Dental Stem Cells

The Mesenchymal Stem Cells found in Teeth are now the most researched Stem Cells in the Scientific Literature.

Dental Stem Cell Research

  1. Nakashima, M, Yoshihashi, N, Tanaka, H, Iohara, K. Regeneration of the pulp-dentin complex in mature teeth using autologous demineralized dentin matrix and dental pulp stem cells: two case reports. BMC Oral Health. 2025; :. doi: 10.1186/s12903-025-07578-8. PubMed PMID:41430218 .
  2. Che, J, Qiu, Z, Hou, H, Li, Y, He, L, Sun, J et al.. SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity. J Tissue Eng Regen Med. 2025;2025 :6659059. doi: 10.1155/term/6659059. PubMed PMID:41427031 PubMed Central PMC12714168.
  3. Tatsumi, H, Okawa, H, Vinaikosol, N, Moribayashi, A, Kayashima, H, Yatani, H et al.. Spheroid size-induced apoptosis enhances osteogenic differentiation of iPS cells. J Biosci Bioeng. 2025; :. doi: 10.1016/j.jbiosc.2025.11.010. PubMed PMID:41423395 .
  4. Nakayasu, A, Sakaguchi, K, Namba, M, Inaba, A, Kanamaru, S, Aihara, E et al.. Generation and characterization of taste organoids from primates. Biochem Biophys Res Commun. 2025;796 :153154. doi: 10.1016/j.bbrc.2025.153154. PubMed PMID:41421220 .
  5. Jian, L, Nan, F, Zhang, Y, Jiang, Y, Sun, M, Yang, W et al.. Dual-targeting nanotherapy disrupts fungal-bacterial synergy to reprogram inflammatory microenvironments in periodontitis. Biomaterials. 2025;329 :123923. doi: 10.1016/j.biomaterials.2025.123923. PubMed PMID:41420961 .
  6. Salem, EM, Rizk, H, Abouelela, YS, Prince, A, Tohamy, AF, Lasheen, NA et al.. Retraction Note: Regenerative potentials of bone marrow mesenchymal stem cells derived exosomes or its combination with zinc in recovery of degenerated circumvallate papilla following surgical bilateral transection of glossopharyngeal nerve in rats. BMC Oral Health. 2025;25 (1):1918. doi: 10.1186/s12903-025-07383-3. PubMed PMID:41419912 PubMed Central PMC12717747.
  7. Lee, C, Miyamoto, Y, Chen, W, Kim, E, Chang, I, Kang, MK et al.. Immunohistological characterization of minced dental pulp transplant in an ectopic mouse model. J Endod. 2025; :. doi: 10.1016/j.joen.2025.11.017. PubMed PMID:41419056 .
  8. Kim, S, Seong, SB, Seong, KJ, Mun, BR, Choi, WS, Jung, JY et al.. Alpha-Bisabolol Alleviates LPS-reduced Hippocampal Neurogenesis and Cognitive Function by Anti-inflammatory action via Downregulating MAPK and NF-κB Signaling in Mice. Brain Res Bull. 2025; :111690. doi: 10.1016/j.brainresbull.2025.111690. PubMed PMID:41412265 .
  9. GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators. Global burden of lower respiratory infections and aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. Lancet Infect Dis. 2025; :. doi: 10.1016/S1473-3099(25)00689-9. PubMed PMID:41412141 .
  10. Ma, L, Zhang, Y, Song, Z, Wang, P, Liang, L, Chen, M et al.. miR-423-5p-enriched small extracellular vesicles drive periodontal regeneration via Sfrp2+ cell expansion. Bioact Mater. 2026;58 :19-32. doi: 10.1016/j.bioactmat.2025.11.026. PubMed PMID:41403869 PubMed Central PMC12703869.
  11. Kim, HB, Sung, CK. Synergistic Effects of Near-Infrared Photobiomodulation and Allogeneic Fibrin Serum on Osteogenic Differentiation of Human Dental Pulp Stem Cells. J Biophotonics. 2025; :e202500340. doi: 10.1002/jbio.202500340. PubMed PMID:41403260 .
