Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Anuar Shariff, K, Patera Nugraha, A, Hafedh Mohammed Mohammed, A, Bagus Narmada, I, Gusti Aju Wahju Ardani, I, Faradilla Ramadhani, N et al.. Osteoinductivity performance dicalcium phosphate dihydrate-coated porous β-tricalcium phosphate granules in adipose-derived mesenchymal stem cells. Dent Mater J. 2025; :. doi: 10.4012/dmj.2024-310. PubMed PMID:40518314 .
  2. Zhuang, Z, Han, C, Cai, M, Li, M, Lin, S, Chen, L et al.. The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.026. PubMed PMID:40518112 .
  3. Hodjat, M, Khan, F, Mohammadpour, H, Asadi, N. Restoring impaired osteogenic differentiation of diabetic rat stromal cells using epigenetic inhibitors. Adv Med Sci. 2025; :. doi: 10.1016/j.advms.2025.06.001. PubMed PMID:40517812 .
  4. Wang, S, Zhuang, D, Xu, Q, Hou, D, Feng, T, Guo, J et al.. Biomaterial-enhanced delivery of stem cell-derived exosomes for skin inflammatory diseases: Mechanisms and therapeutic advances. Int J Biol Macromol. 2025; :145213. doi: 10.1016/j.ijbiomac.2025.145213. PubMed PMID:40516725 .
  5. Dong, Q, Zhang, H, Zhang, Q, Fei, X, Ruan, J, He, L et al.. Dimethyloxalylglycine regulates osteogenesis of dental pulp stem cells through PI3K/AKT signaling pathways. Tissue Cell. 2025;96 :103012. doi: 10.1016/j.tice.2025.103012. PubMed PMID:40516134 .
  6. Huang, S, Wu, Y, Zhao, H, Song, K, Liu, Y, Mao, J et al.. Advancements in bone organoids: perspectives on construction methodologies and application strategies. J Adv Res. 2025; :. doi: 10.1016/j.jare.2025.06.011. PubMed PMID:40513657 .
  7. Peng, H, Tan, J, Li, X. Loading curcumin on titanium nanotubes to improve surface biological activity. Biomed Mater. 2025; :. doi: 10.1088/1748-605X/ade488. PubMed PMID:40513615 .
  8. Aratikatla, A, Arcot, S, Gupta, M, Gupta, A. Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review. Indian J Orthop. 2025;59 (6):710-719. doi: 10.1007/s43465-024-01275-4. PubMed PMID:40511361 PubMed Central PMC12151939.
  9. Fujii, Y, Yoshida, T, Sato, A, Ikehata, M, Hatori, A, Chikazu, D et al.. Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling. Regen Ther. 2025;30 :100-106. doi: 10.1016/j.reth.2025.05.006. PubMed PMID:40511256 PubMed Central PMC12159295.
  10. Mieszkowska, A, Martocq, L, Koptyug, A, Surmeneva, MA, Surmenev, RA, Naderi, J et al.. Anti-Inflammatory and Osteogenic Effect of Phloroglucinol-Enriched Whey Protein Isolate Fibrillar Coating on Ti-6Al-4V Alloy. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111514. PubMed PMID:40508757 PubMed Central PMC12157878.
  11. Farjaminejad, R, Farjaminejad, S, Garcia-Godoy, F. Regenerative Endodontic Therapies: Harnessing Stem Cells, Scaffolds, and Growth Factors. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111475. PubMed PMID:40508718 PubMed Central PMC12157830.
  12. Lai, SY, Lin, SI, Chang, CW, Shen, YR, Mine, Y, Lin, ZC et al.. Comparative Evaluation of Dental Clinical Surface Treatments for Polyetheretherketone with Airborne-Particle Abrasion, Hydrofluoric Acid Etching, and Handheld Nonthermal Plasma Activation on Long-Term Bond Performance. Polymers (Basel). 2025;17 (11):. doi: 10.3390/polym17111448. PubMed PMID:40508691 PubMed Central PMC12157909.
