation. J Funct Biomater. 2026;17 (1):. doi: 10.3390/jfb17010055. PubMed PMID:41590823 PubMed Central PMC12843100.
  54. Rodríguez-Lozano, FJ, Pérez-Guzmán, N, García-Rios, P, García-Bernal, D, Lozano, A, López-García, S et al.. In Vitro Evaluation of Novel Calcium Silicate-Based and Resin-Modified Calcium Silicate Materials: Cytocompatibility and Mineralization Potential on Human Dental Pulp Stem Cells for Pulp Repair. Microsc Res Tech. 2026; :. doi: 10.1002/jemt.70121. PubMed PMID:41588682 .
  55. Sadeghi, M, Nazarimoghadam, K, Labbaf, H, Jafari, Z, Chiniforush, N. Effects of photobiomodulation with 450 nm and 635 nm laser wavelengths on the release of TGF-β, BMP-2, FGF-2, and VEGF from dental pulp stem cells. Photochem Photobiol. 2026; :. doi: 10.1111/php.70073. PubMed PMID:41588551 .
  56. Iida, N, Hayashi, Y, Futenma, T, Sakatoku, S, Sugita, Y, Nakamura, K et al.. Wnt10a exhibit spatiotemporal singularity in the temporal changes of angiogenesis in regenerated pulp-like tissue. Inflamm Regen. 2026;46 (1):6. doi: 10.1186/s41232-025-00397-y. PubMed PMID:41588444 PubMed Central PMC12836903.
  57. Svanberg, S, Hanoune, M, Mitsiadis, TA, Dittrich, PS. A microfluidic model of human dental pulp angiogenesis for preclinical drug and biomaterial testing. Mater Today Bio. 2026;37 :102776. doi: 10.1016/j.mtbio.2026.102776. PubMed PMID:41585433 PubMed Central PMC12830287.
  58. Tavakoli, S, Safipour Afshar, A, Mohtasham, N, Samiee, Z, Yaghoubi, MA, Mohajertehran, F et al.. The Effect of Culture Medium Obtained from Dental Pulp Stem Cells (Conditioned Medium) on Esophageal Squamous Cell Carcinoma Cell Line (KYSE-30). Iran J Otorhinolaryngol. 2026;38 (1):11-17. doi: 10.22038/ijorl.2025.84920.3857. PubMed PMID:41585335 PubMed Central PMC12828138.
  59. Renn, TY, Ma, YR, Hsu, CC, Salamanca, E, Egusa, H, Sun, YS et al.. Biofunctionalized 3D-printed gelatin-alginate scaffolds with arginine-glycine-aspartic acid (RGD) peptides for enhanced in vitro osteogenesis. J Dent Sci. 2026;21 (1):484-493. doi: 10.1016/j.jds.2025.10.030. PubMed PMID:41585190 PubMed Central PMC12827005.
  60. Yuan, D, Tao, R, Yin, B, Gu, M. Hypoxic stem cells from apical papilla-derived exosomes enhance dental pulp stem cells migration and differentiation via mitochondrial activation. J Dent Sci. 2026;21 (1):67-77. doi: 10.1016/j.jds.2025.07.028. PubMed PMID:41585148 PubMed Central PMC12825481.
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