  12. Huang, Z, Julaiti, M, Su, X, Chen, X, Luan, Q. Differential Expression of Paired Related Homeobox 1 in Gingival Tissues and Its Association With Site-Specific Wound Healing. J Craniofac Surg. 2025; :. doi: 10.1097/SCS.0000000000012303. PubMed PMID:41401458 .
  13. Jeong, HJ, Zhu, E, Chen, B, Chen, NK, Kang, MS, Lee, CH et al.. Delayed Onset of Physiological Loading Promotes Maturation of Avascular Meniscus Healing. J Orthop Res. 2026;44 (1):e70111. doi: 10.1002/jor.70111. PubMed PMID:41400091 .
  14. Kim, JE, Park, S, Lim, JW, Jang, KJ, Park, B, Kim, HB et al.. Enhanced Osteogenic and Neurogenic Differentiation of Dental Pulp Stem Cells by Micro-Current Stimulation and Chitosan-Poly(Ethylene Glycol) Blended Calcium Phosphate Cement. ACS Appl Bio Mater. 2025; :. doi: 10.1021/acsabm.5c01573. PubMed PMID:41400006 .
  15. Huang, S, Zhang, Q, Zhang, M, Liu, X, Liu, M, Sun, J et al.. Stem Cells From the Apical Papilla Cultured in Spheroids Spontaneously Differentiate Into Odontoblasts via N-Cadherin Downregulation. FASEB J. 2025;39 (24):e71350. doi: 10.1096/fj.202503113R. PubMed PMID:41399894 .
  16. Turbatmath, K, Delphine Priscilla Antony, S, Subramanian, R. Biocompatibility and odontogenic potential of an indigenous apitherapeutic pulp capping agent: A comparative in vitro analysis using hDPSCs. J Oral Biol Craniofac Res. 2026;16 (1):113-119. doi: 10.1016/j.jobcr.2025.11.008. PubMed PMID:41399451 PubMed Central PMC12702004.
  17. Manickam Natarajan, P, Karuppan Perumal, MK, Rama Varma, S, Thomas, S, Odeh, R, Rajan Renuka, R et al.. SFXN1 expression analysis in oral squamous cell carcinoma and its association with the PI3K-AKT-mTOR pathway and immune cell infiltration. J Oral Biol Craniofac Res. 2026;16 (1):120-128. doi: 10.1016/j.jobcr.2025.11.010. PubMed PMID:41399448 PubMed Central PMC12702013.
  18. Hwang, TI, Peng, PW, Chi, MS, Chou, KY, Tsai, TF, Ho, CY et al.. Thrombospondin-4 drives lymphangiogenesis through cooperation with VEGF-C in human bladder cancer. Int J Med Sci. 2026;23 (1):204-215. doi: 10.7150/ijms.122895. PubMed PMID:41399375 PubMed Central PMC12702125.
  19. Sun, S, Zhu, B, Wang, H. Investigating the therapeutic mechanisms of dental pulp stem cells in Parkinson's disease: A bioinformatics-based multi-omics analysis. Biochem Biophys Res Commun. 2025;795 :153127. doi: 10.1016/j.bbrc.2025.153127. PubMed PMID:41397323 .
  20. Liang, C, Wu, S, Huang, Z, Wu, Z, Chen, S, Li, F et al.. Harnessing Oxidized Alginate Microgels for Rapid and Self-Assembling Dental Tissue Organogenesis In Vitro and In Vivo. Small Sci. 2025;5 (12):e202500053. doi: 10.1002/smsc.202500053. PubMed PMID:41395504 PubMed Central PMC12697820.
  21. P, S, Mansukhbhai, TV, Bhatt, PS, Bhatnagar, S, Laddha, R, Desai, R et al.. Clinical evaluation of 3D printing and tissue engineering in craniofacial reconstruction: A prospective observational study. Bioinformation. 2025;21 (8):2909-2913. doi: 10.6026/973206300212909. PubMed PMID:41393393 PubMed Central PMC12697462.
