Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Yoo, SH, Heo, SC, Bae, JS, Lee, JH, Knowles, JC, Kim, HW et al.. Intranasal delivery systems for traumatic brain injury: Advancements and perspectives. J Tissue Eng. 2025;16 :20417314251372373. doi: 10.1177/20417314251372373. PubMed PMID:40955355 PubMed Central PMC12433564.
  2. Li, W, Liu, Q, Chen, S, Zhi, M, Yang, P, Zhang, Y et al.. Salidroside Improves Periodontitis by Mitigating Inflammatory Reactions and Enhancing Osteogenic Differentiation of Human Periodontal Ligament Stem Cells. Drug Des Devel Ther. 2025;19 :8097-8114. doi: 10.2147/DDDT.S530311. PubMed PMID:40955307 PubMed Central PMC12433638.
  3. Liu, H, Jiang, Y, Sun, C, Guo, J, Li, M. Macrophage Efferocytosis Controls Tissue Repair via Mitochondrial Dynamics in Diabetic Periodontitis. J Periodontal Res. 2025; :. doi: 10.1111/jre.70030. PubMed PMID:40952029 .
  4. Stanley, M, Rajula, MAPB, Shankar, PLR, Rao, KS, Sairam, A, Jeyakumaran, S et al.. Evaluation of the impact of curcumin concentrations on the viability of human periodontal ligament cells: An in vitro study. J Indian Soc Periodontol. 2025;29 (2):147-152. doi: 10.4103/jisp.jisp_461_24. PubMed PMID:40951748 PubMed Central PMC12425268.
  5. Liu, L, Behera, TR, Wang, QJ, Shen, QQ. Advances in mesenchymal stem cell therapy for lupus nephritis. World J Stem Cells. 2025;17 (8):104930. doi: 10.4252/wjsc.v17.i8.104930. PubMed PMID:40951714 PubMed Central PMC12432543.
  6. Wu, Y, He, M, Li, C, Shang, W, Hu, J, Liu, B et al.. Zirconia/dental pulp stem cell composite scaffolds repair osteogenic defect via regulating macrophages. Front Bioeng Biotechnol. 2025;13 :1632000. doi: 10.3389/fbioe.2025.1632000. PubMed PMID:40948971 PubMed Central PMC12426132.
  7. Ferraz, DC, Pinto, JC, Letra, A, Silva, RM, de Souza, LC, Guerreiro-Tanomaru, JM et al.. Physicochemical properties and periodontal ligament stem cell response to NeoMTA 2. Clin Oral Investig. 2025;29 (10):449. doi: 10.1007/s00784-025-06538-4. PubMed PMID:40947454 .
  8. Kobrock, A, Patrício, D, Matos, B, Zarzuela, E, Muñoz, J, Howl, J et al.. Identification of the PP1 interactome in human dental pulp: Insights for regenerative strategies. Cell Signal. 2025; :112132. doi: 10.1016/j.cellsig.2025.112132. PubMed PMID:40946946 .
  9. Bai, H, Li, J, Tu, Y, Bao, C. LepR+ Fibroblasts Activated by BMP Signaling Promote Bone Resorption in Developmental Odontogenic Cysts. Lab Invest. 2025; :104239. doi: 10.1016/j.labinv.2025.104239. PubMed PMID:40946915 .
  10. Reiniche, L, Faure, M, Leveque, M, Orelle, C, Ziverec, A, Farges, JC et al.. In silico and in vitro characterization of GH12, an innovative peptide for dental pulp regeneration. J Dent. 2025; :106105. doi: 10.1016/j.jdent.2025.106105. PubMed PMID:40945681 .
  11. Haridy, MF, Shamel, M, Khalil, RA, Mohamed, AR, Fouda, H, Ahmed, HS et al.. Influence of different finishing and polishing protocols of composite CAD CAM blocks on surface roughness and biological response of gingival mesenchymal stem cells. Odontology. 2025; :. doi: 10.1007/s10266-025-01190-6. PubMed PMID:40944824 .
  12. Fernandes, MRU, Teti, G, Gatta, V, Longhin, A, Aranha, ACC, Falconi, M et al.. Impact of Photobiomodulation on the Pro-Osteogenic Activity of Dental Pulp Mesenchymal Stem/Stromal Cells. Int J Mol Sci. 2025;26 (17):. doi: 10.3390/ijms26178174. PubMed PMID:40943099 PubMed Central PMC12428731.
