Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Sun, M, Xu, C, Wu, R, Yang, Q, Ding, X, Zhao, N et al.. Surface-Engineered Orthopedic Implant to Break the Antimicrobial-Osteogenic Paradox at Biointerfaces in the "Race for the Surface". Adv Mater. 2025; :e2506113. doi: 10.1002/adma.202506113. PubMed PMID:40589270 .
  2. Shrestha, M, Nguyen, TT, Kausar, R, Chaudhary, D, Puspitasari, IF, Jiang, HL et al.. Enhancing hair regrowth using rapamycin-primed mesenchymal stem cell-derived exosomes. Theranostics. 2025;15 (14):6938-6956. doi: 10.7150/thno.107659. PubMed PMID:40585981 PubMed Central PMC12203813.
  3. Sakai, H, Sasaki, JI, Kitagawa, H, Abe, GL, Kohno, T, Funayama, N et al.. Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages. Macromol Biosci. 2025; :e00268. doi: 10.1002/mabi.202500268. PubMed PMID:40582019 .
  4. Tamaru, T, Katayama, R, Momokino, J, Maruoka, Y, Ueda, A, Kanegane, H et al.. Genotype-phenotype correlations in specific granule deficiency: Loss of DNA-binding ability and impaired nuclear localization cause severe manifestations due to the c.655_665del CEBPE variant. Clin Exp Immunol. 2025; :. doi: 10.1093/cei/uxaf045. PubMed PMID:40581342 .
  5. Kim, JS, Qiu, M, Bae, KB, Jang, JH, Kim, WJ, Koh, JT et al.. hDPSC-Derived Secretomes Enhance Odontogenic Differentiation and Suppress Inflammation: A Potential Cell-Free Approach for Regenerative Endodontics. J Endod. 2025; :. doi: 10.1016/j.joen.2025.06.016. PubMed PMID:40581326 .
  6. Doğan, A, Şenkal-Turhan, S, Bulut-Okumuş, E. Neuromesodermal Progenitor Derived Mesenchymal Stem Cells: A new source for osteogenesis and adipogenesis in vitro. Biochimie. 2025; :. doi: 10.1016/j.biochi.2025.06.016. PubMed PMID:40581248 .
  7. Wu, Z, Yang, H, Duan, S, Su, Q, Cheng, R, Hu, T et al.. Histone acetylation facilitates multidirectional pulp repair through Neuregulin-1 mobilization. Stem Cells Transl Med. 2025;14 (7):. doi: 10.1093/stcltm/szaf022. PubMed PMID:40580029 .
  8. Yamada, S, Malkmus, C, Aasebø, E, Mustafa, K, Egusa, H, Volponi, AA et al.. Production and Biobanking of Dental Stem Cells for Clinical Applications in Regenerative Dentistry: Current Practices and Future Perspectives - A Narrative Review. J Dent. 2025; :105934. doi: 10.1016/j.jdent.2025.105934. PubMed PMID:40578781 .
  9. Nováková, S, Hatoková, Z, Danchenko, M, Beke, G, Kľučár, Ľ, Slovinská, L et al.. Proteomic Study Revealed a Distinction Between Human Dermal Fibroblasts and Mesenchymal Stem Cells from Different Sources. Stem Cell Rev Rep. 2025; :. doi: 10.1007/s12015-025-10926-4. PubMed PMID:40576856 .
  10. Samyuktha Aarthi, S, Pandiar, D, Subramanian, R, Krishnan, RP. An in-vitro exploration of the antifibrotic activity of Naringenin: A potential therapeutic agent for oral submucous fibrosis management. J Oral Biol Craniofac Res. 2025;15 (4):849-857. doi: 10.1016/j.jobcr.2025.06.006. PubMed PMID:40575446 PubMed Central PMC12197889.
  11. Kuroda, I, Kawaguchi, T, Chikusa, S, Ishii, S, Aoki, H, Motohashi, T et al.. Allele-Selective Genome Editing of the Human Leukocyte Antigen Locus in Human Dental Pulp Cells Using Zinc Finger Nucleases. Cureus. 2025;17 (5):e84920. doi: 10.7759/cureus.84920. PubMed PMID:40575193 PubMed Central PMC12202062.