  22. Jiang, Y, She, J, Wang, Z, Zhu, Y, Liu, Y, Zhang, P et al.. Apoptotic vesicles rectify senile bone-fat imbalance by activating Thy1-ERK-TAZ axis. J Nanobiotechnology. 2025; :. doi: 10.1186/s12951-025-03928-4. PubMed PMID:41390652 .
  23. Yi, L, Gao, J, Yin, Z, Huang, C, Sun, T, Gao, G et al.. Synergistic Antibacterial Remineralization: A Bioprocessing-Inspired Single-Step Nanoparticle-Induced Liquid Precursor Strategy for Functional Dentin Repair. ACS Nano. 2025;19 (50):42419-42435. doi: 10.1021/acsnano.5c14982. PubMed PMID:41384600 .
  24. Desai, PK, Hiwalkar, SM, Kim, HJ, Shin, J, Lee, HS, Jun, HW et al.. Innovations in Bioactive Materials for Dental Pulp Vitality Preservation in Children and Adolescents. Appl Sci (Basel). 2025;15 (9):. doi: 10.3390/app15094699. PubMed PMID:41383262 PubMed Central PMC12692128.
  25. Zhang, W, Zhou, Y, Ye, L, Huang, C, Wang, Y. Long non-coding RNA SNHG6 promotes odontoblastic differentiation of human dental pulp stem cells via the PI3K/Akt/mTOR pathway. Differentiation. 2025;147 :100927. doi: 10.1016/j.diff.2025.100927. PubMed PMID:41380536 .
  26. Basina, VP, Zadiriev, II, Mironov, AV, Vasilyev, AV, Nechay, AE, Goldshtein, DV et al.. [Cytocompatibility of hydroxyapatite coating for titanium implants, applied by radio-frequency magnetron sputtering at low pressures in an inert gas atmosphere]. Stomatologiia (Mosk). 2025;104 (6. Vyp. 2):32-37. doi: 10.17116/stomat202510406232. PubMed PMID:41379408 .
  27. Zhou, G, Yee, MJ, Huh, JT, Safina, I, Chang, WS, Koch, A et al.. Hydrogels Derived from Native Decellularized Perichondrium for Chondrocyte Differentiation and Temporomandibular Joint Repair. ACS Appl Mater Interfaces. 2025; :. doi: 10.1021/acsami.5c18997. PubMed PMID:41378855 .
  28. Shah, MS, Kondo, T, Sundarabupathi, M, Samaranayake, LP, Jamal, M, Egusa, H et al.. Unveiling the dental cellular landscape: A comprehensive review of single-cell RNA sequencing in human dental tissues. Jpn Dent Sci Rev. 2025;61 :301-316. doi: 10.1016/j.jdsr.2025.11.004. PubMed PMID:41377691 PubMed Central PMC12686620.
  29. Mouzzam, AM, Ahmed, A, Aamir, A, Sharma, G, Sarwath, S, D'Moss, J et al.. Stem cell therapy: a paradigm shift in reversing type 1 diabetes mellitus. Ann Med Surg (Lond). 2025;87 (12):8556-8562. doi: 10.1097/MS9.0000000000004147. PubMed PMID:41377288 PubMed Central PMC12689004.
  30. Huang, G, Liu, A, Hu, Y, Yang, R, Dai, Z, Meng, W et al.. Paris polyphylla var. yunnanensis Leaf-Derived Extracellular Vesicle-Like Particles Enhance Periodontal Regeneration. Biomater Res. 2025;29 :0291. doi: 10.34133/bmr.0291. PubMed PMID:41376817 PubMed Central PMC12688648.