  13. Mosca Balma, A, Pedraza, R, Orrico, C, Meinardi, S, Genova, T, Gautier di Confiengo, G et al.. Poly(ε-Caprolactone)/Sodium Bicarbonate/β-Tricalcium Phosphate Composites: Surface Characterization and Early Biological Response. Materials (Basel). 2025;18 (11):. doi: 10.3390/ma18112600. PubMed PMID:40508598 PubMed Central PMC12155874.
  14. Patel, T, Mešić, J, Meretzki, S, Bronshtein, T, Brlek, P, Kivity, V et al.. Therapeutic Potential and Mechanisms of Mesenchymal Stem Cells in Coronary Artery Disease: Narrative Review. Int J Mol Sci. 2025;26 (11):. doi: 10.3390/ijms26115414. PubMed PMID:40508220 PubMed Central PMC12156323.
  15. Dipalma, G, Marinelli, G, Palumbo, I, Guglielmo, M, Riccaldo, L, Morolla, R et al.. Mesenchymal Stem Cells in Oral and Maxillofacial Surgery: A Systematic Review of Clinical Applications and Regenerative Outcomes. J Clin Med. 2025;14 (11):. doi: 10.3390/jcm14113623. PubMed PMID:40507385 PubMed Central PMC12155250.
  16. Zhao, Y, He, J, Liang, C, Hong, M, Liao, L, Su, X et al.. G-CSF/laponite/collagen composite inducing stem cells of apical papilla homing for dental pulp regeneration. Dent Mater. 2025; :. doi: 10.1016/j.dental.2025.06.001. PubMed PMID:40506328 .
  17. Yu, JL, Yang, C, Liu, L, Lin, A, Guo, SJ, Tian, WD et al.. Optimal good manufacturing practice-compliant production of dental follicle stem cell sheet and its application in Sprague-Dawley rat periodontitis. World J Stem Cells. 2025;17 (5):104116. doi: 10.4252/wjsc.v17.i5.104116. PubMed PMID:40503360 PubMed Central PMC12149792.
  18. Jiang, YS, Wei, WS, Xie, DT, Guo, G. Circular RNAs inducing the osteogenic differentiation of dental mesenchymal stem cells via microRNA sponging. World J Stem Cells. 2025;17 (5):101638. doi: 10.4252/wjsc.v17.i5.101638. PubMed PMID:40503359 PubMed Central PMC12149794.
  19. Mito, M, Tsuchiya, A, Ishii, S, Tonouchi, T, Furuyama, K, Jinbo, R et al.. Multidirectional therapeutic effects of synthesized HMGB1 peptide on liver cirrhosis in mice. Biochem Biophys Rep. 2025;42 :102061. doi: 10.1016/j.bbrep.2025.102061. PubMed PMID:40503100 PubMed Central PMC12152499.
  20. Vohra, M, Maiti, S, Shah, KK, Raju, L, Nallaswamy, D, Eswaramoorthy, R et al.. Influence of L-arginine on hydroxyapatite-based ovine bone graft - An in vitro evaluation of surface characteristics and cell viability. Dent Res J (Isfahan). 2025;22 :19. doi: 10.4103/drj.drj_263_24. PubMed PMID:40502445 PubMed Central PMC12155389.
  21. Wang, Y, Zhu, L, Liu, H, Jin, S, Wu, X, Wu, T et al.. Prim-O-Glucosylcimifugin Repairs Diabetic Tendon Injury by Rescuing Tendon Stem/Progenitor Cell Hypofunction Through AMPK Pathway Activation. Adv Healthc Mater. 2025; :e2501239. doi: 10.1002/adhm.202501239. PubMed PMID:40500937 .
