Most people would like to know more about Stem Cells in general, so we put together some of the key points for you here. If you're already a Pro, please proceed to the next section.
Stem cells are defined as precursor or progenitor cells that have the potential to differentiate (mature) into a wide variety of tissue. Dental pulp was recently found to contain adult stem cells, (minimizing any political or ethical issues as seen with embryonic stem cells), and through some dedicated research, are showing amazing potential for tissue engineering applications and treating several degenerative conditions.
In many tissues, stem cells serve as a type of internal repair system, dividing and maturing to replenish tissues that have been damaged or destroyed by injuries or illnesses.
The role of stem cells play in human biology:
Stem cells have the amazing potential to develop into many different cell types in the body during early life and growth. In addition, in many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell.
Stem cells can be divided into two generic groups:
Although often categorized as either embryonic or adult, they actually represent a continuum of cell types that eventually transform into our "end-product" tissue.
Stem cells are classified by their ability to differentiate into different cell types. These classifications are:
Totipotent - the ability of the cell to differentiate into all cell types. Examples include the first few cells after the division of the zygote.
Pluripotent - the ability of the cell to differentiate into almost all cell types. Examples include embryonic stem cells.
Multipotent - the ability of the cell to differentiate into a closely related family of cells . Examples include Hematopoietic and Mesenchymal .
Oligopotent - the ability of the cell to differentiate into a few cells. Examples include myleoid stem cells.
Unipotent - the ability of the cell to differentiate into only one cell type. Examples are muscle stem cells.
Your child’s teeth are a valuable source of stem cells. And the stem cells harvested from our children’s teeth are capable of amazing things. These ‘master cells’ are the basis for creating (and repairing) our entire body from head to toe…
...And the cells harvested from baby teeth are at their optimum because they are young, vibrant, healthy, and full of functionality. By storing your child’s best stem cells now, you can access can them in the future to potentially help your child and your family from numerous diseases and age-related therapies in development.
Plus: Your own stem cells are the best stem cells. They’re unique to you and highly valuable because at some point soon people will be using their own stem cells as the natural way to combat many health conditions.
Dental pulp is a rich source of stem cells — this soft living tissue contains mesenchymal stem cells (MSCs) that can differentiate into a broad range of different cell types, giving them a wider range of potential applications than most other cell types.
The ideal time to harvest MSCs from dental pulp is when our children lose their baby (deciduous) teeth. This can happen through natural loss or extraction making it the only non-invasive method of collecting stem cells.
Plus, stem cells harvested from the dental pulp within teeth have many advantages over other types of stem cells. They are not limited to the amount collected from the tooth because they can be expanded within a laboratory or medical facility.
A small mass of connective tissue, blood vessels, nerves, and stem cells located in a chamber within the dentin layer of a tooth (the pulp chamber is found in the crown and the root of the tooth).
The stem cells found in dental pulp are a non-controversial adult stem cell known as a mesenchymal stem cell. Mesenchymal stem cells can differentiate or "mature into" many different cell types including; osteoblasts (bone cells), chondrocytes (cells that make up cartilage), myocytes (muscle cells), adipocytes (fat cells), neurons and recently described beta cells (cells found in the pancreas that synthesize insulin).
This multipotent potential makes these cells an excellent candidate for "regenerative medicine" and tissue engineering applications.
With all the emerging potential in tissue engineering applications using mesenchymal stem cells, a child's loose tooth, extracted wisdom teeth, extracted adult teeth and pulpectomy can provide first-rate mesenchymal stem cells that can be used in the future for cellular-therapy based applications. Mesenchymal stem cells have shown amazing promise in the potential treatment of Parkinson's and Alzheimer's disease, Type I diabetes, heart attack, stroke, Multiple Sclerosis, ALS, spinal injury and several others.
In the past, extracted teeth and related material has been viewed as medical waste and discarded, resulting in the loss of this potential life-saving resource. Now you can save these cells through OOTHY's Dental Pulp Stem Cell Banking Program, so that you may have access to them in the future.
Imagine a world where we can create living, functional tissue in an effort to repair or replace tissue or organ function lost due to age, disease, damage, or genetic defects. Dental pulp stem cells hold the potential of possibly regenerating damaged tissues and organs in the body by stimulating organs to heal themselves.
The technology within dental pulp stem cells allow scientists to grow tissues and organs in the laboratory and safely implant them when the body cannot heal itself. This is no longer science fiction; it is becoming a reality and dental pulp stem cells may prove to be an important factor in this reality.