  31. Marini, L, Tel, A, Zeppieri, M, Michelutti, L, Robiony, M, Gagliano, C et al.. Possible Diagnostic and Therapeutic Applications of Bioprinting for Bone Regeneration in Maxillofacial Surgery. Diagnostics (Basel). 2025;15 (23):. doi: 10.3390/diagnostics15232978. PubMed PMID:41374359 PubMed Central PMC12691056.
  32. Ahmad Shuhaimi, NA, Abdullah, D, Yazid, F, Ng, SL, Mahamad Apandi, NI, Abdul Ghani, NA et al.. Dentinogenic Effect of BMP-7 on Wharton's Jelly Mesenchymal Stem Cells Cultured in Decellularized Dental Pulp. Int J Mol Sci. 2025;26 (23):. doi: 10.3390/ijms262311760. PubMed PMID:41373906 PubMed Central PMC12693673.
  33. Sa'adah, N, Diyatri, I, Aljunaid, MA, Adriansyah, AA, Qaid, HR, Labib, R et al.. SHED-Secretome Gel Promotes Early Alveolar Bone Healing via Osteoblast-Osteoclast Modulation. Braz Dent J. 2025;36 :e256808. doi: 10.1590/0103-644020256808. PubMed PMID:41370475 PubMed Central PMC12696812.
  34. Jones, RS, Garcia, R, Mutreja, I, Kumar, D. Tissue Biocompatibility and Antimicrobial Properties of Sympathomimetic Nasal Solutions for Potential Use in Dental Pulpal Management. Clin Exp Dent Res. 2025;11 (6):e70259. doi: 10.1002/cre2.70259. PubMed PMID:41369231 PubMed Central PMC12690621.
  35. Schäfer, J, Kleszczynski, K, Schäfer, E. Melatonin and the Dental Pulp: A Scoping Review. Int Endod J. 2025; :. doi: 10.1111/iej.70081. PubMed PMID:41363554 .
  36. Fuchioka, Y, Ozeki, N, Koga, H, Nakamura, T, Nakagawa, Y, Amemiya, M et al.. 3D-MRI evaluation of cartilage thickness changes and their location in the patellofemoral joint after open wedge high tibial osteotomy for knee osteoarthritis: A retrospective cohort study. PLoS One. 2025;20 (12):e0333961. doi: 10.1371/journal.pone.0333961. PubMed PMID:41359622 PubMed Central PMC12685179.
  37. Liu, W, Yang, YY, Shi, ZJ. Post-translational modifications in the oral microenvironment: Stem cell regulation from periodontal regeneration to oral cancer therapy. World J Stem Cells. 2025;17 (11):112702. doi: 10.4252/wjsc.v17.i11.112702. PubMed PMID:41356377 PubMed Central PMC12679265.
  38. Daneshvar, A, MomeniAmjadi, A, Azadi, A, Baniameri, S, Kadkhodazadeh, M. Therapeutic potential of dental mesenchymal stem cells versus mesenchymal stem cells from other sources: a systematic review of animal studies. BMC Oral Health. 2025; :. doi: 10.1186/s12903-025-07100-0. PubMed PMID:41354918 .
  39. Zhang, Q, Huang, S, Liu, X, Zhang, M, Sun, J, Liu, M et al.. Lumican from DESC spheroids enhances odontoblastic differentiation of SCAPs. Stem Cell Res Ther. 2025; :. doi: 10.1186/s13287-025-04849-7. PubMed PMID:41354828 .
  40. Sahadi, BO, Mendes Soares, IP, Gifford, C, Anselmi, C, Hebling, J, Giannini, M et al.. Transdentinal effects of flavonoid-based primers applied to caries-affected dentin on pulp cells. Clin Oral Investig. 2025;30 (1):1. doi: 10.1007/s00784-025-06693-8. PubMed PMID:41354703 PubMed Central PMC12682911.
  41. Mottaghi, M, Jafari, F, Nejati, M, Farshad, F, Khorshidi Asl, Z, Azmoudeh, F et al.. Mitochondrial DNA mutations in head and neck squamous cell carcinoma: a systematic review and meta-analysis. BMC Cancer. 2025; :. doi: 10.1186/s12885-025-15386-0. PubMed PMID:41353392 .
