The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.
Dental Stem Cell Research
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- Abd-Elmonsif, NM, Morsy, A, Deeb, ME. Enhanced odontoblast regeneration and anti-inflammatory effects of nanocurcumin-loaded BM-MSC-derived exosomes in an LPS-induced periodontitis rat model. BMC Oral Health. 2026;26 (1):. doi: 10.1186/s12903-026-09697-2. PubMed PMID:42698076 PubMed Central PMC13543616.
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- Takematsu, E, Lachmansingh, RN, Johnston, K, Hou, S, Bailey, E, Wang, Y et al.. Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration. Nat Commun. 2026;17 (1):. doi: 10.1038/s41467-026-76286-w. PubMed PMID:42693126 PubMed Central PMC13542091.
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- Yang, Y, Du, W, Yang, D, Luo, Y, Zhou, Q, Zuo, D et al.. Membrane Potential Hyperpolarization Controls the Osteogenic Differentiation of Human Dental Follicle Stem Cells by Increasing Intracellular Ca2+ Levels. Front Biosci (Landmark Ed). 2026;31 (8):53140. doi: 10.31083/FBL53140. PubMed PMID:42689977 .
- Tsai, YS, Cheng, SJ, Chuang, TL, Chang, SF, Lin, FH, Lin, CP et al.. Development and characterization of an exosome-loaded biomimetic hydroxyapatite/gelatin scaffold for enhanced dental pulp regeneration. J Dent Sci. 2026;21 (2):985-996. doi: 10.1016/j.jds.2025.11.017. PubMed PMID:42689128 PubMed Central PMC13536453.
- Torelli, F. Optogenetic control of odontoblastic differentiation in dental pulp stem cells (DPSC). J Dent Sci. 2026;21 (3):1756-1763. doi: 10.1016/j.jds.2025.07.3543. PubMed PMID:42689111 PubMed Central PMC13536420.
- Sun, YS, Lin, KY, Chen, WC, Huang, HH. Dual-layer biphasic calcium phosphates/tantalum pentoxide coating on titanium for concurrent biocorrosion resistance and enhanced biocompatibility. J Dent Sci. 2026;21 (3):1449-1458. doi: 10.1016/j.jds.2025.07.3446. PubMed PMID:42689074 PubMed Central PMC13536408.
- Nugraha, AP, Hong, G, Yang, K, Narmada, IB, Rantam, FA, Ernawati, DS et al.. Mesenchymal stem cells derived from gingiva normoxic or hypoxic-preconditioning allogenous transplantation affect orthodontic tooth movement in vivo. J Dent Sci. 2026;21 (3):1801-1808. doi: 10.1016/j.jds.2025.07.3548. PubMed PMID:42689049 PubMed Central PMC13536401.
- Song, SE, Yun, G, Kim, CH, Yoon, JY, Kim, HY, Kim, HJ et al.. Dual effects of 1α,25-dihydroxyvitamin D3 on inflammation and osteogenic differentiation in lipopolysaccharide-stimulated dental pulp stem cells. J Dent Sci. 2026;21 (3):1948-1957. doi: 10.1016/j.jds.2025.07.3564. PubMed PMID:42689044 PubMed Central PMC13536342.
- Sirisereephap, K, Pasanaphong, K, Osathanon, T, Promoppatum, P, Maekawa, T, Srimaneepong, V et al.. Synergistic effects of biodegradable magnesium alloy and erythromycin on osteogenic activity. J Dent Sci. 2026;21 (3):1627-1635. doi: 10.1016/j.jds.2025.07.3462. PubMed PMID:42688957 PubMed Central PMC13536291.
- Kalantari, M, Malekhoseini, N, Malekpour Afshar, R, Fouladi, S. Overexpression of MIEN1 in Oral Squamous Cell Carcinoma: Correlation with Tumor Invasion and Lymph Node Metastasis. J Dent (Shiraz). 2026;27 (3):252-258. doi: 10.30476/dentjods.2025.106409.2659. PubMed PMID:42688861 PubMed Central PMC13535677.