  12. Baines, DK, Pawlak-Likus, Z, Tavernaraki, NN, Platania, V, Parati, M, Cheung, TNWW et al.. Effect of Poly-γ-Glutamic Acid Molecular Weight on the Properties of Whey Protein Isolate Hydrogels. Polymers (Basel). 2025;17 (12):. doi: 10.3390/polym17121605. PubMed PMID:40574133 PubMed Central PMC12196781.
  13. Galvani, LD, Bordini, EAF, Soares, DG, Costa, JLSG, Verbicário, JR, Guastaldi, FPS et al.. Aloe Vera as an Adjunct in Endodontic Irrigation: Impact on Dentin Bond Strength and Cytotoxicity. Materials (Basel). 2025;18 (12):. doi: 10.3390/ma18122874. PubMed PMID:40573004 PubMed Central PMC12194964.
  14. Wu, F, Jiang, Z. Long Noncoding RNA MIR4435-2HG is Involved in Osteogenic Differentiation and Inflammation in Human Dental Pulp Stem Cells. Int Dent J. 2025;75 (4):100866. doi: 10.1016/j.identj.2025.100866. PubMed PMID:40570674 .
  15. Chen, C, Yun, Q, Ran, J, Zhou, Z, Zhang, P, Li, R et al.. The Hippo-YAP/β-catenin signaling axis coordinates odontogenic differentiation in dental pulp stem cells: Implications for dentin-pulp regeneration. PLoS One. 2025;20 (6):e0326978. doi: 10.1371/journal.pone.0326978. PubMed PMID:40570025 PubMed Central PMC12200642.
  16. Białomyzy, A, Kotrych, K, Bogacz, A, Podralska, M, Górska, A, Białecki, J et al.. Ozone Therapy and Negative Pressure Wound Therapy in the Treatment of Difficult-to-Heal Wounds in Diabetic Foot Syndrome and Charcot Neuroarthropathy. J Clin Med. 2025;14 (12):. doi: 10.3390/jcm14124017. PubMed PMID:40565762 PubMed Central PMC12194255.
  17. Lwin, HY, Tiskratok, W, Kyawsoewin, M, Manokawinchoke, J, Termkwanchareon, C, Limjeerajarus, N et al.. Shear Stress Regulates Osteogenic Differentiation of Human Dental Pulp Stem Cells via the p38 Pathway. Int J Mol Sci. 2025;26 (12):. doi: 10.3390/ijms26125667. PubMed PMID:40565131 PubMed Central PMC12193168.
  18. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Mechanistic insights into periodontal ligament stem cell-derived exosomes in tissue regeneration. Clin Oral Investig. 2025;29 (7):357. doi: 10.1007/s00784-025-06422-1. PubMed PMID:40562987 PubMed Central PMC12198077.
  19. Chayawatto, S, Kornsuthisopon, C, Linsuwanont, P. The effect of fluocinolone acetonide, ProRoot MTA and their combination on inflammation and odontogenic differentiation of inflamed human dental pulp cells. Clin Oral Investig. 2025;29 (7):358. doi: 10.1007/s00784-025-06380-8. PubMed PMID:40562895 .
  20. Zhang, J, Wang, W, Wang, M, Hai, H, Li, K, Wang, L et al.. Piezoelectric-IL-4 programmed regulation of immuno-microenvironment-induced mesenchymal stem cell recruitment and differentiation for bone regeneration. Ultrason Sonochem. 2025;120 :107431. doi: 10.1016/j.ultsonch.2025.107431. PubMed PMID:40561661 .
  21. Montero-Del-Toro, JA, Serralta-Interian, AA, Nic-Can, GI, Lamas, M, Rivera-Solís, RA, Rodas-Junco, BA et al.. Histone H3 Lysine 9 Acetylation Plays a Role in Adipogenesis of Periodontal Ligament-Derived Stem Cells. Epigenomes. 2025;9 (2):. doi: 10.3390/epigenomes9020015. PubMed PMID:40558826 PubMed Central PMC12192146.
  22. Roato, I, Orrico, C, Meinardi, S, Pedraza, R, Mosca Balma, A, Baima, G et al.. The Pro-Angiogenic Potential of Periodontal Ligament Stem Cells and Dental Pulp Stem Cells: A Comparative Analysis. Cells. 2025;14 (12):. doi: 10.3390/cells14120864. PubMed PMID:40558491 PubMed Central PMC12191286.
  23. Wang, Y, Cao, Y, Fan, Z. Mettl7a alleviated bone loss in osteoporosis mice by targeting the O-GlcNAcylation of Bsp via m6A methylation. Stem Cells Transl Med. 2025;14 (7):. doi: 10.1093/stcltm/szaf024. PubMed PMID:40558384 PubMed Central PMC12188527.