  22. Pires, RS, Santos, MS, Miguel, F, da Silva, CL, Silva, JC. Electrical Stimulation of Oral Tissue-Derived Stem Cells: Unlocking New Potential for Dental and Periodontal Regeneration. Cells. 2025;14 (11):. doi: 10.3390/cells14110840. PubMed PMID:40498016 PubMed Central PMC12155425.
  23. Ahmad, P, Estrin, N, Farshidfar, N, Zhang, Y, Miron, RJ. Mechanistic insights into dental stem cells-derived exosomes in regenerative endodontics. Int Endod J. 2025; :. doi: 10.1111/iej.14269. PubMed PMID:40497413 .
  24. Zhang, Q, He, P, Shi, S, Xu, Q, Granquist, EJ, Winkelstein, BA et al.. Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration. J Nanobiotechnology. 2025;23 (1):434. doi: 10.1186/s12951-025-03515-7. PubMed PMID:40495198 PubMed Central PMC12150548.
  25. Wang, Z, Wang, M, Luo, Z, Fu, Y, Zhu, X, Li, D et al.. VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation. Int Dent J. 2025;75 (4):100850. doi: 10.1016/j.identj.2025.100850. PubMed PMID:40494210 .
  26. Rajasekar, V, Abdalla, MM, Neelakantan, P, Yiu, CKY. Cellular dynamics and signalling mechanisms in dentine repair: A narrative review. Int Endod J. 2025; :. doi: 10.1111/iej.14261. PubMed PMID:40491185 .
  27. Murugesan, A, Ravi, S, Ekambaram, M, Balakrishnan, S, Indrapriyadharshini, K. Tumor hypoxia and cancer stem cell markers expression in oral squamous cell carcinoma- An Immunohistochemical analysis. Indian J Pathol Microbiol. 2025; :. doi: 10.4103/ijpm.ijpm_174_24. PubMed PMID:40485407 .
  28. Velhal, K, Sah, P, Raut, R, Yamgar, R, Naidu, R, Kalra, P et al.. A novel approach: inclusion complex-capped gold nanoparticles for paclitaxel delivery in triple-negative breast cancer. Med Oncol. 2025;42 (7):243. doi: 10.1007/s12032-025-02805-2. PubMed PMID:40483654 .
  29. Takahashi, G, Maeda, M, Shinozaki, K, Harada, G, Ito, S, Miyaoka, Y et al.. High-throughput robotic isolation of human iPS cell clones reveals frequent homozygous induction of identical genetic manipulations by CRISPR-Cas9. Stem Cell Res Ther. 2025;16 (1):295. doi: 10.1186/s13287-025-04414-2. PubMed PMID:40483517 PubMed Central PMC12145606.
  30. Liang, S, Du, S, Zheng, Y, Xia, D, Zhou, Y. Biodegradable Zn-xY alloys with enhanced osteogenesis and angiogenesis effects for bone implant applications. Acta Biomater. 2025; :. doi: 10.1016/j.actbio.2025.05.048. PubMed PMID:40482983 .
  31. Qin, TX, Zhu, YY, Ng, WH, Ng, SK, Chek, MF, Tang, KD et al.. Adipocytes promote cancer stemness properties in oral squamous cell carcinoma through C3/C3AR axis and sphingolipid metabolism. Cancer Lett. 2025;628 :217848. doi: 10.1016/j.canlet.2025.217848. PubMed PMID:40482908 .
  32. Shan, C, Wang, W, Lu, H, Wang, K, Wang, T, Zhang, Z et al.. A spatially organized Cd24a+/Pax9+ stem cell core governs postnatal tooth establishment. Sci Adv. 2025;11 (23):eadu5653. doi: 10.1126/sciadv.adu5653. PubMed PMID:40479070 PubMed Central PMC12143388.
  33. Tian, J, Lou, Y, Li, M, Duan, Y, Liu, H, Chen, C et al.. Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism. Bioact Mater. 2025;51 :179-196. doi: 10.1016/j.bioactmat.2025.04.034. PubMed PMID:40475085 PubMed Central PMC12137177.