- Hayashi, I, Nakamura-Yamada, S, Abe, K, Ito, E, Katagiri, W, Miyazaki, T et al.. The utility of 3D nanostructured polyglycolic acid fibers for novel bone regenerative medicine. J Dent Sci. 2026;21 (3):1892-1903. doi: 10.1016/j.jds.2025.07.3558. PubMed PMID:42688652 PubMed Central PMC13536381.
- Sawutdeechaikul, P, Pimpakan, T, Van Phan, T, Rosa, V, Ferreira, JN. From human dental pulp stem cells to functional cholinergic neurons: An optimized neurogenic differentiation protocol for new approach methodologies. J Dent Sci. 2026;21 (2):781-791. doi: 10.1016/j.jds.2025.10.025. PubMed PMID:42688638 PubMed Central PMC13536296.
- Belenichev, I, Popazova, O, Dmytriieva, O, Chertov, S, Bukhtiyarova, N, Ryzhenko, V et al.. Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment. Front Dent Med. 2026;7 :1849807. doi: 10.3389/fdmed.2026.1849807. PubMed PMID:42688516 PubMed Central PMC13535533.
- Luo, H, Li, S, Tian, Q, Gao, J, Li, Z, Zheng, L et al.. Glutathione Primes Mitochondrial Autophagy to Guide Pulp-Dentine Complex Repair. Int Endod J. 2026; :. doi: 10.1111/iej.70240. PubMed PMID:42687338 .
- Xing, X, Hao, Y, Zhang, G, Xing, X, Jia, H, Liu, C et al.. Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury. CNS Neurosci Ther. 2026;32 (9):e71133. doi: 10.1002/cns.71133. PubMed PMID:42687121 PubMed Central PMC13538453.
- Isogai, S, Okabe, A, Tanaka, K, Nakagawa, T, Izumi, S, Fukuyo, M et al.. Epstein-Barr virus-associated chromatin activation and enhancer engagement in T/NK-cell lymphoproliferative diseases. Blood. 2026; :. doi: 10.1182/blood.2025032640. PubMed PMID:42685000 .
- Su, X, Zhang, Y, Lv, T, Wang, B, Pang, R, Guo, F et al.. Photothermal-responsive dexmedetomidine-loaded MPDA-GelMA hydrogel promotes bone regeneration. J Mater Chem B. 2026; :. doi: 10.1039/d6tb01440b. PubMed PMID:42684198 .
- Carvalho, LAM, Rodriguez-Sanchez, DN, Müller, KS, Balzani, MFV, Mancilla-Corzo, IJ, d'Ávila, MA et al.. Multifunctional Three-Dimensional Bioprinted Scaffolds Reduce Epidural Fibrosis and Promote Bone Regeneration in a Laminectomy Model. ACS Appl Bio Mater. 2026; :. doi: 10.1021/acsabm.6c01134. PubMed PMID:42683558 .
- Kannan, G, Kumar, G, Ravishankar, PL, Solomon, G, Varatharajan, K, Paneerselvan, VE et al.. Exosome-based strategies for periodontal regeneration: Current insights and future prospects (Review). Med Int (Lond). 2026;6 (5):50. doi: 10.3892/mi.2026.334. PubMed PMID:42682920 PubMed Central PMC13531124.
- Shao, D, Yao, Z. MicroRNA signatures in inflammatory dental tissues: biomarkers and molecular mechanisms. Front Mol Biosci. 2026;13 :1881450. doi: 10.3389/fmolb.2026.1881450. PubMed PMID:42682623 PubMed Central PMC13530013.
- Yamada, M, Hase, H, Kitamura, H, Morie, T, Aoi, S, Ueda, Y et al.. An ALKBH3 Inhibitor HUHS199 Suppresses Proliferation of Glioblastoma Cells by Targeting 1-Methyladenosine on GADD45A mRNA. Chem Biol Drug Des. 2026;108 (3):e70385. doi: 10.1111/cbdd.70385. PubMed PMID:42681921 PubMed Central PMC13534923.
- GBD 2023 Asia Pacific Adolescent Health Collaborators. Adolescent health across Asia Pacific, 2000-23: a systematic analysis for the Global Burden of Disease Study 2023. Lancet Child Adolesc Health. 2026;10 (10):731-754. doi: 10.1016/S2352-4642(26)00163-X. PubMed PMID:42679829 .