  42. Neves, LBM, Lima, BC, Coutinho de Mello, R, Baldessarini, BL, Peres, RV. Intra-articular therapies for synovial joint dysfunction: a comprehensive integrative review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2025; :. doi: 10.1016/j.oooo.2025.10.026. PubMed PMID:41352996 .
  43. Chen, Y, Hu, M, Lee, YL, Chen, L, Lin, S, Li, X et al.. Progress and Perspectives in Allogeneic Cell-Based Pulp Regeneration. Int Endod J. 2025; :. doi: 10.1111/iej.70080. PubMed PMID:41351292 .
  44. Li, A, Zhong, J, Zhang, X, Yang, X, Ruan, Y, Huang, Y et al.. Photobiomodulation-pretreated dental follicle stem cells with enhanced osteogenic function improve alveolar bone regeneration. BMC Oral Health. 2025;25 (1):1874. doi: 10.1186/s12903-025-07224-3. PubMed PMID:41345589 PubMed Central PMC12679786.
  45. Ren, Q, Rong, X, Liu, T, Zhang, Z, Zhang, W, Liu, H et al.. Glucocorticoid impairs angiogenesis-dependent osteogenesis by downregulating EphB4 in endothelial cells. Biochem Pharmacol. 2025;244 :117586. doi: 10.1016/j.bcp.2025.117586. PubMed PMID:41344513 .
  46. Pan, L, Yang, Y, Jia, X, Zhao, R, Wang, Y, Guan, X et al.. proBDNF-SorCS2 Axis Suppresses Osteogenesis and Augments Inflammation of Human Periodontal Ligament Stem Cells in Inflammatory Conditions. Int Dent J. 2025;76 (1):109294. doi: 10.1016/j.identj.2025.109294. PubMed PMID:41343965 .
  47. Balasubramanian, HP, Suresh, N, Koteeswaran, V, Natanasabapathy, V. Resolvin E1 incorporated carboxymethyl chitosan scaffold accelerates repair of dental pulp stem cells under inflammatory conditions: a laboratory investigation. Restor Dent Endod. 2025;50 (4):e40. doi: 10.5395/rde.2025.50.e40. PubMed PMID:41342210 PubMed Central PMC12707568.
  48. De Francesco, F, Zingaretti, N, Quaglia, D, Moro, G, Pin, AD, Cavaleri, MP et al.. Stemness and clinical performance of water-jet technology: A translational study in breast reconstruction. JPRAS Open. 2025;46 :750-769. doi: 10.1016/j.jpra.2025.10.010. PubMed PMID:41341966 PubMed Central PMC12670530.
  49. Yang, K, Yuan, S, Wang, Y, Lin, A, Huo, F, Jin, Z et al.. Comparative analysis of dental-derived stem cells and alternative stem cell sources: properties and regenerative functions. Front Bioeng Biotechnol. 2025;13 :1717849. doi: 10.3389/fbioe.2025.1717849. PubMed PMID:41341098 PubMed Central PMC12669115.
  50. Subramanya, A, Mata, S, Narkedamalli, R, Belle, VS, Dhanushkodi, A, Duncan, HF et al.. Comparing the Bioactive Effects of Ethylenediaminetetraacetic Acid and Maleic Acid on TGF-β1 Release From Dentine and Dental Pulp Stem Cell Activity. Int Endod J. 2025; :. doi: 10.1111/iej.70075. PubMed PMID:41340595 .
  51. Kim, HS, Shin, TH. Canine and feline mesenchymal stem cells: an integrative review of direct comparative studies by species and tissue source. J Vet Sci. 2025;26 (6):e78. doi: 10.4142/jvs.25163. PubMed PMID:41331998 PubMed Central PMC12703926.
  52. Riksen, NP, Netea, MG, Ait-Oufella, H, Chavakis, T, Hajishengallis, G. Trained immunity in cardiovascular disease. Eur Heart J. 2025; :. doi: 10.1093/eurheartj/ehaf982. PubMed PMID:41330410 .