  34. Li, Y, Wang, X, Weng, S, Xia, C, Meng, X, Yang, C et al.. Cardiomyocyte pyroptosis inhibited by dental pulp-derived mesenchymal stem cells via the miR-19a-3p/IRF-8/MAPK pathway in ischemia-reperfusion. Chin Med J (Engl). 2025; :. doi: 10.1097/CM9.0000000000003623. PubMed PMID:40474332 .
  35. Al-Masoody, AH, Asadi, N, Mohammadpour, H, Hodjat, M, Kashi, TSJ. Effects of combining hyaluronic acid hydrogel with injectable platelet rich fibrin on apical papilla stem cells proliferation and differentiation. BMC Oral Health. 2025;25 (1):913. doi: 10.1186/s12903-025-06236-3. PubMed PMID:40474136 PubMed Central PMC12142928.
  36. Saini, M, Paliwal, J, Sharma, V, Gupta, N, Meena, KK, Singhal, P et al.. Influence of PEEK surface modification with titanium for improving osseointegration: an in vitro study. Sci Rep. 2025;15 (1):19801. doi: 10.1038/s41598-025-05214-7. PubMed PMID:40473857 PubMed Central PMC12141525.
  37. Ramesh, P, Pena, R, Morrissey, JM, Moskwa, N, Tubbesing, K, Zhang, X et al.. Cryoelectrospun elastin-alginate scaffolds as potential cell delivery vehicles for mesenchymal stromal cell therapy. Sci Rep. 2025;15 (1):19847. doi: 10.1038/s41598-025-03822-x. PubMed PMID:40473688 PubMed Central PMC12141519.
  38. Wang, X, Dong, C, Lamichhane, B, Thapa, S, Zhang, Y, Gupta, S et al.. Din Oversees Mesenchymal Stem Cell Homeostasis in Mouse Incisors. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-6568233/v1. PubMed PMID:40470223 PubMed Central PMC12136219.
  39. Lu, X, Liu, Y, Dai, L, Cheng, B, Li, Y. EGFL6 Promotes Angiogenesis and Odontogenesis in Pulp Regeneration via MAPK Signaling Pathways. Curr Stem Cell Res Ther. 2025; :. doi: 10.2174/011574888X362657250528171158. PubMed PMID:40468928 .
  40. Chen, S, Huang, G, Guo, Z, Guo, Z, Cao, C, Zhao, G et al.. Tumor-associated Schwann cells promote salivary adenoid cystic carcinoma stem-like reprogramming via IGF2/IGF1R induced histone H3 lysine 18 lactylation. Cancer Lett. 2025;628 :217847. doi: 10.1016/j.canlet.2025.217847. PubMed PMID:40466903 .
  41. Tangrodchanapong, T, Jiso, A, Changkaew, P, Khachonkham, S, Thongsuk, A, Chodchavanchai, T et al.. Radioprotective effects of asiaticoside and asiatic acid in neural stem cells derived from human stem cells from apical papilla through increasing dose-reduction factor and their lowering effects on SH-SY5Y cell viability. PLoS One. 2025;20 (6):e0325480. doi: 10.1371/journal.pone.0325480. PubMed PMID:40465752 PubMed Central PMC12136317.
  42. Wang, Y, Wang, H, Tan, J, Cao, Z, Wang, Q, Wang, H et al.. Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases. Mol Biomed. 2025;6 (1):34. doi: 10.1186/s43556-025-00277-4. PubMed PMID:40465163 PubMed Central PMC12137892.
  43. Hu, J, Zhao, L, Liu, X, Xu, L, Zhao, H. Exploring research hotspots and trends in periodontal regeneration from 2000 to 2023: a bibliometric analysis. Saudi Dent J. 2025;37 (4-6):15. doi: 10.1007/s44445-025-00023-0. PubMed PMID:40464866 PubMed Central PMC12137857.