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- Li, Y, Shi, H, He, W, Qiao, Y, Xue, H, Liu, X et al.. A zinc-iron nanozyme with pH-dependent multi-enzymatic activities for sequential infection control and inflammation resolution in vital pulp therapy. Biomater Sci. 2026; :. doi: 10.1039/d6bm00827e. PubMed PMID:42678408 .
- Antunes Teixeira, P, Fernandes de Magalhães Silveira, C, Sigrist de Martin, A, Silveira Bueno, CE, Rangel-Coelho, JP, Ferreira Martinez, E et al.. Effects of resveratrol-enriched endodontic sealants on pulp stem cell viability and collagen production. Acta Odontol Latinoam. 2026;39 (1):36-42. doi: 10.54589/aol.39/1/36. PubMed PMID:42678110 PubMed Central PMC13543400.
- Bai, Z, Gui, X, Zhang, B, He, X, Peng, H, Zhou, C et al.. Construction of biomimetic hydroxyapatite bilayer scaffolds via DLP 3D printing for bio-root regeneration. J Mater Chem B. 2026; :. doi: 10.1039/d6tb01226d. PubMed PMID:42677996 .
- Wang, X, Hu, X, Sheng, R, Wang, R, Huang, X, Huang, T et al.. Multimodal extracellular osteogenic microenvironment orchestrating with piezoelectric collagen fibrils for promoting bone regeneration. J Mater Chem B. 2026; :. doi: 10.1039/d6tb01059h. PubMed PMID:42677855 .
- Kim, W, Park, S, Beom, SW, Choi, S, Yang, HW, Kim, D et al.. Regenerative Nano-scaffolds for Tissue Engineering: From Bench to Clinical Translation. Biomater Res. 2026;30 :0414. doi: 10.34133/bmr.0414. PubMed PMID:42676842 PubMed Central PMC13527211.
- Song, J, Song, W, Liu, P, Zhou, Y, Chi, X, You, F et al.. RNA-binding protein OTUD1 maintains skeletal homeostasis by determining mesenchymal stem cell lineage commitment. Cell Rep. 2026;45 (9):117932. doi: 10.1016/j.celrep.2026.117932. PubMed PMID:42671913 .
- Ahmad, P, Estrin, NE, Sculean, A, Miron, RJ. Understanding extracellular vesicles in antiaging. Periodontol 2000. 2026; :. doi: 10.1111/prd.70070. PubMed PMID:42670765 .
- Zhang, B, Wang, J, Wang, T, Zong, Z, Liu, X, Xu, Z et al.. Targeting Fibrin Deposit Alleviates Periodontitis via Neutrophil Modulation. J Dent Res. 2026; :220345261468280. doi: 10.1177/00220345261468280. PubMed PMID:42670331 .
- Nabbout, F, Ghassibe, M, Sabbagh, J. Calcium Channel Subunit Alpha2delta 2 Is Upregulated During Odontoblast-Like Differentiation and Exhibits Higher Basal Expression in Stem Cells From Exfoliated Deciduous Teeth Than in Dental Pulp Stem Cells. Cureus. 2026;18 (7):e113676. doi: 10.7759/cureus.113676. PubMed PMID:42669006 PubMed Central PMC13525845.
- de Souza, W, Gemini-Piperni, S, Grenho, L, Ribeiro, F, Wiechers, D, Meneses, J et al.. Titanium dioxide nanoparticles alter mesenchymal stem cell function and exosome signalling: Possible implications in periprosthetic osteolysis. Biomater Adv. 2026;190 :215135. doi: 10.1016/j.bioadv.2026.215135. PubMed PMID:42664867 .
- Sarker, MD, Zong, C, Hoang, LAP, Jeong, HJ, Kumar, V, Zhu, E et al.. Nano-layered tendon patch to orchestrate timely interactions between tendon stem/progenitor cells and macrophages. Biomaterials. 2026;337 :124580. doi: 10.1016/j.biomaterials.2026.124580. PubMed PMID:42664711 PubMed Central PMC13542791.