  24. Wang, J, Qu, X, Zhang, Z, Meng, X, Qi, G. Molecular Stress Response of Mitochondria during Electrostimulation Evoking Stem Cell Differentiation Revealed by Fluorescence Imaging Combined with SERS Spectra. ACS Meas Sci Au. 2025;5 (3):294-303. doi: 10.1021/acsmeasuresciau.5c00005. PubMed PMID:40556875 PubMed Central PMC12183591.
  25. Naserkhaki, R, Shokouhian, B, Tahamtani, Y, Khosravi, A, Iravani, S, Zarrabi, A et al.. Revisiting Treatment Strategies: Addressing Epithelial-to-Mesenchymal Transition-Induced Resistance in Hepatocellular Carcinoma. BME Front. 2025;6 :0144. doi: 10.34133/bmef.0144. PubMed PMID:40556662 PubMed Central PMC12187357.
  26. Xu, Z, Zhu, Y, Liu, L, Liu, C, Zhang, Z, Li, M et al.. An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer's disease in rats. Metab Brain Dis. 2025;40 (6):233. doi: 10.1007/s11011-025-01661-3. PubMed PMID:40553395 .
  27. Karaturk, H, Gonen, ZB, Saraymen, R, Gokdemir, NS, Salkin, H. Effects of dental pulp-derived mesenchymal stem cell exosomes produced under hypoxia conditions on osteoarthritic chondrocytes. Connect Tissue Res. 2025; :1-13. doi: 10.1080/03008207.2025.2519064. PubMed PMID:40552715 .
  28. Mujawar, AS, Pandit, V, Shaikh, S, Shaikh, B. Cytotoxicity of chitosan-loaded triple antibiotic paste versus conventional triple antibiotic paste on dental pulp stem cells: An in vitro study. J Conserv Dent Endod. 2025;28 (6):549-553. doi: 10.4103/JCDE.JCDE_219_25. PubMed PMID:40546868 PubMed Central PMC12178552.
  29. Uemura, Y, Yamamoto, M, Ishimura, M, Kanegane, H, Sawada, A, Hirakawa, A et al.. JAK1/2 inhibitor ruxolitinib for the treatment of systemic chronic active Epstein-Barr virus disease: a phase 2 study. Blood Neoplasia. 2025;2 (1):100053. doi: 10.1016/j.bneo.2024.100053. PubMed PMID:40546725 PubMed Central PMC12182833.
  30. Zheng, Y, Li, Y, Wei, Z, Wang, Y, Liu, Y, Liu, F et al.. HUC-MSC-derived exosomal miR-16-5p attenuates inflammation via dual suppression of M1 macrophage polarization and Th1 differentiation. Biochem Biophys Rep. 2025;43 :102078. doi: 10.1016/j.bbrep.2025.102078. PubMed PMID:40546345 PubMed Central PMC12181010.
  31. Sheela, S, AlGhalban, FM, Khalil, KA, Gopinath, VK. The potential of resolvin D2 loaded hydroxyapatite/mineral trioxide aggregate electrospun membranes to downregulate Interleukin 1 beta and tumor necrosis factor alpha in human dental pulp stem cells and macrophages co-cultures. Clin Oral Investig. 2025;29 (7):346. doi: 10.1007/s00784-025-06426-x. PubMed PMID:40542955 .
  32. Seong, KJ, Park, S, Jang, SH, Park, ZY, Jung, JY, Kim, WJ et al.. Dental pulp stem cell secretome inhibits mitophagy-induced hippocampal neural injury during hypoxia. Free Radic Biol Med. 2025;238 :36-51. doi: 10.1016/j.freeradbiomed.2025.06.021. PubMed PMID:40541802 .
  33. Yun, YG, Yeo, D, Tran, TTT, Shin, SJ, Shin, JS, Lim, NK et al.. The characterization of the biological effect of hypoxia-mimetic condition on angiogenic potential in mesenchymal stem cells derived from different origins. Cells Dev. 2025; :204039. doi: 10.1016/j.cdev.2025.204039. PubMed PMID:40541762 .