  44. Shao, J, Xu, W, Tao, N, Du, H, He, Z, Wang, L et al.. Hepatocyte Growth Factor-Modified Dental Pulp Stem Cells Potentially Regulate Novel Renal Fibrosis-Associated Gene via PI3K/AKT/GSK3β Pathway to Alleviate Renal Fibrosis. Hum Gene Ther. 2025; :. doi: 10.1089/hum.2025.044. PubMed PMID:40462757 .
  45. Di, T, Wang, L, Feng, C, Xu, J, Shao, B, Cheng, B et al.. ECM remodeling by PDGFRβ+ dental pulp stem cells drives angiogenesis and pulp regeneration via integrin signaling. Stem Cell Res Ther. 2025;16 (1):283. doi: 10.1186/s13287-025-04382-7. PubMed PMID:40462244 PubMed Central PMC12135250.
  46. Jiang, Y, Zhang, Z, Ren, K, Zhou, S, Qiao, Y, Huang, W et al.. Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations. J Biol Eng. 2025;19 (1):52. doi: 10.1186/s13036-025-00524-w. PubMed PMID:40462207 PubMed Central PMC12135596.
  47. Khokhani, P, Warmink, K, Kruyt, M, Weinans, H, Gawlitta, D. Mixtures of PRR Ligands Partly Mimic the Immunomodulatory Response of γi Staphylococcus aureus, Enhancing Osteogenic Differentiation of Human Mesenchymal Stromal Cells. Stem Cells Int. 2025;2025 :1445520. doi: 10.1155/sci/1445520. PubMed PMID:40458752 PubMed Central PMC12127128.
  48. Wang, B, Kong, Y, Dong, H, Lai, F, Guo, Z, Lin, L et al.. Exosomal circ_0003057 promotes osteo/odontogenic differentiation of hDPSCs by binding with EIF4A3 through upregulated parental gene ANKH. Int Endod J. 2025; :. doi: 10.1111/iej.14262. PubMed PMID:40457889 .
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  50. Gultekin, SE, von Brandenstein, M, Baris, E, Atak Secen, I, Arslan Bozdag, L, Goebel, H et al.. The Role of Vimentin 3 in Ameloblastomas: A Novel Tumor Biomarker. Oral Dis. 2025; :. doi: 10.1111/odi.15396. PubMed PMID:40457691 .
  51. Alauti, RY, Mukhtar, AH, Alasqah, M, Alenazi, MH, Gufran, K. Efficacy of Different Concentrations of Melatonin on Cultured Human Periodontal Ligament Stem Cells. Med Sci Monit Basic Res. 2025;31 :e948551. doi: 10.12659/MSMBR.948551. PubMed PMID:40457609 PubMed Central PMC12144917.
  52. Lin, L, Dong, H, Lai, F, Zhang, J, Wang, B, Lv, X et al.. circ_0002456/FUS interaction inhibits NF-κB signaling to attenuate DNA damage and inflammatory responses in hDPSCs. Stem Cell Res Ther. 2025;16 (1):276. doi: 10.1186/s13287-025-04391-6. PubMed PMID:40457486 PubMed Central PMC12131344.
  53. Liu, Y, Liu, Y, Ye, Z, Wang, X, Li, J, Mei, PL et al.. Application of dental pulp stem cell-conditioned medium combined with deep cryopreservation of autologous cranial flaps. Stem Cell Res Ther. 2025;16 (1):272. doi: 10.1186/s13287-025-04407-1. PubMed PMID:40457321 PubMed Central PMC12131630.
  54. Zhang, Y, Si, C, Yang, C, Wang, A, Yu, B. Porphyromonas gingivalis induced DNA oxidative stress damage by iron overload to deplete CTCF expression and prevent osteogenic differentiation of periodontal ligament stem cells. J Mol Histol. 2025;56 (3):182. doi: 10.1007/s10735-025-10467-7. PubMed PMID:40455363 .
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