- Li, P, Zhang, S, Zhang, W, Zhao, S, Shang, C, Pan, S et al.. Exosomes Loaded With MiR-21 Promote Differentiation of Dental Pulp Stem Cells Into Endothelial Cells. Int Dent J. 2026;76 (5):109790. doi: 10.1016/j.identj.2026.109790. PubMed PMID:42664586 PubMed Central PMC13545710.
- Keerthika, MR, Surendran, S, Natanasabapathy, V, Chandrasekaran, S, Vasudevan, A, Baskar, K et al.. Biocompatibility of carbazochrome sodium sulfonate on human dental pulp stem cells: An in vitro investigation. J Conserv Dent Endod. 2026;29 (8):909-915. doi: 10.4103/JCDE.JCDE_457_26. PubMed PMID:42663002 PubMed Central PMC13521543.
- Panchal, P, Rauwel, P, Coconubo-Guio, L, Hermosa, G, Gautam, S, Nehra, SP et al.. Mechanistic Investigation of Visible-Light-Driven Photocatalysis in Bio-Synthesized Graphitic Carbon Nitride/MgO Nanocomposites Toward Safranine Orange Dye. ACS Omega. 2026;11 (33):49651-49668. doi: 10.1021/acsomega.6c03815. PubMed PMID:42662624 PubMed Central PMC13520051.
- Khurshid, G, Chaithanya, R, Panda, A, Changani, K, Menat, S, Pandya, H et al.. Clinical efficiency of mesenchymal stem cells for bone regeneration and osseointegration. Bioinformation. 2026;22 (5):2949-2952. doi: 10.6026/973206300222949. PubMed PMID:42662317 PubMed Central PMC13519413.
- Qu, Y, Liu, H, Wang, Y, Gao, S, Huang, H, Li, J et al.. ISL1 regulates the differentiation and maintenance of dental epithelial stem cells in the incisor. FEBS J. 2026; :. doi: 10.1111/febs.70713. PubMed PMID:42657520 .
- AlMaimouni, Y, Yuan, W, Houtari, S, Moshaverinia, A. Application of dynamic hydrogels for dental pulp regeneration: a comparative study on cellular behavior and inflammatory modulation. Front Dent Med. 2026;7 :1847615. doi: 10.3389/fdmed.2026.1847615. PubMed PMID:42656218 PubMed Central PMC13506308.
- Guerrero, J, Ghayor, C, Domínguez, AP, Bhattacharya, I, Weber, FE. Matrix-Bound and Media-Derived Extracellular Vesicles from Mineralized Osteoblasts Exhibit Distinct Osteogenic Activities. Int J Mol Sci. 2026;27 (16):. doi: 10.3390/ijms27167400. PubMed PMID:42653403 PubMed Central PMC13513129.
- Masson-Meyers, DS, Omidi, M, Toth, JM. Cytocompatibility and antibacterial properties of copper-magnesium nanoparticles for potential dental applications. J Oral Biosci. 2026;68 (5):100812. doi: 10.1016/j.job.2026.100812. PubMed PMID:42648020 .
- Zhao, T, Edwards, AM, Celiz, AD, Jones, JR. Antimicrobial Gelatin Methacryloyl (GelMA)/Bioactive Glass Dental Adhesives. J Funct Biomater. 2026;17 (8):. doi: 10.3390/jfb17080394. PubMed PMID:42646197 PubMed Central PMC13514707.
- Shopova, D, Aleksandrov, S, Hristozova, MI. Functional Biomaterials and 3D Bioprinting Approaches for Temporomandibular Joint Reconstruction: A Narrative Review. J Funct Biomater. 2026;17 (8):. doi: 10.3390/jfb17080390. PubMed PMID:42646193 PubMed Central PMC13514935.
- Kim, YK, Niu, W, Love, CJ, Spector, M. Mechanotransductive Osteogenesis Through Microarchitectural Stabilization in an Injectable Hydrogel-Mineral System. J Funct Biomater. 2026;17 (8):. doi: 10.3390/jfb17080389. PubMed PMID:42646192 PubMed Central PMC13514390.