  13. Bashir, A, Bashir, M, Rizwan, MA. Exosomes from Stem Cells: A Future Alternative to Whole-Cell Therapy in Heart Failure. Cardiovasc Drugs Ther. 2025; :. doi: 10.1007/s10557-025-07777-z. PubMed PMID:40938550 .
  14. Shioda, S, Kasai, F, Ozawa, M, Ohtani, A, Iemura, M, Watanabe, K et al.. Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines. Microbiologyopen. 2025;14 (5):e70061. doi: 10.1002/mbo3.70061. PubMed PMID:40936104 PubMed Central PMC12425812.
  15. Arai, Y, Tsutsumi-Arai, C, English, JD, Ono, N, Ono, W. Mesenchymal Stem Cells in Socket Healing and MRONJ. Orthod Craniofac Res. 2025; :. doi: 10.1111/ocr.70025. PubMed PMID:40932045 .
  16. Qiao, LR, Chang, Z, Li, CH, Hang, JT, Wu, XJ, Xiao, YH et al.. A transition of dynamic rheological responses of single cells: from fluid-like to solid-like. Biophys J. 2025; :. doi: 10.1016/j.bpj.2025.09.010. PubMed PMID:40931528 .
  17. Madarieta, I, Luzuriaga, J, Salvador-Moya, J, Pardo-Rodríguez, B, García-Gallastegui, P, García-Urkia, N et al.. Generation of humanized bone for disease modeling using porcine adipose tissue-derived extracellular matrix scaffolds and human dental pulp stem cells. Methods Cell Biol. 2025;197 :59-76. doi: 10.1016/bs.mcb.2025.06.003. PubMed PMID:40930704 .
  18. Lamarque, GCC, Leme, RD, Almeida Junior, LA, Lucisano, MP, Bombonato-Prado, KF, Segato, RAB et al.. Effects triggered by tumor necrosis factor-α in immortalized murine dental pulp and pre-osteoblastic cells. Braz Oral Res. 2025;39 :e087. doi: 10.1590/1807-3107bor-2025.vol39.087. PubMed PMID:40929406 PubMed Central PMC12419187.
  19. Hatoková, Z, Baďurová, B, Kertys, M, Žideková, N, Evinová, A, Kotúľová, L et al.. Biological and Metabolomic Characterization of Human Dermal Fibroblasts and Mesenchymal Stem Cells Derived from Human Dental Pulp and Adipose Tissue: a Pilot Comparative Study. Stem Cell Rev Rep. 2025; :. doi: 10.1007/s12015-025-10970-0. PubMed PMID:40928693 .
  20. Chen, C, Gao, Z, Li, Y, Zhou, T, Zheng, H, Jiang, S et al.. Sustained Mg/Sr ion delivery from injectable silk fibroin hydrogels drives SCAP osteogenic differentiation. iScience. 2025;28 (9):113353. doi: 10.1016/j.isci.2025.113353. PubMed PMID:40927678 PubMed Central PMC12414828.
  21. Qi, L, Liang, X, Qin, Z, Gao, H, Zhang, Y, Wang, Y et al.. Effect of Oral Pathogens Associated With Pulpitis and Apical Periodontitis on Odontogenic Mesenchymal Stem Cells. Stem Cells Int. 2025;2025 :5523197. doi: 10.1155/sci/5523197. PubMed PMID:40922724 PubMed Central PMC12414624.
  22. Li, T, Dai, Z, Wang, Z, Wang, M, Cai, C, Zhu, X et al.. LncRNA TP53TG1 promotes the growth and osteo/dentinogenic differentiation of dental pulp stem cells by activating the Smad3 and JNK1/2 pathway. In Vitro Cell Dev Biol Anim. 2025; :. doi: 10.1007/s11626-025-01086-3. PubMed PMID:40921962 .
  23. Bagio, DA, Margono, A, Julianto, I, Ricardo, S, Alinda, SD. Enhancing the Odontogenic Potential of Human Dental Pulp Stem Cells via Platelet-Rich Plasma Exosomes through Modulation of TGF-β1 and Dentin Sialophosphoprotein. Eur J Dent. 2025; :. doi: 10.1055/s-0045-1811556. PubMed PMID:40921191 .