Tapping Into The Potential Of Dental Pulp Stem Cells
In the near future, stem cells from dental pulp may provide an effective treatment option for these debilitating disorders. But that's not all. It seems that use of stem cells will used to optimize wellness and prevent the onset of major health issues altogether.
The stem cells from dental pulp may be one of the most promising cell-therapies in the future. Those who preserve dental pulp stem cells do so, to feel at ease, knowing that those cells may have future uses that are extremely valuable.
Hundreds of clinical trials and research show great promise for the use of dental stem cells for treating a variety of health and age-related conditions, including but not limited to:
In addition, there are several ongoing studies to determine other potential clinical applications of these cells.
The research related to stem cells could eventually lead to therapy that could be used in treating diseases that affects nearly 128 millions of Americans.
At this time, MSCs from dental pulp stem cells are primarily being used in laboratory settings. Time will tell how these cells will be used in regenerative applications because MSCs from Teeth, Bone Marrow, Blood and other sources are being explored in more than 600 clinical trials worldwide. *Search results obtained from ClinicalTrials.gov using terms “mesenchymal stem cell” OR “mesenchymal stem cells.”
The most amazing work with stem cells right now is utilizing them for preventative medicine and to improve overall health, wellness and quality of life. It's no longer about treating conditions, it's about preventing terrible diseases and conditions all together. For those that store their own cells, these new Cellular Therapies and Regenerative Medicine advancements can pave the way to a future of Health Independence.
The concept behind cellular therapies is to use one's own stem cells to re-populate specific cells that may be defective or dead.
There are several disorders that require the transplant of new cells to replace dead or damaged cells.
The requirements to treat these disorders are genetically matched stem cells. That is why it is beneficial to bank one's own stem cells, since they are an exact genetic match for the individual.
The amazing thing about most stem cells is their ability to hone in on the site of damage. Most stem cells can be administered systemically (intravenous) and they will migrate to the site of injury. Once there, the stem cells will receive chemical "communications" from the cells of the damaged tissue which will cause the stem cells to differentiate into the cells of the damaged tissue to repair said tissue.
Regenerative Medicine is an emerging field involving stem cell therapy.
Regenerative Medicine employs methods to restore the function of damaged tissue and organs. The four main aspects in regenerative medicine are:
Since scientists have shown tremendous potential for dental pulp stem cells in clinical applications, OOTHY has developed procedures for the safe extraction, processing and cryopreservation of these cells, for you, to be used in potential future clinical applications. A process we call Dental Pulp 2.0
Once you enroll in the Dental Pulp Banking Program, you will receive a Collection Kit with the instructions.
The tooth can be collected at home or at your dental provider. But it is important not to wait for the tooth/teeth to fall out. If the tooth falls out, there hasn't been a blood supply to the tissue and therefore, the tissue and stem cells may have a decrease in viability.
The tooth should still have a blood supply, meaning the tooth should bleed when removed. If the tooth has been dangling for days, it is most likely not a candidate for viable stem cells. In general, for the stem cells to be viable, the tooth must have at least a third of the root intact.
Once removed, the tooth must immediately be placed in the OOTHY collection bottle to maintain tissue viability and shipped overnight to our laboratory using the prepaid FedEx label and envelope provided with your collection kit.
If the tooth is being extracted by a dentist, simply bring the kit with you and they will follow the directions included in the collection kit. If there are any questions, your dentist's staff can call us at (844) MY-OOTHY. Our phone number is also on the collection bottle.
When a client is enrolled in the service, the client receives a Dental Pulp Collection Kit with the required elements for the collection of the tooth/teeth. The Kit must be stored in a safe place, at room temperature, until the dental appointment. The dentist will be provided instructions in the kit for the procurement of the tooth/teeth.
Once the procurement is complete, the tooth/teeth are sent to our laboratory for processing and cryogenic storage.
The sample must remain at room temperature and must not be refrigerated. Once received at our laboratory, the processing and cryopreservation process begins.
Once the dentist has extracted the tooth/teeth, he will place it into the collection bottle provided in the Kit.
The collection bottle contains a solution that will help maintain the tissue viability until the tooth/teeth arrive at our Processing and Cryopreservation Laboratory.
Once the collection kit arrives at our laboratory, the stem cell technicians will review all the paperwork, assign a unique identification number, and place all of your information into our secure database.