- Milic, MS, Simonovic, J, Todorovic, VS. Cellular Responses at the Zirconia Dental Implant Interface: A Comprehensive Review. J Funct Biomater. 2026;17 (8):. doi: 10.3390/jfb17080372. PubMed PMID:42646175 PubMed Central PMC13514665.
- Pérez-Bohórquez, JM, Acero-Garzón, MC, Gutiérrez-Prieto, SJ, Méndez-Pinzón, HA, Perdomo-Lara, SJ, Rodríguez-Hernández, H et al.. HAp/PLGA/Chitosan Scaffolds Fabricated by Freeze-Drying and 3D Printing for Bone Regeneration: In Vitro Evaluation and Finite Element Analysis. Biomimetics (Basel). 2026;11 (8):. doi: 10.3390/biomimetics11080537. PubMed PMID:42645254 PubMed Central PMC13509448.
- Anselmi, C, Aminmansour, S, Mendes Soares, IP, Reis-Prado, AHD, Aminmansour, S, Liepman, O et al.. Polymer Composition Modulates Dental Stem Cell Response and Mineralization in Electrospun Scaffolds for Hard Tissue Regeneration. Biomimetics (Basel). 2026;11 (8):. doi: 10.3390/biomimetics11080518. PubMed PMID:42645235 PubMed Central PMC13510016.
- Ijaz, A, Phothichailert, S, Fitri, AR, Zohaib, S, Suwittayarak, R, Kornsuthisopon, C et al.. SHED-derived small extracellular vesicles as potential neuro-immune modulators in Alzheimer's disease. J Oral Biosci. 2026;68 (5):100811. doi: 10.1016/j.job.2026.100811. PubMed PMID:42641475 .
- Park, CY, Moon, JH, Lee, SM, Lee, EH, Park, JY, Kim, SY et al.. Serum-induced recovery of proliferative capacity and differentiation potential in aged dental pulp stem cells. Stem Cells Transl Med. 2026;15 (9):. doi: 10.1093/stcltm/szag072. PubMed PMID:42641051 PubMed Central PMC13505630.
- Park, HJ, Lee, HS, Lee, Y, Yu, JH, Yang, JW, Ahn, JS et al.. Optimization of a Canine Colon Organoid Platform for Modeling Intestinal Injury and Mesenchymal Stem Cell-Mediated Regeneration. Int J Stem Cells. 2026; :. doi: 10.15283/ijsc26011. PubMed PMID:42638344 .
- Ham, DW, Park, CY, Seo, SH, Lee, JE, Lee, EH, Kim, SY et al.. Effect of Adipose-derived Stem Cell Exosomes in Alleviating Experimental Autoimmune Encephalomyelitis by Reducing the Th17-related Immune Response in the Central Nervous System. Curr Neuropharmacol. 2026; :. doi: 10.2174/011570159X464294260728104444. PubMed PMID:42634302 .
- Duan, L, Liang, Y, Huang, X. Editorial: Advancing stem cell and extracellular vesicle therapies for autoimmune and cancer treatment. Front Immunol. 2026;17 :1947245. doi: 10.3389/fimmu.2026.1947245. PubMed PMID:42630327 PubMed Central PMC13493547.
- Calabrese, TC, Rothermund, K, Syed, FN. Effects of size scaling on cellular dynamics and tissue patterning in tooth root organoids. Front Bioeng Biotechnol. 2026;14 :1801110. doi: 10.3389/fbioe.2026.1801110. PubMed PMID:42630311 PubMed Central PMC13493524.
- Dunne, OM, McGarvey, LP, About, I, El-Karim, I, Lundy, FT. Validation of a human peripheral neuronal model for ATP-P2X3 mediated inflammatory pain signalling in the dental pulp. J Endod. 2026; :. doi: 10.1016/j.joen.2026.08.021. PubMed PMID:42628730 .
- Yang, S, Dissanayaka, WL. Targeting Hypoxic Pathways for Dental Pulp Regeneration. J Endod. 2026; :. doi: 10.1016/j.joen.2026.08.029. PubMed PMID:42628729 .