  24. Dunne, OM, Roe, NAM, Mousnier, A, Martin, SL, Sergeant, GP, About, I et al.. Neuroinflammatory Consequences of Rhinovirus Infection in Human Epithelial and Neuronal Models. Lung. 2025;203 (1):93. doi: 10.1007/s00408-025-00846-y. PubMed PMID:40916026 PubMed Central PMC12414851.
  25. Pignatti, E, Jiang, L, Shah, MS, Karpurapu, A, Miao, J, Liu, Y et al.. CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development. Dev Biol. 2025; :. doi: 10.1016/j.ydbio.2025.09.004. PubMed PMID:40915528 .
  26. Liu, X, Tian, H, Wang, D, Nie, F, Chen, Y, Wang, Y et al.. Ligand-metal charge transfer-enabled copper-gallate nanozyme rescue oxidative stressed reparative cells for inflammatory dental tissue regeneration. Biomaterials. 2025;326 :123672. doi: 10.1016/j.biomaterials.2025.123672. PubMed PMID:40911959 .
  27. Baghaei, S, Azarpira, N, Paknahad, M, Amani, AM, Dortaj, H, Koohpeyma, F et al.. Synergistic Angio-Osteogenic Effects of Copper-Releasing 3D Biocomposite Scaffolds: A Step Toward Vascularized Bone Regeneration. Res Sq. 2025; :. doi: 10.21203/rs.3.rs-7159849/v1. PubMed PMID:40909782 PubMed Central PMC12408024.
  28. Jiao, M, Shuai, T, Zhao, Z, Wu, Y, Yu, L, Sun, J et al.. Categories, applications, and potential of stem cells in bone regeneration: an overview. Front Med (Lausanne). 2025;12 :1606100. doi: 10.3389/fmed.2025.1606100. PubMed PMID:40909447 PubMed Central PMC12406871.
  29. Pang, P, Liu, Y, Song, H, Ye, Z, Zhou, H, Zhang, R et al.. Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing. Diabetes. 2025; :. doi: 10.2337/db24-0686. PubMed PMID:40906538 .
  30. Krishnakumar, S, Nandini, VV, Thirunavukarasu, K, Chinnathambi, U, Venkatesh, KV. Cissus quadrangularis mediated biogenic synthesis of silver-nanohydroxyapatite-mesoporous silica nanocomposite, characterization, and cytotoxicity evaluation on dental pulp stem cells. Discov Nano. 2025;20 (1):150. doi: 10.1186/s11671-025-04336-1. PubMed PMID:40906305 PubMed Central PMC12411362.
  31. Wang, L, Liu, M, Yu, H, Sun, L, Xia, Y, Sun, S et al.. Sodium alendronate doped chitosan based micro hybrid scaffold enhances in situ biomimetic mineralization and promotes endogenous bone regeneration. Int J Biol Macromol. 2025;327 (Pt 2):147289. doi: 10.1016/j.ijbiomac.2025.147289. PubMed PMID:40902753 .
  32. Wang, W, Ma, A, Zhai, C, Lan, W, Liu, Z, Yang, Z et al.. Bisphenol A and Di-n-butyl phthalate disrupt bone homeostasis bidirectionally via CD36-mediated BMSCs autophagy inhibition and exosome-promoted osteoclastogenesis. J Hazard Mater. 2025;497 :139703. doi: 10.1016/j.jhazmat.2025.139703. PubMed PMID:40902528 .
  33. Matsui-Chujo, Y, Hatori, A, Nakano, M, Kanno, Y, Ikeguchi, R, Aoyama, T et al.. Facial Nerve Regeneration in Immunodeficient Rats Using a Bio 3D Conduit Fabricated From Human Dental Pulp Stem Cells. Stem Cells Int. 2025;2025 :1923945. doi: 10.1155/sci/1923945. PubMed PMID:40900738 PubMed Central PMC12401602.
  34. Mattei, V, Santilli, F, Pulcini, F, Fabrizi, J, Lancia, L, Santacroce, C et al.. Validated methods for isolation and qualification of mesenchymal stromal/stem cells from different sources. J Transl Med. 2025;23 (1):975. doi: 10.1186/s12967-025-06972-8. PubMed PMID:40898279 PubMed Central PMC12403454.