The technician will then take the bottle to our sterile processing area and examine the tooth.
Once the tooth passes our initial examination and has been deemed acceptable for processing, the technician will begin the stem cell extraction procedure.
OOTHY is committed to excellence in cell processing and cryogenically storing your dental pulp stem cells. Using state-of-the-art equipment and highly qualified, laboratory personnel, we ensure the highest quality standard is upheld thus providing the best possible service for our clients.
Our highly qualified laboratory director, who has overseen tens of thousands of processed stem cell units, supervises our laboratory. The laboratory technicians are highly experienced in processing and storing stem cell samples.
Our clients can rest assure that their child's processed dental pulp stem cells will be stored under proper temperatures at all times. Our cryogenic storage devices are video and alarm monitored and backed up by our reliable generators and back up nitrogen tanks in the facility.
Your tooth/teeth should be shipped to our facility immediately after the collection has taken place. All the necessary materials (all the paperwork, medical history and tooth/teeth) needed for the processing of your tooth/teeth will arrive at our laboratory under strict quality-controlled conditions in order to safeguard the dental pulp stem cells.
We process our clients' dental stem cells using a highly validated, proprietary processing procedure developed by our scientists at OOTHY and approved by the FDA.
An important aspect in maintaining viability of the Dental Pulp Stem Cells throughout the processing and cryopreservation is controlling the rate of freezing and the subsequent sustained cryogenic temperature of the cells once they are in cryogenic storage.
Our laboratory uses a staged freezing process that ensures the cell's future viability. Once the cells are brought to the optimum temperature, they are placed in a continuously monitored cryogenic freezer where they are held until required for use.
TODD R. FLOWER PhD
Laboratory & Research Director
The OOTHY Collection Kit contains everything you need to protect, preserve and return your child's tooth to our laboratory as soon as it comes out. Price includes collection kit, stem cell processing, confirming validity for medical use, and cryogenic storage.
Simply select the storage option of 20, 40 or 60 Years below to complete your order and receive your OOTHY kit by FedEx.
Our team is here to help you. Please call us with any questions or chat with us on Facebook Messenger below.
12 Monthly Payments
12 Monthly Payments
12 Monthly Payments
For more information and pricing, please call use at (844) MY-OOTHY.
We are available Monday - Friday, 9am - 5pm EST.
Why choose OOTHY?
With more than 15 years of experience, our laboratory uses state-of-the-art equipment and highly qualified personnel for processing and storing stem cells. We ensure the highest quality standards are upheld, thus providing the best possible service for our clients. Our highly qualified laboratory director has overseen tens of thousands of processed cord blood, adipose and dental pulp units, and has also supervised the release of a large number of units for transplant procedures. The laboratory technicians are highly experienced in processing and storing stem cell tissue samples.
What are the costs?
We offer 3 different storage options: Insurance, Regenerative and Longevity. Please see pricing tab.
If I banked my child's cord blood, should I also bank their dental stem cells?
Stem cells from cord blood are used in the treatment of childhood diseases such as leukemia, sickle cell anemia, and lymphoma, to help replenish the patient’s blood supply with healthy new cells. Dental Stem Cells may have the potential to be transformed into other cells including cardiac, muscle, bone, cartilage, nerve, and fat tissue.
How many teeth should I bank?
Because of the uncertainty of how many cells will be needed in the future, and the multiple regenerative uses that will be available, storing multiple teeth is the best idea. The good news is, it is possible to use the tissue from one tooth more than once. Of course, this will depend on the original sample size and the intended medical use.
You can send up to four of your child's teeth at the same time at no additional cost. This is typically the case with Wisdom teeth extractions. Otherwise, the majority of people send one tooth at a time.
Can I give OOTHY as a gift?
Absolutely! What better gift than their future health independence. When checking out, please indicate where you would like the collection kit mailed.
What are researchers currently studying?
Hundreds of clinical trials show great promise for the use of dental stem cells for treating a variety of health and age-related conditions, but at this time, MSCs from dental pulp stem cells are primarily being used in laboratory settings.
Time will tell how these cells will be used in regenerative applications because MSCs from Teeth, Bone Marrow, Blood and other sources are being explored in more than 2000 clinical trials worldwide. Every day researchers are learning more about treating conditions like:
*Search results obtained from ClinicalTrials.gov using terms “mesenchymal stem cell” OR “mesenchymal stem cells.”
Can I store just one child's tooth for the whole family?