  34. Ishibashi, A, Ohta, N, Uegaki, Y, Suzuki, H, Fukino, K, Hisatomi, Y et al.. HVJ-E links Apolipoprotein d to antitumor effects. J Immunother Cancer. 2025;13 (6):. doi: 10.1136/jitc-2024-011442. PubMed PMID:40541272 PubMed Central PMC12182123.
  35. Tsilifis, C, Raedler, J, Renke, J, Medinger, M, Laberko, A, Haraldsson, Á et al.. Allogeneic haematopoietic stem cell transplantation for STAT3 hyper-IgE syndrome: a worldwide study. Blood Adv. 2025; :. doi: 10.1182/bloodadvances.2025016158. PubMed PMID:40540800 .
  36. Wang, Z, Joun, J, Song, JH, Koh, JT. Alveolar Bone Mesenchymal Stem Cells Exhibit Osteogenic Potential with Fewer Macrophages. J Bone Metab. 2025;32 (2):83-92. doi: 10.11005/jbm.25.847. PubMed PMID:40537103 PubMed Central PMC12183363.
  37. Irfan, M, Kim, JH, Sreekumar, S, Chung, S. Gene expression profiles identify key factors in inflammatory odontoblastic dental pulp stem cell differentiation via TNFα/C5L2. Front Genet. 2025;16 :1592599. doi: 10.3389/fgene.2025.1592599. PubMed PMID:40534837 PubMed Central PMC12174388.
  38. Schiffmaier, J, Rehling, S, Marnet, K, Borst, A, Trivanović, D, Docheva, D et al.. Establishment of human periodontal ligament cell lines with ALPL mutations to mimic dental aspects of hypophosphatasia. Front Cell Dev Biol. 2025;13 :1572571. doi: 10.3389/fcell.2025.1572571. PubMed PMID:40530336 PubMed Central PMC12170583.
  39. Lancia, L, Mauro, A, Mattei, V, Delle Monache, S, Pulcini, F. Protocol for the generation and analysis of organoids from Dental pulp stem cells (DPSCs). Tissue Cell. 2025;96 :103010. doi: 10.1016/j.tice.2025.103010. PubMed PMID:40526978 .
  40. Cheng, R, Sun, H, Qiao, X, Chen, X. LncRNA XIST facilitates the odontogenic differentiation of dental pulp stem cells via the FUS/ZBTB16. J Appl Oral Sci. 2024;32 :e20230444. doi: 10.1590/1678-7757-2023-0444. PubMed PMID:40525809 .
  41. Srinivasan, S, Ghone, NV. Modulating Proliferation, Migration and Differentiation of Mesenchymal Stem Cells Using Interleukins. Curr Stem Cell Res Ther. 2025;20 (5):546-564. doi: 10.2174/011574888X313750240524115446. PubMed PMID:40525425 .
  42. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Isolation methods of exosomes derived from dental stem cells. Int J Oral Sci. 2025;17 (1):50. doi: 10.1038/s41368-025-00370-y. PubMed PMID:40523888 PubMed Central PMC12170887.
  43. Yue, Z, Gong, W, Chu, H, Li, Y. PTH Promotes Chondrogenesis of Fibrocartilage Stem Cells and Alleviates Temporomandibular Joint Osteoarthritis. Tissue Eng Regen Med. 2025;22 (5):705-718. doi: 10.1007/s13770-025-00723-y. PubMed PMID:40522441 .
  44. Shekatkar, M, Kheur, S, Deshpande, S, Sakhare, S, Sanap, A, Kharat, A et al.. Enhancing angiogenesis through secretomes: Insights from scratch wound assay. J Oral Biol Craniofac Res. 2025;15 (4):789-798. doi: 10.1016/j.jobcr.2025.05.008. PubMed PMID:40520763 PubMed Central PMC12167018.
  45. Anuar Shariff, K, Patera Nugraha, A, Hafedh Mohammed Mohammed, A, Bagus Narmada, I, Gusti Aju Wahju Ardani, I, Faradilla Ramadhani, N et al.. Osteoinductivity performance dicalcium phosphate dihydrate-coated porous β-tricalcium phosphate granules in adipose-derived mesenchymal stem cells. Dent Mater J. 2025; :. doi: 10.4012/dmj.2024-310. PubMed PMID:40518314 .
  46. Zhuang, Z, Han, C, Cai, M, Li, M, Lin, S, Chen, L et al.. The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.026. PubMed PMID:40518112 .