  35. Zhang, H, Feng, T, Lin, J, Yahaya, BH. Bibliometric-driven research on chemoresistance in breast cancer: knowledge mapping, hotspot evolution, and emerging insights (1994-2024). Discov Oncol. 2025;16 (1):1676. doi: 10.1007/s12672-025-03542-8. PubMed PMID:40897893 PubMed Central PMC12405092.
  36. Yu, L, Zhou, Z, Chen, M, Li, X. Metformin as a protective supplement enhances survival and stemness maintenance of human dental pulp stem cells during cryopreservation. Cryobiology. 2025;120 :105300. doi: 10.1016/j.cryobiol.2025.105300. PubMed PMID:40896913 .
  37. Husain, A, Ahmad, F, Pandey, S, Upadhyay, TK, Kang, S, Choi, M et al.. Progenitor cells, microglia, and non-coding RNAs: Orchestrators of glioblastoma pathogenesis and therapeutic resistance. Noncoding RNA Res. 2025;15 :85-99. doi: 10.1016/j.ncrna.2025.07.007. PubMed PMID:40896358 PubMed Central PMC12391438.
  38. Chatterjee, I, Agrawal, P, Sinha, Y, Majee, N, Bansal, S. In Vitro Response of Dental Pulp Stem Cells to Calcium Silicate-Based Cements: A Systematic Review and Meta-Analysis of Preclinical Evidence. Cureus. 2025;17 (7):e88990. doi: 10.7759/cureus.88990. PubMed PMID:40895876 PubMed Central PMC12395108.
  39. Thongsuk, A, Seemaung, P, Phanthong, P, Janebodin, K, Ruangsawasdi, N, Gonmanee, T et al.. Neuronal differentiation of human dental pulp stem cells induced by co-treatment of ergothioneine. PLoS One. 2025;20 (9):e0331120. doi: 10.1371/journal.pone.0331120. PubMed PMID:40892799 PubMed Central PMC12404401.
  40. Germain, P, Grillon, C, Nguyen, KV. A narrative review of potential therapies for the treatment of myocardial tissue in relation to heart failure. Nucleosides Nucleotides Nucleic Acids. 2025; :1-29. doi: 10.1080/15257770.2025.2550969. PubMed PMID:40889110 .
  41. Pourheidary, H, Tehranchi, M, Taleghani, F, Hodjat, M, Pourhajibagher, M, Hakimiha, N et al.. Evaluation of the combined effects of photobiomodulation therapy and periodontal ligament stem cell-derived exosomes on the proliferation and migration of human gingival fibroblasts: An in vitro study. J Dent. 2025;162 :106053. doi: 10.1016/j.jdent.2025.106053. PubMed PMID:40850464 .
  42. Leveque, M, Reiniche, L, Faure, M, Orelle, C, Farges, JC, Richert, R et al.. Antimicrobial GH12-fibrin hydrogel for dental pulp regeneration: An in vitro study. Dent Mater. 2025; :. doi: 10.1016/j.dental.2025.08.010. PubMed PMID:40883160 .
  43. Abuarqoub, D, Albarghouthi, R, AbuOun, M, Aslam, N, Alasmar, A, Mutahar, M et al.. Photobiomodulation using low-level laser therapy (LLLT) enhanced the osteogenesis of dental pulp stem cells. J Photochem Photobiol B. 2025;271 :113247. doi: 10.1016/j.jphotobiol.2025.113247. PubMed PMID:40882418 .
  44. Mohd Arizam, DN, Nordin, F, Ahmad, A, Ahmad Amin Noordin, KB. Integrin signaling pathways in mesenchymal stem cells. Stem Cell Res Ther. 2025;16 (1):472. doi: 10.1186/s13287-025-04608-8. PubMed PMID:40877985 PubMed Central PMC12395929.
  45. Kamal, D, Rady, D, El Moshy, S, Radwan, IA, Ahmed, NEB, Wadan, AS et al.. Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects. Sci Rep. 2025;15 (1):31722. doi: 10.1038/s41598-025-15924-7. PubMed PMID:40877384 PubMed Central PMC12394624.