No. Each family member has different cells, therefore they will not be an immunological match (unless they are identical twins). Each child should have their own stem cells banked.
Why should I store my child’s stem cells now?
There are many reasons why storing your child’s Dental Stem Cells early in life is important.
By storing teeth that are coming out in a non-invasive manner, you are avoiding painful or intrusive procedures in the future.
Secondly, it’s best to bank your child’s teeth when they are as young as possible because the quality and quantity of the stem cells are superior. Storing your child’s stem cells is easy and could be a possible life-saving resource for them later in life. In addition to defending against terrible diseases, a more likely use will be to take advantage of the many emerging personalized cellular therapies to improve wellness, immunity and prevent health problems before they start.
How do I get started?
Getting started is easy. Once you choose a plan that works best for you, the OOTHY Dental Pulp Collection kit will be mailed out immediately. Follow the instructions in the kit. Please note, the sample must remain at room temperature and not be refrigerated. The collection bottle contains a solution that will help maintain the tissue viability until the tooth arrives at our laboratory.
My child's tooth is loose, can I collect the tooth at home?
Yes. But, it’s important the tooth has a blood supply, meaning the tooth should bleed when removed. If the tooth has been dangling for days, it is most likely not a candidate for viable stem cells. In order for the stem cells to be viable, the tooth must have at least a third of the root intact. The tooth must immediately be placed in the collection bottle to maintain tissue viability and shipped using the prepaid FedEx label and envelope provided with your collection kit.
My dentist will be extracting the tooth, what do I need to tell them?
First, make sure to bring the collection kit with you. The process is simple, and directions are included in the collection kit. Once the dentist has extracted the tooth/teeth, they will place them in the glass collection bottle. FedEx will pick up the kit for overnight shipping back to our laboratory. If there are any questions, your dentist's staff can call us at (844) MY-OOTHY. Our phone number is also on the collection bottle.
What are the best teeth to store?
Baby teeth, wisdom teeth or teeth that just need to be removed for various orthodontic purposes. The best rule of thumb is the younger the stem cells, the better they are!
What if there are no viable cells in my child’s tooth?
This is not common, but if a loose tooth is not removed promptly or shipped to our lab right away, this can affect the integrity of the cells. The key components to maximize cell viability is Time, Temperature and Pressure. Time: Remove a loose tooth quickly and insert it into the glass tooth collection bottle immediately. Temperature: Keep the tooth at room temperature. Pressure: Avoid exposure to high or low-pressure environments that can put extra stress on the tooth.
In the event we do not get a valid sample, we will process another tooth for you at no extra charge. If you don’t have another tooth to send us, we will refund all of your money less $100.
What happens once the stem cell kit is received at the lab for processing?
We follow the regulatory consideration for human cells/ tissue-based products on “minimal manipulation.” As per the FDA “Processing that alters the original characteristics of the HCT/P, raises increased safety and effectiveness concerns for the HCT/P because there would be less basis on which to predict product’s function after transplantation.” Culturing the cells, or performing an enzymatic digestion to isolate the cells from the tissue does not fall under the minimal manipulation guideline.
What about the Tooth Fairy?
The Tooth Fairy actually works with OOTHY! She will provide a certificate stating your child's tooth will be safely stored for their future use. Your child can use this certificate in the place of their lost tooth.
How long can stem cells be stored?
Research indicates that stem cells can be stored cryogenically for an indefinite period of time.
What security systems are in place to protect my child's information and storage?
Our laboratory is FDA registered and inspected. We are HIPAA compliant, and each specimen is assigned two unique identification numbers. Our cryogenic storage devices are connected to a video-monitored alarm system, and are also backed up by our reliable generators and back up nitrogen tanks to ensure your stem cells are safe and secure. Our clients can rest assured that their stem cells will be stored under proper temperatures at all times.
In addition to our own quality assurance and security protocols, we are also located less than one mile from the United States Department of Defense Southern Command Center.
Is Dental Stem Cell banking covered by insurance?
Not at this time. It could be paid for using a Health Savings Account.
What do I do if I need access to the stem cells?
Please contact us and our laboratory team will work with you and your healthcare provider to properly process and deliver the sample to your requested facility.
What if I live outside of the US?
We currently provide service to the United States, Canada, the Caribbean, Central and South America. If you live in another area please send us a message to [email protected] and we'll let you know when we can service your location.
Copyright 2018, OOTHY LLC