  47. Hodjat, M, Khan, F, Mohammadpour, H, Asadi, N. Restoring impaired osteogenic differentiation of diabetic rat stromal cells using epigenetic inhibitors. Adv Med Sci. 2025;70 (2):266-276. doi: 10.1016/j.advms.2025.06.001. PubMed PMID:40517812 .
  48. Wang, S, Zhuang, D, Xu, Q, Hou, D, Feng, T, Guo, J et al.. Biomaterial-enhanced delivery of stem cell-derived exosomes for skin inflammatory diseases: Mechanisms and therapeutic advances. Int J Biol Macromol. 2025;318 (Pt 3):145213. doi: 10.1016/j.ijbiomac.2025.145213. PubMed PMID:40516725 .
  49. Dong, Q, Zhang, H, Zhang, Q, Fei, X, Ruan, J, He, L et al.. Dimethyloxalylglycine regulates osteogenesis of dental pulp stem cells through PI3K/AKT signaling pathways. Tissue Cell. 2025;96 :103012. doi: 10.1016/j.tice.2025.103012. PubMed PMID:40516134 .
  50. Huang, S, Wu, Y, Zhao, H, Song, K, Liu, Y, Mao, J et al.. Advancements in bone organoids: perspectives on construction methodologies and application strategies. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.011. PubMed PMID:40513657 .
  51. Peng, H, Tan, J, Li, X. Loading curcumin on TiO2nanotubes to improve surface biological activity. Biomed Mater. 2025;20 (4):. doi: 10.1088/1748-605X/ade488. PubMed PMID:40513615 .
  52. Aratikatla, A, Arcot, S, Gupta, M, Gupta, A. Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review. Indian J Orthop. 2025;59 (6):710-719. doi: 10.1007/s43465-024-01275-4. PubMed PMID:40511361 PubMed Central PMC12151939.
  53. Fujii, Y, Yoshida, T, Sato, A, Ikehata, M, Hatori, A, Chikazu, D et al.. Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling. Regen Ther. 2025;30 :100-106. doi: 10.1016/j.reth.2025.05.006. PubMed PMID:40511256 PubMed Central PMC12159295.
  54. Mieszkowska, A, Martocq, L, Koptyug, A, Surmeneva, MA, Surmenev, RA, Naderi, J et al.. Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111514. PubMed PMID:40508757 PubMed Central PMC12157878.
  55. Farjaminejad, R, Farjaminejad, S, Garcia-Godoy, F. Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111475. PubMed PMID:40508718 PubMed Central PMC12157830.
  56. Lai, SY, Lin, SI, Chang, CW, Shen, YR, Mine, Y, Lin, ZC et al.. Comparative Evaluation of Dental Clinical Surface Treatments for Polyetheretherketone with Airborne-Particle Abrasion, Hydrofluoric Acid Etching, and Handheld Nonthermal Plasma Activation on Long-Term Bond Performance. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111448. PubMed PMID:40508691 PubMed Central PMC12157909.
  57. Mosca Balma, A, Pedraza, R, Orrico, C, Meinardi, S, Genova, T, Gautier di Confiengo, G et al.. Poly(ε-Caprolactone)/Sodium Bicarbonate/β-Tricalcium Phosphate Composites: Surface Characterization and Early Biological Response. Materials (Basel). 2025;18 (11):. doi: 10.3390/ma18112600. PubMed PMID:40508598 PubMed Central PMC12155874.
  58. Patel, T, Mešić, J, Meretzki, S, Bronshtein, T, Brlek, P, Kivity, V et al.. Therapeutic Potential and Mechanisms of Mesenchymal Stem Cells in Coronary Artery Disease: Narrative Review. Int J Mol Sci. 2025;26 (11):. doi: 10.3390/ijms26115414. PubMed PMID:40508220 PubMed Central PMC12156323.
  59. Dipalma, G, Marinelli, G, Palumbo, I, Guglielmo, M, Riccaldo, L, Morolla, R et al.. Mesenchymal Stem Cells in Oral and Maxillofacial Surgery: A Systematic Review of Clinical Applications and Regenerative Outcomes. J Clin Med. 2025;14 (11):. doi: 10.3390/jcm14113623. PubMed PMID:40507385 PubMed Central PMC12155250.
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  77. Tian, J, Lou, Y, Li, M, Duan, Y, Liu, H, Chen, C et al.. Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism. Bioact Mater. 2025;51 :179-196. doi: 10.1016/j.bioactmat.2025.04.034. PubMed PMID:40475085 PubMed Central PMC12137177.
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