  46. Mosca Balma, A, Pedraza, R, Roato, I, Orrico, C, Meinardi, S, Bertinetti, S et al.. Early Biological Response to Poly(ε-caprolactone) PCL-Bioactive Glass Composites Obtained by 3D Printing as Bone Substitutes. Polymers (Basel). 2025;17 (16):. doi: 10.3390/polym17162229. PubMed PMID:40871175 PubMed Central PMC12389235.
  47. Payão, TS, Pellegrini, V, Morari, J, Gonçalves, GMS, de Godoy, MCX, Gambero, A et al.. The Secretome of Human Deciduous Tooth-Derived Mesenchymal Stem Cells Enhances In Vitro Wound Healing and Modulates Inflammation. Pharmaceutics. 2025;17 (8):. doi: 10.3390/pharmaceutics17080961. PubMed PMID:40870984 PubMed Central PMC12388939.
  48. Bogovska-Gigova, R, Ishkitiev, N, Miteva, M, Hristov, K. Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth-An In Vitro Study. Materials (Basel). 2025;18 (16):. doi: 10.3390/ma18163863. PubMed PMID:40870180 PubMed Central PMC12387468.
  49. Milosevic Markovic, M, Anicic, B, Lazarevic, M, Jaksic Karisik, M, Mitic, D, Milovanovic, B et al.. Cytotoxic Effects of Thymus serpyllum L. and Mentha × piperita L. Essential Oils on Basal Cell Carcinoma-An In Vitro Study. Life (Basel). 2025;15 (8):. doi: 10.3390/life15081296. PubMed PMID:40868944 PubMed Central PMC12387631.
  50. Elango, J, Zamora-Ledezma, C. Rheological, Structural, and Biological Trade-Offs in Bioink Design for 3D Bioprinting. Gels. 2025;11 (8):. doi: 10.3390/gels11080659. PubMed PMID:40868789 PubMed Central PMC12385449.
  51. Luo, Q, Gao, K, Li, Y, Zhang, Z, Chen, S, Zhou, J et al.. Osteogenesis Activity and Porosity Effect of Biodegradable Mg-Ga Alloys Barrier Membrane for Guided Bone Regeneration: An in Vitro and in Vivo Study in Rabbits. Biomedicines. 2025;13 (8):. doi: 10.3390/biomedicines13081940. PubMed PMID:40868193 PubMed Central PMC12383429.
  52. Zhang, Z, Upadhyay, S, Luong, C, Du, W, Hu, JK. Lats1/2 Differentially Modulate the Proliferative State of Dental Epithelial Progenitors and Ameloblasts in the Murine Incisor. Orthod Craniofac Res. 2025; :. doi: 10.1111/ocr.70019. PubMed PMID:40878823 .
  53. Sharma, D, Gupta, S, Koshy, G, Sharma, VK, Kamboj, M, Hooda, A et al.. Expression profile of cancer stem cell markers SOX2, OCT4 & NANOG in salivary gland malignancies: A systematic review. Indian J Med Res. 2025;161 (6):636-646. doi: 10.25259/IJMR_724_2024. PubMed PMID:40878342 .
  54. Etemadi, A, Fathizadeh, P, Chiniforush, N. The impact of photobiomodulation therapy on the survival and differentiation of periodontal ligament mesenchymal stem cells exposed to zoledronic acid. Sci Rep. 2025;15 (1):31731. doi: 10.1038/s41598-025-17466-4. PubMed PMID:40877474 PubMed Central PMC12394465.
  55. Eberliköse, H, Yaylacı, S, Kaçaroğlu, D, Ceylan, H. Multifunctional peptide nanofiber coatings enhance bone regeneration on xenograft materials. Sci Rep. 2025;15 (1):31541. doi: 10.1038/s41598-025-15743-w. PubMed PMID:40866399 PubMed Central PMC12391473.
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  58. Hsu, WC, Cha, TY, Yao, YC, Kang, CM, Wu, SH, Mine, Y et al.. Promoting Surface Energy and Osteoblast Viability on Zirconia Implant Abutments Through Glass-Ceramic Spray Deposition Technology. J Funct Biomater. 2025;16 (8):. doi: 10.3390/jfb16080288. PubMed PMID:40863308 PubMed Central PMC12387143.
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