  53. Pragadesh, G, Srinivasan, D, Abishek, CB, Sujathadevi, BK. Evaluation of Antimicrobial Efficacy and Cytotoxicity of Phytoextract from Leucas aspera as a Root Canal Irrigant in Primary Tooth: In Vitro Study. Int J Clin Pediatr Dent. 2025;18 (11):1378-1384. doi: 10.5005/jp-journals-10005-3308. PubMed PMID:41328382 PubMed Central PMC12658424.
  54. Zhang, Q, Chen, H, Cun, J, Liu, Q, Wang, H, Jiang, L et al.. A simple and standardized method supports efficient derivation of clinical-grade human embryonic stem cells under feeder- and xeno-free conditions. Stem Cell Res Ther. 2025; :. doi: 10.1186/s13287-025-04831-3. PubMed PMID:41327340 .
  55. Zekušić, M, Skoko, M, Vukušić, K, Ledinski, M, Mihica, MB, Blažević, D et al.. Deep-freezing and decontamination strategy for a large autologous bone graft with presentation of the osteogenic potential of resident osteoblasts. Stem Cell Res Ther. 2025; :. doi: 10.1186/s13287-025-04839-9. PubMed PMID:41327281 .
  56. Dabkeviciute, GM, Kriauciunas, A. Exosomes as Central Mediators of Host-Pathogen Interactions in Periodontitis: A Systematic Literature Review. Cureus. 2025;17 (10):e95609. doi: 10.7759/cureus.95609. PubMed PMID:41322905 PubMed Central PMC12659857.
  57. Mahmoudi Anzabi, R, Shenasa, N, Jafarian, A, Davodpour, AH, Zareanshahraki, M, Ghasemirad, M et al.. Enhancing Osteogenesis in Dental Implants: ZNF710-AS1 and miR-146a-5p in Smad Signaling Pathway Activation. Int J Mol Cell Med. 2025;14 (3):964-975. doi: 10.22088/IJMCM.BUMS.14.3.964. PubMed PMID:41321965 PubMed Central PMC12664691.
  58. Ravi, R, Arumuganainar, D. Biogenic synthesis of copper oxide nanoparticles using Alpinia calcarata extract promotes osteoblasts differentiation: An In vitro study. J Oral Biol Craniofac Res. 2026;16 (1):66-72. doi: 10.1016/j.jobcr.2025.11.007. PubMed PMID:41321768 PubMed Central PMC12663638.
  59. Shariff, KA, Nugraha, AP, Mohammed, AHM, Narmada, IB, Ardani, IGAW, Ramadhani, NF et al.. Erratum to: Osteoinductivity performance dicalcium phosphate dihydrate-coated porous β-tricalcium phosphate granules in adipose-derived mesenchymal stem cells. Dent Mater J. 2025;44 (6):716. doi: 10.4012/dmj.2024-310-e. PubMed PMID:41320300 .
  60. de Souza, JR, Mendes Soares, IP, Anselmi, C, Sikder, P, Hebling, J, Borges, ALS et al.. Biodegradable and osteoconductive sodium alginate-gelatin/amorphous magnesium phosphate 3D-printed scaffolds for craniofacial bone regeneration. J Mech Behav Biomed Mater. 2026;174 :107284. doi: 10.1016/j.jmbbm.2025.107284. PubMed PMID:41317696 .
  61. Seong, KJ, Lee, SW, Lee, JH, Ko, HM, Nam, TK, Kim, TY et al.. Epigallocatechin-3-gallate Restores X-irradiation-Induced Impairments in Cognitive Function and Hippocampal Neurogenesis by Suppressing the TLR4-NOX3/4 and ROS-NF-κB Pathways in Microglia. Mol Neurobiol. 2025;63 (1):220. doi: 10.1007/s12035-025-05473-5. PubMed PMID:41317232 .
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