- Ganapathy, A, Chen, Y, Bhakthavatchalam, V, George, A. Molecular Cues from ECM proteins drive the differentiation of dental pulp stem cells into endothelial cells in the presence of Dentin matrix protein 1. J Endod. 2026; :. doi: 10.1016/j.joen.2026.08.017. PubMed PMID:42628728 .
- Morales Valladares, GA, Brizuela Cordero, CI, Betancourt Cisneros, DA, Espinosa Torres, EE, Gallegos Intriago, ME, Palomeque Viteri, KG et al.. Top 100 Most-cited Articles on Stem Cell-based Regenerative Endodontics: A Bibliometric Analysis of Scientific Evolution and Translational Gaps. J Endod. 2026; :. doi: 10.1016/j.joen.2026.08.011. PubMed PMID:42628724 .
- Gagliardi, CF, de Castro Santos, A, Warner, K, Garakis, MCV, Nor, J, Cavalcanti, B et al.. N-acetyl cysteine as an adjuvant medication for regenerative endodontics. J Endod. 2026; :. doi: 10.1016/j.joen.2026.08.018. PubMed PMID:42628723 .
- Yang, S, Liu, J, Thalakiriyawa, DS, Liu, J, Yang, X, Yiu, CKY et al.. Dental Pulp Stem Cells Transfer Mitochondria via Tunneling Nanotubes to Drive Hypoxic Angiogenesis. J Dent Res. 2026; :220345261473588. doi: 10.1177/00220345261473588. PubMed PMID:42627102 .
- Elsherbini, AM, Ezzat, SK. Therapeutic potential of dental follicle-derived stem cells and gold nanoparticles on osteoarthritic temporomandibular joint in guinea pigs (randomized prospective study). BMC Oral Health. 2026;26 (1):. doi: 10.1186/s12903-026-09529-3. PubMed PMID:42625181 PubMed Central PMC13491649.
- Ernawati, DS, Fatria, AA, Amiruddin, RSDK, Syafira, AA, Viany, A, Putri, SD et al.. Intraglandular injection of amniotic-derived stem cell metabolites enhances submandibular gland regeneration in diabetic male rats. Odontology. 2026; :. doi: 10.1007/s10266-026-01539-5. PubMed PMID:42624977 .
- Alshaibani, DA, Kamadjaja, MJ, Sitalaksmi, RM, Ridwan, RD, Al-Gabri, RS, Ainoosah, S et al.. Effect of hUCMSC-seeded hydroxyapatite-chitosan scaffolds on immunomodulatory cytokine expression during alveolar socket healing: an in vivo study. Odontology. 2026; :. doi: 10.1007/s10266-026-01538-6. PubMed PMID:42624976 .
- Maruoka, H, Hasegawa, T, Hongo, H, Yamamoto, T, Abe, M, Kitakamae-Haraguchi, M et al.. Spatiotemporal distribution of α-smooth muscle actin-positive mesenchymal cells during tooth development and mechanical remodeling of the murine periodontal ligament. Odontology. 2026; :. doi: 10.1007/s10266-026-01541-x. PubMed PMID:42624975 .
- Phothichailert, S, Gyi, KK, Fitri, AR, Zohaib, S, Ijaz, A, Suwittayarak, R et al.. PTEN-mediated regulation of dental mesenchymal stem cell function: A scoping review. Arch Oral Biol. 2026;191 :106717. doi: 10.1016/j.archoralbio.2026.106717. PubMed PMID:42623834 .
- Kordparijaei, E, Ferdosi-Shahandashti, E, Harasani, Z. Innovative Bioengineering Strategies to Enhance Dental Stem Cell Therapeutic Effects in Oncology Treatments. Tissue Eng Part B Rev. 2026; :19373368261469473. doi: 10.1177/19373368261469473. PubMed PMID:42622076 .
- Torres, BS, Foster, C, Abrams, SR, Kerosuo, L. Unveiling the Prevalence and Surgical Burden of Neurocristopathies: A Scoping Review and Statistical Analysis. Res Sq. 2026; :. doi: 10.21203/rs.3.rs-10318477/v1. PubMed PMID:42620502 PubMed Central PMC13484851.
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